Investigação epidemiológica de um caso de leishmaniose visceral autóctone da Grande São Paulo, Brasil

Iversson, Lygia Busch; Camargo, M. E.; Silva, Eduardo Olavo da Rocha e; Chieffi, Pedro Paulo; Barros, José Augusto Cabral de

doi:10.1590/s0034-89101979000200012

Cited by 20 publications

(14 citation statements)

References 4 publications

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“…Of these two from Greater São Paulo (Iversson et al 1979(Iversson et al , 1982 are particularly important because there was evidence of sub-clinical infections in children from the same neighbourhood as one of the sick children. Neither Lu.…”

Section: Transmission Ofmentioning

confidence: 99%

[No Title Available]

Shaw¹

2007

Mem. Inst. Oswaldo Cruz

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Section: Transmission Ofmentioning

confidence: 99%

[No Title Available]

Shaw¹

2007

Mem. Inst. Oswaldo Cruz

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“…10,b,c In the state of São Paulo, the first report of the human disease's autochthony was made in the metropolitan area of São Paulo, in 1978. 10 However, at that time, it was not possible to identify the reservoir and vector in the links of transmission chain. In 1998, in the city of Araçatuba, the presence of Leishmania sp.…”

mentioning

confidence: 99%

Análise TG-ROC de testes de imunofluorescência no diagnóstico de leishmaniose visceral canina

et al. 2009

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TG-ROC analysis of immunofluorescence assays in canine visceral leishmaniasis diagnosis ABSTRACT OBJECTIVE:To analyze the accuracy of the diagnosis of two protocols of indirect immunofluorescence assays for canine visceral leishmaniasis. METHODS:Dogs from the seroepidemiological survey conducted in an endemic area of the cities of Araçatuba and Andradina, in Northwestern São Paulo state, in 2003, and in a non-endemic area of the metropolitan region of São Paulo, were used to assess two protocols of indirect immunofluorescence assay (IFA) for leishmaniasis: one using a Leishmania major heterologous antigen (IFA-BM) and another using a Leishmania chagasi homologous antigen (IFA-CH). Two-graph receiver operating characteristic (TG-ROC) analysis was used to estimate accuracy. TG-ROC analysis compared 1:20 dilution readings of the homologous antigen (IFA-CH), considered as reference test, with IFA-BM dilutions (heterologous antigen). RESULTS:The 1:20 dilution used in the IFA-CH test showed the best contingency coefficient (0.755) and the highest strength of association between the two variables studied (chi-square=124.3). Thus, it was considered the test reference dilution in comparisons with different IFA-BM test dilutions. The best IFA-BM results were obtained from 1:40 dilutions with the best contingency coefficient (0.680) and highest strength of association (chi-square=80.8). With the change in the cut-off point, recommended for the IFA-BM 1:40 dilution in this analysis, the specificity parameter value rose from 57.5% to 97.7%, even though the 1:80 dilution showed the best sensitivity estimate (80.2%), with the new cut-off point.CONCLUSIONS: TG-ROC analysis can provide important information about diagnostic tests, in addition to offering suggestions on cut-off points that can improve test sensitivity and specificity estimates and assessing these tests in terms of the best cost-benefit ratio.

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“…The inland foci are encountered in the semi-arid zone whose areas with abundant vegetation are named boqueiroes presenting hot humid climate conditions. The disease has been slowed particularly in rural zone involving man, dog and Lutzomyia longipalpis, but sporadic foci from Rio de Janeiro, Sao Paulo, Teresina, Sao Luis and Marajo islands (Castro et al, 1983;Iversson et al, 1979;Amato-Neto and Bianco-Filho, 1981;Ryan and Brazil, 1984) change this epidemiological feature. Moreover, the disease occurs predominantly among children 0-10 years old.…”

Section: American Visceral Leishmaniasismentioning

confidence: 99%

American leishmaniasis epidemiology in Brazil

Gomes

1986

Int. J. Trop. Insect Sci.

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We have tried to demonstrate in this paper that visceral and cutaneous leishmaniasis are a great public health problem in Brazil. In relation to visceral leishmaniasis, the recognition of new foci denotes the increasing spread of endemic areas, but the areas of highest importance are located mainly at the northeastern region. It calls attention to its suburban character in cities like Sao Luis, Teresina and Rio de Janeiro. L. longipalpis is the only vector known for the disease in domiciliary environment. The dog constitutes the main source for L.d. chagasi, while canids such as Dusicyon velulus and Cerdocyon thous have epidemiological roles. Other vectors for this parasite remain yet as unknown in the enzootic and sylvatic cycles.Cutaneous leishmaniasis have a distribution in almost all the States of Brazil and, at least, two epidemiological patterns exist. The first, corresponds to the classic form of man entering in contact with the agent in virgin forests, like the Amazonian forest and so, there is a permanent risk for epidemics. The second, refers to the occurrence of this disease in areas after forest devastation as in the State of Sao Paulo and in other southeastern States. There are three nosological entities for the cutaneous leishmaniasis in Brazil, their agents being L.m. amazonensis, L. guyanensis and L.b. braziliensis. Five sandfly species have been incriminated as the main vectors in the transmission of the disease in different localities. They are P. flaviscutellatus, P. umbratilis, P. welcomei, P. whitmani and P. intermedius. As for the main natural reservoir of cutaneous leishmaniasis, it remains unknown the one relative to L.b. braziliensis.Resume-Au cours de nos travaux sur la leishmaniose viscerale et cutanee, il devient evident qu'elles representent un grand probleme de sante publique au Bresil nonobstant que se vraie prevalence soit encore ignoree.En ce qui concerne a la leishmaniose viscerale, la decouverte de nouveaux foyers denote l'acroissement de la distributions des surfaces endemiques. Cependant, les plus considerables se trouvent, surtout, a la region nord-est. On signe aussi le caractere suburbain de cette maladie aux villes de Sao Luiz, Teresina et Rio de Janeiro. La Lutzomyia longipalpis est l'unique vecteur connu de cette maladie avec un habitat domiciliaire. Le chien reste le principal reservoir de la Leishmania donovani chagasi mais d'autres especes de canin, tels que le Dusicyon vetulus et le Cerdocyon thous ont un role epidemiologique secondaire. Au cycle biologique sylvestre, les vecteurs restent encore inconnus.Les leishmanioses cutanees sont repandues par presque tous les etats bresilens et ainsi done, deux patrons epidemiologiques de la maladie ont ete classifies: le premier, fait rapport a la forme classique par laquelle Thome peut l'acquerir, e'est-a-dire, au contact avec l'agent, a l'Amazonie, ayant comme resultat um risque permanent d'epidemie. Le deuxiene fait egard a l'occurrence de la maladie aux regions de forets entierment devastees aux Etats de Sao Paulo et d'au...

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Investigação epidemiológica de um caso de leishmaniose visceral autóctone da Grande São Paulo, Brasil

Cited by 20 publications

References 4 publications

[No Title Available]

[No Title Available]

Análise TG-ROC de testes de imunofluorescência no diagnóstico de leishmaniose visceral canina

American leishmaniasis epidemiology in Brazil

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