Ensaios preliminares em laboratório para verificar a ação moluscicida de algumas espécies da flora brasileira

Mendes, Nelymar Martineli; Pereira, José Paulo; Souza, Cecília Pereira de; Oliveira, Maria de Lourdes Lima de

doi:10.1590/s0034-89101984000500003

Cited by 22 publications

(14 citation statements)

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(1 reference statement)

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“…In the assays with P. angulata, pH adjustment of the tested solutions was avoided, because, according to Fox et al (1963) and Pereira and Souza (1974), any pH alteration in the solutions to be tested, is capable of influencing the result. Regarding the used parts of the plant, several authors worked with raw extracts (Mendes et al 1984) and fractions (Pereira et al 1978), a methodology which we followed and with which we obtained positive results also confirming the differences among parts used. Thus ethanolic extracts from the leaves and roots of P. angulata are molluscicidal, ethanolic extracts from the stem and the whole plant are inactive.…”

Section: Discussionsupporting

confidence: 69%

“…The present results, using the described methodology allow the determination of LD 50 and LD 90 in the solutions. Rouquayrol et al (1973), working with leaves, fruit, stem, root, and seeds of Pithecelobium multiflorum Bent (canafistula), using the crude aqueous and ethanolic raw extracts, measured the molluscicidal activity; these results were also observed with hexane extracts, as indicated by Mendes et al (1984). However, we did not use the methodology of Rouquayrol et al (1980), in which the solution in distilled water was neutralized by the addition of dilute aqueous hydrochloric acid or aqueous sodium hydroxide, although the authors registered positive results.…”

Section: Discussionmentioning

confidence: 95%

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Molluscicidal activity of Physalis angulata L. extracts and fractions on Biomphalaria tenagophila (d'Orbigny, 1835) under laboratory conditions

Santos

Tomassini

Xavier

et al. 2003

Mem. Inst. Oswaldo Cruz

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 95%

Molluscicidal activity of Physalis angulata L. extracts and fractions on Biomphalaria tenagophila (d'Orbigny, 1835) under laboratory conditions

Santos

Tomassini

Xavier

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…Jurberg et al (1989) (Mendes et al 1984). Of these, E. splendens stands out for its molluscidal activity in doses under 0.5 mg/l, eight times smaller than the lethal dose for fish (Vasconcellos & Schall 1986).…”

Section: Abstract: Plant Molluscide -Euphorbia Splendens Var Hislopmentioning

confidence: 99%

“…Jurberg et al (1989) studied over 340 species, pointing out the Euphorbiaceae and Sapindaceae families as having the greatest number of species with effective molluscidal potential. The following species have been studied: Anacardium occidendale (Pereira & Souza 1974), Euphorbia pulcherrima, Euphorbia splendens, Caesalpinia peltophoroides, and Stryphnodendron adstringens (Mendes et al 1984). Of these, E. splendens stands out for its molluscidal activity in doses under 0.5 mg/l, eight times smaller than the lethal dose for fish (Vasconcellos & Schall 1986).…”

Section: Physiological Changes In Biomphalaria Glabratamentioning

confidence: 99%

Physiological changes in Biomphalaria glabrata say, 1818 (Pulmonata: Planorbidae) caused by sub-lethal concentrations of the latex of Euphorbia splendens var. hislopii N.E.B (Euphorbiaceae)

Mello-Silva

Vasconcellos

Pinheiro

et al. 2006

Mem. Inst. Oswaldo Cruz

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Molluscides have been used as one of the strategies to control schistosomiasis. Many plant extracts with molluscidal effects have been tested, but the action of the latex of Euphorbia splendens var. hislopii is considered the most promising because it meets the recommendations of the World Health Organization (WHO). The objective of this study was to determine the lethal dose and identify the effects of the different doses of latex of E. splendens var.hislopii on the physiology of Biomphalaria glabrata submitted to treatment for 24 h. The concentrations of glucose, uric acid and total proteins in the hemolymph and of glycogen in the digestive gland and cephalopodal mass were determined. The LD 50 value was 1 mg/l. The highest escape index was found to be at a concentration of 0.6 mg/l. The results showed that the latex of E. splendens var. hislopii caused a sharp reduction in the reserves of glycogen in the digestive gland and elevation of the protein content in the hemolymph of B. glabrata. Key words: plant molluscide -Euphorbia splendens var. hislopii -Biomphalaria glabrataThe use of molluscides as one of the strategies to control schistosomiasis began in Brazil in 1976, with the creation of the Special Schistosomiasis Control Program by the National Health Foundation (Machado 1982). The product used in the program was niclosamide, an ethanolamine salt of 2',5-dichloro-4'-nitrosalicylanilide, manufactured under the trade name Bayluscide  , whose efficacy had previously been established (Gonnert 1961). Application of this product caused biocidal action on non-target plants and animals (Andrews et al. 1983), besides causing genotoxicity and carcinogenic effects (Vega et al. 1988). The high cost (Pieri 1995), the possibility of recolonization of breeding grounds (Sarquis et al. 1997(Sarquis et al. , 1998, and the ecological toxicity of this product were limitations on its use as an official molluscide in government programs to control schistosomiasis.At the same time, various plants were tested as natural molluscides. Jurberg et al. (1989) (Mendes et al. 1984). Of these, E. splendens stands out for its molluscidal activity in doses under 0.5 mg/l, eight times smaller than the lethal dose for fish (Vasconcellos & Schall 1986).Some questions have arisen in the selection of plant molluscides, such as: toxicity, availability, annual growth, adaptability to different local conditions, and location of molluscidal activity in parts of the plant that easily regenerate, such as the leaves. To be eligible for use, a product must be storable and remain viable for at least one year; be physically and chemically stable; have ethnobotanical value; and be easy to extract and apply, preferably in aqueous extracts (Kloos & McCullough 1982). Considering all these criteria, in 1998 the Oswaldo Cruz Institute (IOC, Fiocruz, RJ) obtained a biotechnology patent on a method to collect, extract and apply E. splendens var. hislopii latex as a molluscide (Vasconcellos 2000).In the published works on plants with molluscidal action and ...

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“…No sentido de adquirir produtos com alto teor moluscicida a partir de extratos vegetais, muitos autores se dedicaram à pesquisa com plantas regionais, sendo que muitas espécies ornamentais, tóxicas e medicinais foram avaliadas quanto à possível ação moluscicida (Mendes et , 1984;Leyton et al, 2005, Babili et al, 2006.…”

Section: Atividade Moluscicida De Plantasunclassified

Atividade moluscicida de plantas: uma alternativa profilática

Cantanhêde¹,

Marques²,

Silva-Souza³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: Uma das formas de combate a helmintos que possuem moluscos em seu ciclo biológico é o controle da população malacológica. A tentativa de combater os criadouros naturais de hospedeiros intermediários, através de moluscicidas, tem sido uma das formas almejadas para a redução da incidência de enfermidades, como as esquistossomoses e fascioloses. Essa medida epidemiológica tem se concretizado através da utilização dos moluscicidas sintéticos que, dentre outras desvantagens, trazem danos ao ecossistema. Visando a obtenção de novos compostos, os estudos sobre a potencialidade de produtos naturais moluscicidas têm crescido consideravelmente. Alguns pesquisadores apontam os moluscicidas vegetais como fontes alternativas para o tratamento profilático de parasitoses. Tendo em vista a abrangência, endemicidade e relevância, este trabalho revela um maior enfoque à atividade moluscicida de plantas relacionada às esquistossomíases. Unitermos: moluscicida, vegetal, esquistossomose.ABSTRACT: "Plant molluscicidal activity: a prophylactic alternative". An effective way to combat helminthes having mollusk in their life cycle is by controlling their population. The attempt to battle the natural breeding of intermediary hosts through molluscicides has been the targeted approach to reduce the incidence of such diseases as schistosomiasis and fascioloses. This epidemiological measure has been performed using synthetic molluscicides which, among other drawbacks, cause damages to the ecosystem. In order to obtain new compounds, studies on the potential of natural molluscicides products are increasing. Researchers draw attention to molluscicides plants as alternative sources for the prophylactic management of parasitoses. In view of the scope, significance and endemism, the present work highlights plant activities related to schistosomiasis.

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Ensaios preliminares em laboratório para verificar a ação moluscicida de algumas espécies da flora brasileira

Cited by 22 publications

References 1 publication

Molluscicidal activity of Physalis angulata L. extracts and fractions on Biomphalaria tenagophila (d'Orbigny, 1835) under laboratory conditions

Molluscicidal activity of Physalis angulata L. extracts and fractions on Biomphalaria tenagophila (d'Orbigny, 1835) under laboratory conditions

Physiological changes in Biomphalaria glabrata say, 1818 (Pulmonata: Planorbidae) caused by sub-lethal concentrations of the latex of Euphorbia splendens var. hislopii N.E.B (Euphorbiaceae)

Atividade moluscicida de plantas: uma alternativa profilática

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