Leishmaniose cutânea na Amazônia: registro do primeiro caso humano de infecção mista, determinado por duas espécies distintas de Leishmnias: Leishmania brasiliensis e Leishmania mexicana amazonensis

Sílveira, Fernando Tobias; Lainson, Ralph; Shaw, Jeffrey Jon; Ribeiro, Renata da Silva

doi:10.1590/s0036-46651984000500008

Cited by 23 publications

(8 citation statements)

References 7 publications

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“…braziliensis and L . amazonensis [59], we believe that the occurrence and frequency of natural infection by different species of Leishmania are more common than the literature would suggest, particularly in foci where the two species overlap.…”

Section: Discussionmentioning

confidence: 99%

Leishmania infection and blood food sources of phlebotomines in an area of Brazil endemic for visceral and tegumentary leishmaniasis

Guimarães-E-Silva

Silva

et al. 2017

PLoS ONE

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The aims of the study were to determine the blood feeding preferences of sandflies and to identify species of Leishmania that infected phlebotomines in Caxias, Maranhão, Brazil, an area that is highly endemic for leishmaniasis. Sandflies were captured in light traps located in the peridomiciliary environments of randomly selected houses in urban and rural settings between 1800 and 0600 hours on new moon days between March 2013 and February 2015. DNA extracts from 982 engorged female sandflies were submitted to fragment length polymorphism analysis to identify infecting species of Leishmania, and blood sources were identified for 778 of these specimens. Infection by Leishmania infantum was detected in Lutzomyia longipalpis, Lu. whitmani and Lu. termitophila; L. infantum/L. braziliensis in Lu. longipalpis, Lu. whitmani and Lu. trinidadensis; L. shawi in Lu. longipalpis; L. mexicana in Lu. longipalpis; L. braziliensis in Lu. longipalpis and Lu. whitmani; L. guyanensis in Lu. longipalpis and Lu. termitophila; L. amazonensis in Lu. longipalpis and L. lainsoni or L. naiffi in Lu. longipalpis, while Lu. longipalpis and Lu. trinidadensis were infected with unidentified Leishmania sp. Blood sources were identified in 573 individual phlebotomines and the preferred hosts were, in decreasing order, chicken, dog, rodent and human with lower preferences for pig, horse, opossum and cattle. Lu. longipalpis and Lu. whitmani performed mixed feeding on man, dog and rodent, while Lu. longipalpis was the most opportunistic species, feeding on the blood of all hosts surveyed, but preferably on dog/chicken, dog/rodent and rodent/chicken. Our findings reveal the concomitant circulation of Leishmania species that cause visceral leishmaniasis and tegumentary leishmaniasis in the study area, and explain the occurrence of autochthonous human cases of both clinical forms of leishmaniasis in Caxias, Maranhão. The results support our hypothesis that, in the municipality of Caxias, transmission of Leishmania occurs in close proximity to humans.

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Section: Discussionmentioning

confidence: 99%

Leishmania infection and blood food sources of phlebotomines in an area of Brazil endemic for visceral and tegumentary leishmaniasis

Guimarães-E-Silva

Silva

et al. 2017

PLoS ONE

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“…Thus, early diagnosis followed by effective therapy may link a parasite genotype commonly found in mucosal leishmaniasis and disseminated leishmaniasis to cutaneous leishmaniasis. Another important cautionary note regards the possibility of mixed infections previously reported in New and Old World leishmaniases (15,21,28,29). In such instances, a dominant strain, possibly due to its greater relative load, immune response evasiveness, or drug resistance, may more strongly influence outcome.…”

Section: Vol 72 2004 Genetic Polymorphism Of L Braziliensis 511mentioning

confidence: 97%

MulticlonalLeishmania braziliensisPopulation Structure and Its Clinical Implication in a Region of Endemicity for American Tegumentary Leishmaniasis

et al. 2004

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In Corte de Pedra (CP), northeastern Brazil, Leishmania braziliensis causes three distinct forms of American tegumentary leishmaniasis (ATL). To test the hypothesis that strain polymorphism may be involved in this disease spectrum and accurately characterize the parasite population structure in CP, we compared one L. major, two non-CP L. braziliensis, one CP L. amazonensis, and 45 CP L. braziliensis isolates, obtained over a 10-year period from localized cutaneous, mucosal, and disseminated leishmaniasis patients, with randomly amplified polymorphic DNA (RAPD). Electrophoretic profiles were mostly unique across species. All typing protocols revealed polymorphism among the 45 CP L. braziliensis isolates, which displayed eight different RAPD patterns and greater than 80% overall fingerprint identity, attesting to the adequacy of the tools to assess strain variability in CP's geographically limited population of parasites. The dendrogram based on the sum of RAPD profiles of each isolate unveiled nine discrete typing units clustered into five clades. Global positioning showed extensive overlap of these clades in CP, precluding geographic sequestration as the mechanism of the observed structuralization. Finally, all forms of ATL presented a statistically significant difference in their frequencies among the clades, suggesting that L. braziliensis genotypes may be accompanied by specific disease manifestation after infection.

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“…ML, the hyperergic invasive ulcerative form that progresses in the absence of any apparent cellular defect, is most frequently associated with L. braziliensis (103), but Leishmania panamensis (278), Leishmania guyanensis (213,277), and members of the L. mexicana complex (26,313) can also cause this mutilating form of the disease. In addition, a few human cases of mixed parasite infections (L. braziliensis and L. amazonensis or L. braziliensis and L. chagasi) have been described (221,289). Cases of CL apparently due to naturally occurring hybrid parasites (L. braziliensis x L. panamensis and L. braziliensis x L. guyanensis) have also been reported recently from Nicaragua (71) and Venezuela (41), respectively.…”

Section: The Human Leishmaniases Clinical Forms and Etiologymentioning

confidence: 99%

Leishmaniases of the New World: current concepts and implications for future research

1993

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Recent epidemiologic studies indicate that leishmaniasis in the Americas is far more abundant and of greater public health importance than was previously recognized. The disease in the New World is caused by a number of different parasite species that are capable of producing a wide variety of clinical manifestations. The outcome of leishmanial infection in humans is largely dependent on the immune responsiveness of the host and the virulence of the infecting parasite strain. This article reviews current concepts of the clinical forms, immunology, pathology, laboratory diagnosis, and treatment of the disease as well as aspects of its epidemiology and control. Recommendations for future research on the disease and its control are made.

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Leishmaniose cutânea na Amazônia: registro do primeiro caso humano de infecção mista, determinado por duas espécies distintas de Leishmnias: Leishmania brasiliensis e Leishmania mexicana amazonensis

Cited by 23 publications

References 7 publications

Leishmania infection and blood food sources of phlebotomines in an area of Brazil endemic for visceral and tegumentary leishmaniasis

Leishmania infection and blood food sources of phlebotomines in an area of Brazil endemic for visceral and tegumentary leishmaniasis

MulticlonalLeishmania braziliensisPopulation Structure and Its Clinical Implication in a Region of Endemicity for American Tegumentary Leishmaniasis

Leishmaniases of the New World: current concepts and implications for future research

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