Schistosoma mansoni: effects of anesthetics and antimonial drugs on worm shift in the mouse

Cunha-Melo, José Renan; Coelho, Paulo Marcos Zech

doi:10.1590/s0036-46651986000400010

Cited by 5 publications

(2 citation statements)

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“…Alternatively, it implies that schistosomes migrated to the brain or spinal cord after treatment was started. It is possible that the anesthetic used in the surgical procedure (brain biopsy) may have dislodged the worms from their usual habitat 7 . Another hypothesis is that cerebral vasculitis may appear after treating schistosomiasis with praziquantel, as has been reported by Jauréguiberry et al 8 in a patient with acute neuroschistosomiasis.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous occurrence of brain tumor and myeloradiculopathy in schistosomiasis mansoni: case report

Lambertucci

Souza-Pereira

Carvalho

2009

Rev. Soc. Bras. Med. Trop.

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Simultaneous occurrence of brain tumor and myeloradiculopathy in cases of Manson's schistosomiasis have only rarely been described. We report the case of a 38-year-old man who developed seizures during a trip to Puerto Rico and in whom a brain tumor was diagnosed by magnetic resonance imaging: brain biopsy revealed the diagnosis of schistosomiasis. He was transferred to a hospital in the United States and, during hospitalization, he developed sudden paraplegia. The diagnosis of myeloradiculopathy was confirmed at that time. He was administered praziquantel and steroids. The brain tumor disappeared, but the patient was left with paraplegia and fecal and urinary dysfunction. He has now been followed up in Brazil for one year, and his clinical state, imaging examinations and laboratory tests are presented here. Key-words:Brain tumor. Neuroschistosomiasis. Myeloradiculopathy. RESUMOTem sido descrita, raramente, na esquistossomose mansônica, a ocorrência simultânea de tumor cerebral e mielorradiculopatia. Relatamos aqui o caso de um homem de 38 anos que desenvolveu convulsões, durante viagem a Porto Rico, e um tumor cerebral foi diagnosticado à ressonância magnética: a biópsia do cérebro revelou o diagnóstico de esquistossomose. Ele foi transferido para hospital na América do Norte e durante a hospitalização desenvolveu súbita paraplegia. O diagnóstico de mielorradiculopatia foi confirmado na ocasião. Ele recebeu praziquantel e esteróides. O tumor cerebral desapareceu, mas o paciente permaneceu com paraplegia, disfunção urinária e fecal. Ele tem sido acompanhado no Brasil no último ano e o seu estado clínico, os métodos de imagem e os exames de laboratório são apresentados aqui. Palavras-chaves:Tumor cerebral. Neuroesquistossomose. Mielorradiculopatia. Neurological involvement is associated with infection by the three main species of Schistosoma (Schistosoma mansoni, Schistosoma japonicum and Schistosoma haematobium) 1 2 9 11 13 21 . Although myeloradiculopathy is the most common neurological complication of Schistosoma mansoni infection, the prevalence of cerebral and spinal cord schistosomiasis is unknown. Neuroschistosomiasis is probably underdiagnosed, underestimated and underreported 8 12 14 .Severe neurological involvement has been described during the early post-infective stage in non-immune patients 10 15 . Acute encephalitis and cerebral vasculitis have been reported during primary infection with Schistosoma mansoni 9 28 . Asymptomatic neuroschistosomiasis appears to be more frequent in association with the more severe chronic forms of Schistosoma mansoni. A Brazilian autopsy case series revealed scattered ova of Schistosoma mansoni in 25% of the brains of patients (without neurological deficit) who died due to hepatosplenic schistosomiasis 24 .Schistosoma mansoni can also cause a brain tumor-like syndrome due to slowly expanding cerebral and cerebellar lesions 4 6 15 18 23 24 26 27 .Schistosomal myeloradiculopathy is the most severe and disabling ectopic form of Schistosoma mansoni infection 11 13 1...

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Section: Discussionmentioning

confidence: 99%

Simultaneous occurrence of brain tumor and myeloradiculopathy in schistosomiasis mansoni: case report

Lambertucci

Souza-Pereira

Carvalho

2009

Rev. Soc. Bras. Med. Trop.

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“…The worm migrates from mesenteric veins to the liver (Woolhouse & Kaye 1977). This same fact can be oberved when these mice are submitted to anesthaestic drugs, as ether and chlorophorm (Khayyal 1965), nembutal (Goldsmith & Kean 1966), fluotane (Motta et al 1968), halotane (Cunha-Melo & Coelho 1986), pentobarbital and sodium phenobarbital (Machado e Silva et al 1993, 1996. However, it is not established if this migration is due to the action of the drug in the host and/or directly in the adult worms.…”

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confidence: 89%