Inquérito com paracoccidioidina em uma população da Bahia (Brasil)

Andrade, José Célio Silveira; Andrade, Tarcísio Matos de; Lacaz, Carlos da Silva; Rodrigues, Maria Conceição; Preuß, M.; Lorenço, Rosemarie; Badaro, Roberto

doi:10.1590/s0036-46651984000100001

Cited by 11 publications

(8 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Epidemiological surveys with a paracoccidioidin intradermal test show a high prevalence of reactors individuals, including in humans, sheep, cows, and horses. 3,4,[31][32][33] These data suggest that the prevalence rate of P. brasiliensis human infection in endemic areas may be as high as 50 to 75% in the adult population. [4][5][6][7] Estimates of the incidence of PCM vary from one to three new cases per 100,000 inhabitants of endemic areas with an estimated mortality rate of 1.45 deaths per million inhabitants, according to data from the Brazilian Ministry of Health.…”

mentioning

confidence: 85%

Pulmonary Paracoccidioidomycosis

Queiroz‐Telles

Escuissato

2011

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Paracoccidioidomycosis is a subacute or chronic systemic mycosis caused by Paracoccidioides brasiliensis, a soil saprophyte and thermally dimorphic fungus. The disease occurs mainly in rural workers in Latin America and is the most frequent endemic systemic mycosis in many countries of South America, where almost 10 million people are believed to be infected. Paracoccidioidomycosis should be regarded as a disease of travelers outside the endemic area. The primary pulmonary infection is subclinical in most cases, and individuals may remain infected throughout life without ever developing clinical signs. A small proportion of patients present with clinical disease. The lungs are frequently involved, and the pulmonary clinical manifestations must be differentiated from many other infectious and noninfectious conditions. Diagnosis should be based on epidemiological, clinical, and microbiological data. Effective treatment regimens are available to control the fungal infection, but most patients develop fibrotic sequelae that may severely hamper respiratory and adrenal function and the patient's well-being.

show abstract

mentioning

confidence: 85%

Pulmonary Paracoccidioidomycosis

Queiroz‐Telles

Escuissato

2011

Semin Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…The first recorded attempt to demonstrate DTH in patients with paracoccidioidomycosis was that of Fonseca and Area-Leao, who intradermally injected a mycelial filtrate into two patients, both of whom proved reactive (109). Since then, numerous investigators have employed exocellular and intracellular P. brasiliensis antigens to study skin reactivity in both infected patients and healthy populations (14,75,85,92,136,179,180,210,267,296). In 1961, Fava-Netto and Raphael (101) reported the use of the polysaccharide antigen (intracellular and cytoplasmic) for skin testing.…”

Section: Microbiologymentioning

confidence: 99%

Paracoccidioidomycosis: an update

1993

View full text Add to dashboard Cite

This review summarizes knowledge on various aspects of paracoccidioidomycosis. Mycelial propagules, chlamydospores, and arthroconidia exhibit thermal dimorphism; arthroconidia are infectious in animals and, by electron microscopy, appear well provided for survival. The mycelial-to-yeast-phase transformation requires a strict control of glucan synthesis probably mediated by membrane enzymes. Hormonal influences on the transformation of the fungus (mycelium or conidium to yeast phase) have been demonstrated. Estrogen-binding proteins have been detected in the fungal cytosol, and during the transformation novel proteins are produced as a result of estradiol incorporation. Clinical forms have been better defined on the basis of better experimental models. Emphasis has been placed on the lungs as the portal of entry and on the existence of silent pulmonary infections. A specific Paracoccidioides brasiliensis antigen, the 43-kDa glycoprotein (Gp43), has been identified, characterized, and cloned. This has led to improved reproducibility and specificity of serologic tests. The depression of cell-mediated immune responses has been associated with severe disease in humans and in the experimental host. T-cell subsets in patients' tissues were characterized by means of monoclonal antibodies, and a reduced CD4/CD8 ratio was demonstrated. This has been related to alterations in lymphokine and tumor necrosis factor production, production of antigen-antibody complexes, etc. Amphotericin B has provided effective therapy. Azole derivatives have also improved prognosis and facilitated therapy. Itraconazole is presently the drug of choice, yet incapacitating sequelae (mainly pulmonary fibrosis) still constitute major problems.

show abstract

“…Since then, numerous investigators have employed exocellular and intracellular P. brasiliensis antigens to study skin reactivity in both infected patients and healthy populations (14,75,85,92,136,179,180,210,267,296).…”

Section: Immunodiagnosismentioning

confidence: 99%