Acute pulmonary histoplasmosis and first isolation of Histoplasma capsulatum from soil of Rio Grande do Sul, Brazil

Severo, Luiz Carlos; Petrillo, V.F.; Camargo, J. J.; Geyer, G; Porto, N. S.

doi:10.1590/s0036-46651986000100009

Cited by 13 publications

(14 citation statements)

References 6 publications

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“…Clinical presentation in the oropharyngeal area includes ulceration, nodular-ulcerative lesions, granulomas, verrucous and plaque-like lesions. Even following the outbreak of AIDS, reports of oral involvement by histoplasmosis have been rare in America and Europe 2,[10][11][12] .…”

Section: Discussionmentioning

confidence: 99%

“…In conclusion, oral histoplasmosis is closely associated with immunosuppression status, especially in patients presenting AIDS 1,2,6,[10][11][12][13] . In some cases, it is the initial indication of AIDS, as reported in literature 11,12 .…”

Section: Discussionmentioning

confidence: 99%

“…Histoplasmosis is a worldwide systemic mycosis caused by Histoplasma capsulatum, a dimorphic fungus that has been isolated from soil contaminated with bird or bat droppings in endemic areas, as reported in Brazil and central United States [1][2][3][4] . Infection occurs almost exclusively by inhalation of airborne conidia or mycelial fragments [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

“…Infection occurs almost exclusively by inhalation of airborne conidia or mycelial fragments [1][2][3][4] . The course of histoplasmosis can be influenced by the immune status of the host and by the quantity of infective propagules the host is exposed to 1,5,6 .…”

Section: Introductionmentioning

confidence: 99%

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Oropharyngeal histoplasmosis: report of eleven cases and review of the literature

Antonello

Zaltron

Vial

et al. 2011

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: Histoplasmosis is a systemic mycosis endemic in Brazil, especially in the State of Rio Grande do Sul, where Histoplasma capsulatum was isolated from the soil. H. capsulatum may compromise unusual areas, including the oropharynx, particularly in patients presenting disseminated histoplasmosis; which is associated with a state of immunosuppression, such as AIDS. METHODS: During database analysis of a total of 265 cases of histoplasmosis, the medical records of 11 patients with histological or microbiological diagnoses of oral histoplasmosis (OH) between 1987 and 2008 were retrospectively reviewed. RESULTS: This work reports 11 cases of OH, the majority presenting histopathological or microbiological evidence of disseminated histoplasmosis (DH). In the patients with DH, OH was the first manifestation of histoplasmosis. Five of the 11 patients discussed were HIV-seropositive with clinical and laboratory findings of AIDS. Four patients presented active pulmonary tuberculosis concomitant with histoplasmosis. Treatment was based on the use of itraconazole and amphotericin B deoxycholate. Eight patients responded successfully to therapy after one year, two did not come back for reevaluation and one died despite adequate therapy. CONCLUSIONS: Oral histoplasmosis is closely associated with immunosuppression status, especially in patients presenting AIDS; moreover, in many cases, OH is the first sign of disseminated histoplasmosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Oropharyngeal histoplasmosis: report of eleven cases and review of the literature

Antonello

Zaltron

Vial

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…Os histoplasmomas costumam ser solitários 2 . Quando múltiplos (casos 6,7,12,14), apresentam um granuloma dominante e, assim como os paracoccidiodomas múltiplos, simulam granulomatose de Wegener 16 18 . O diagnóstico é realizado quando da ressecção cirúrgica através de exame histopatológico da peça com a coloração de H&E 10 15 17 .…”

Section: Discussionunclassified

Histoplasmoma pulmonar no Rio Grande do Sul

Unis

Pêgas

Severo

2005

Rev. Soc. Bras. Med. Trop.

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Foram revisados dezesseis prontuários de pacientes que apresentavam nódulo pulmonar à radiografia de tórax diagnosticados como histoplasmoma através de achado histopatológico demonstrando elementos fúngicos compatíveis com Histoplasma capsulatum var capsulatum no Rio Grande do Sul. Revisada a literatura brasileira. Todos os pacientes eram brancos, nove eram homens, a média de idade foi de 50,8 anos. Seis (37,5%) pacientes tinham história epidemiológica sugestiva de contato com fungo. Os nódulos variaram de 0,7 a 2,7 cm de diâmetro, apresentavam-se como granuloma com necrose caseosa. Doze (75%) pacientes apresentavam nódulo solitário. O histoplasmoma como regra se apresenta como nódulo solitário com até três centímetros de diâmetro em paciente assintomático. O diagnóstico é realizado por exame histopatológico com coloração especial para visualização do fungo, método de Gomori-Grocott com metenamina argêntica. Cultivo ou testes soromicológicos não contribuem para o diagnóstico.

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Epidemiological study of sporotrichosis and histoplasmosis in captive Latin American wild mammals, S�o Paulo, Brazil

Costa¹,

Diniz²,

Netto

et al. 1994

Mycopathologia

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Sporotrichosis and histoplasmosis are deep mycosis with a high incidence in human beings in Brazil. In domestic animals histoplasmosis has been described only in dogs, but the occurrence of sporotrichosis among domestic animals in Brazil has been described in dogs, cats, mules and asses. There is also a case of this disease reported in a chimpanzee (Pan troglodites). The purpose of this research was to perform an epidomiological study of these mycoses using delayed hypersensitivity tests (histoplasmin and sporotrichin) in Latin American wild mammals. This research was assayed using 96 healthy animals at Parque Zoológico de São Paulo, Brazil: Primates: 33 Cebus apella--weeping-capuchin and 16 Callithrix jacchus--marmoset; Procyonidae: 37 Nasua nasua--coatimundi and 10 Felidae (Panthera onca--jaguar; Felis pardalis--ocelot Felis wiedii--margay; Felis tigrina--wild cat). For intradermic tests, the following antigens were used: Sporothrix schenkii cell suspension (sporotrichin, histoplasmin-filtrate), Histoplasma capsulatum cell suspension (histoplasmin), and Histoplasma capsulatum (polysaccharide). The positivity to histoplasmin was 44.79% (Cebidae 15.15%; Callithricidae 6.25%; Procyonidae 86.49% and Felidae 50.00%, respectively). With respect to sporotrichin, 30.21% (Cebidae 6.06%, Callithricidae 0.0%; Procyonidae 64.86% and Felidae 30.00% respectively). The pattern of infection is similar to that shown by human beings and this may suggest that these animals could be involved in the epidemiologic chain of sporotrichosis and histoplasmosis, the second most prevalent human deep mycoses in Brazil. It is important to point out the absence of similar studies in Latin American wild animals.

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Acute pulmonary histoplasmosis and first isolation of Histoplasma capsulatum from soil of Rio Grande do Sul, Brazil

Cited by 13 publications

References 6 publications

Oropharyngeal histoplasmosis: report of eleven cases and review of the literature

Oropharyngeal histoplasmosis: report of eleven cases and review of the literature

Histoplasmoma pulmonar no Rio Grande do Sul

Epidemiological study of sporotrichosis and histoplasmosis in captive Latin American wild mammals, S�o Paulo, Brazil

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