Centenário da doença de Chagas

Neto, Vicente Amato; Pasternak, Jacyr

doi:10.1590/s0034-89102009000200022

Cited by 11 publications

(6 citation statements)

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“…In Brazil, the infection has already afflicted about 2.5 million individuals [4] despite the success of control measures responsible of elimination of domestic and peridomestic colonies of vector and monitoring of blood banks, which reduced incidence by approximately 70% in the Southern Cone countries. Due to the intense population migration and mobility, Chagas disease has spread in North America and Europe and is now global [5, 6].…”

Section: Chagas Diseasementioning

confidence: 99%

Biologic and Genetics Aspects of Chagas Disease at Endemic Areas

Bellini

Silistino-Souza

Varella‐Garcia

et al. 2012

Journal of Tropical Medicine

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The etiologic agent of Chagas Disease is theTrypanosoma cruzi, transmitted through blood-sucking insect vectors of the Triatominae subfamily, representing one of the most serious public health concerns in Latin America. There are geographic variations in the prevalence of clinical forms and morbidity of Chagas disease, likely due to genetic variation of theT. cruziand the host genetic and environmental features. Increasing evidence has supported that inflammatory cytokines and chemokines are responsible for the generation of the inflammatory infiltrate and tissue damage. Moreover, genetic polymorphisms, protein expression levels, and genomic imbalances are associated with disease progression. This paper discusses these key aspects. Large surveys were carried out in Brazil and served as baseline for definition of the control measures adopted. However, Chagas disease is still active, and aspects such as host-parasite interactions, genetic mechanisms of cellular interaction, genetic variability, and tropism need further investigations in the attempt to eradicate the disease.

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Section: Chagas Diseasementioning

confidence: 99%

Biologic and Genetics Aspects of Chagas Disease at Endemic Areas

Bellini

Silistino-Souza

Varella‐Garcia

et al. 2012

Journal of Tropical Medicine

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“…A Doença de Chagas (DC) é reconhecida pela Organização Mundial da Saúde (OMS) como uma das 17 doenças tropicais mais negligenciadas do mundo 1 . Causada pelo parasita Trypanosoma cruzi 2 , a DC constitui um importante problema de saúde pública, sobretudo na América Latina, onde se estima que existam seis milhões de indivíduos infectados e 28 milhões sob o risco de contrair a infecção, com mais de 10 mil óbitos anuais 1 . No Brasil, há cerca de 2.500.000 indivíduos infectados pelo T. cruzi [1][2][3] .…”

Section: ▄ Introduçãounclassified

“…Causada pelo parasita Trypanosoma cruzi 2 , a DC constitui um importante problema de saúde pública, sobretudo na América Latina, onde se estima que existam seis milhões de indivíduos infectados e 28 milhões sob o risco de contrair a infecção, com mais de 10 mil óbitos anuais 1 . No Brasil, há cerca de 2.500.000 indivíduos infectados pelo T. cruzi [1][2][3] . Apesar disso, as opções terapêuticas continuam limitadas e atualmente no mundo inteiro, dispõe-se apenas de dois fármacos para combater especificamente o parasita da DC: Benzonidazol (BZN) e Nifurtimox 2,4 .…”

Section: ▄ Introduçãounclassified

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Reações adversas ao benzonidazol no tratamento da Doença de Chagas: revisão sistemática de ensaios clínicos randomizados e controlados

et al. 2019

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Resumo Introdução No Brasil, a única droga disponível para o tratamento específico do Trypanosoma cruzi, causador da Doença de Chagas (DC) é o Benzonidazol (BZN), cujas reações adversas podem propiciar a interrupção do tratamento. Objetivo O objetivo desse trabalho é quantificar a proporção de ocorrência de efeitos adversos, descrevê-los e identificar os fatores de risco associados à essa ocorrência. Método Revisão sistemática conduzida de acordo com os padrões estabelecidos pelo Preferred Reporting Items is Systematic Reviews and Metanalyses (PRISMA). Incluíram-se somente ensaios clínicos randomizados controlados. Resultados Dos 134 estudos identificados, cinco foram incluídos. O tamanho da amostra variou de 77 a 2854 pessoas, e a faixa etária dos participantes, variou de zero a 75 anos. Todos os estudos incluídos apontaram reações adversas ao uso do BZN. A frequência de reação adversa chegou a 38% e a mais comum foi o rash cutâneo. O abandono do tratamento devido à reação foi citado em três estudos, variando de 6,4% a 13,4%. Conclusão As reações adversas ao uso do BZN variaram de acordo com a idade do paciente e esquema terapêutico de dose e tempo adotado, sendo o conhecimento médico acerca dessas reações imprescindível para seu uso seguro e adesão ao tratamento.

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“…Of these articles, we have classic texts by Forattini on the biology of Triatominae 63 - 68 . Studies on the burden of Chagas disease in different regions of the Country 40 , 155 , 176 , control strategies 139 - 141 , and alternative transmission types of Chagas disease 175 are also present, as well as the disease social impact and, more recently, an interesting article on the 100th anniversary of the Chagas disease description 6 .…”

Section: Introductionmentioning

confidence: 99%

Path of infectious diseases in Brazil in the last 50 years: an ongoing challenge

Waldman

Sato

2016

Rev. Saúde Pública

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In this article, we comment on the main features of infectious diseases in Brazil in the last 50 years, highlighting how much of this path Revista de Saúde Pública could portray. From 1967 to 2016, 1,335 articles focusing on infectious diseases were published in Revista de Saúde Pública. Although the proportion of articles on the topic have decreased from about 50.0% to 15.0%, its notability remained and reflected the growing complexity of the research required for its control. It is noteworthy that studies design and analysis strategies progressively became more sophisticated, following the great development of epidemiology in Brazil in the recent decades. Thus, the journal has followed the success of public health interventions that permitted to control or eliminate numerous infectious diseases – which were responsible, in the past, for high rates of morbidity and mortality –, and also followed the reemergence of diseases already controlled and the emergence of until then unknown diseases, with a strong impact on the Brazilian population, establishing a little predictable and very challenging path.

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Centenário da doença de Chagas

Cited by 11 publications

References 0 publications

Biologic and Genetics Aspects of Chagas Disease at Endemic Areas

Biologic and Genetics Aspects of Chagas Disease at Endemic Areas

Reações adversas ao benzonidazol no tratamento da Doença de Chagas: revisão sistemática de ensaios clínicos randomizados e controlados

Path of infectious diseases in Brazil in the last 50 years: an ongoing challenge

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