Líquen plano bucal: considerações clínicas e histopatológicas

Sousa, Fernando Augusto Cervantes Garcia de; Rosa, Leonardo Cruz da

doi:10.1590/s0034-72992008000200021

Cited by 15 publications

(20 citation statements)

References 37 publications

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“…17 Its etiology remains unknown; however, it is believed that factors such as stress, the ingestion of acidic food and seasonings, systemic diseases including hepatitis C infection 9 and excessive alcohol intake and tobacco consumption are associated with periods of exacerbation of the disease. 10,18 In the present study, it was impossible to relate this dermatosis with any of the above-mentioned habits because of the absence of the relevant data on the charts consulted.…”

Section: Discussionmentioning

confidence: 76%

“…7 Cicatricial pemphigoid was referred to by Lo Russo et al as a group of chronic autoimmune bullous diseases in which autoantibodies are directed against one or more components of the basal membrane. 3,8,9,10 Bascones et al defined lichen planus as a chronic mucocutaneous disease of an inflammatory nature and undefined etiology in which lymphocytes attack the basal cells of the epithelium in the oral mucosa. 11 Scully and Carrozzo called attention to the fact that various clinical forms of lichen planus have been identified: reticular, papular, plaque-like, erosive (ulcerative) and bullous, and that these forms may occur separately or simultaneously.…”

Section: Introductionmentioning

confidence: 99%

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Estudo epidemiológico das doenças dermatológicas imunologicamente mediadas na cavidade oral

Carvalho

Santos

Vieira

et al. 2011

An. Bras. Dermatol.

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▲An epidemiological study of immune-mediated skin diseases affecting the oral cavity * Estudo epidemiológico das doenças dermatológicas imunologicamente mediadas na cavidade oral Abstract: BACKGROUND: Immune-mediated skin diseases encompass a variety of pathologies that present in different forms in the body. OBJECTIVE: The objective of this study was to establish the prevalence of the principal immune-mediated skin diseases affecting the oral cavity. METHODS: A total of 10,292 histopathology reports stored in the archives of the Anatomical Pathology Laboratory, Department of Oral Pathology, Federal University of Rio Grande do Norte, covering the period from 1988 to 2009, were evaluated. For the cases diagnosed with some type of disease relevant to the study, clinical data such as the gender, age and ethnicity of the patient, the anatomical site of the disease and its symptomatology were collected. RESULTS: Of all the cases registered at the above-mentioned service, 82 (0.8%) corresponded to immune-mediated skin diseases with symptoms affecting the oral cavity. The diseases found in this study were: oral lichen planus, pemphigus vulgaris and benign mucous membrane pemphigoid. Oral lichen planus was the most common lesion, comprising 68.05% of the cases analyzed. Of these cases, 64.3% were women and the cheek mucosa was the anatomical site most commonly affected (46.8%). CONCLUSION: Immune-mediated skin diseases affecting the oral cavity continue to be rare, the prevalence found in this study being similar to that reported for the majority of regions worldwide. Nevertheless, early diagnosis is indispensable in the treatment of these diseases, bearing in mind that systemic involvement is possible in these patients. Keywords: Lichen planus, oral; Pemphigoid, benign mucous membrane; Pemphigus

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Estudo epidemiológico das doenças dermatológicas imunologicamente mediadas na cavidade oral

Carvalho

Santos

Vieira

et al. 2011

An. Bras. Dermatol.

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“…In a signifi cant number of cases, the disease is associated with anxiety and depression, according to García-Pola Vallejo et al ( 2001 ). It occurs in patients of both sexes, with a predominance in women, generally over 40 years old (Souza and Rosa 2008 ).…”

Section: Oral Lichen Planus (Olp)mentioning

confidence: 99%

“…According to Souza and Rosa ( 2008 ), stress; food such as tomatoes, citrus fruits and spicy dishes; dental procedures; systemic diseases; abuse of alcohol and use of any source of tobacco are associated to periods of exacerbation of the disease. The concern of its association with systemic diseases, especially hepatitis C virus (HCV) infections, is rising in recent years.…”

Section: Oral Lichen Planus (Olp)mentioning

confidence: 99%

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Clinical Correlation of Oral Candidosis and Oral Lichen Planus

et al. 2015

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Lichen planus is a chronic infl ammatory mucocutaneous disease of unclear aetiology. The disease often affects the oral mucosa and may manifest many clinical characteristics, being classifi ed as typical and atypical forms. More importantly, lichen planus has the potential for malignant transformation. Candidosis is the most common disease in the mouth, Candida albicans being the main organism found. Candida sp. may secondarily infect oral lesions such as leukoplakia, oral lichen planus and squamous cell carcinoma. Patients with oral lichen planus (OLP) frequently present Candida infection. Superimposed candidosis lesions can interfere on the diagnosis of OLP, because the organism Candida albicans can change the reticular pattern characteristic of OLP. So, the aim of this chapter is to review the literature on the association of candidosis and oral lichen planus.

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Proliferation and Apoptosis of Peripheral Blood Mononuclear Cells in Patients with Oral Lichen Planus

Shan

Wang

et al. 2012

Inflammation

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Oral lichen planus (OLP) is generally accepted to be a T cell-mediated chronic inflammatory disease with an unclear pathogenesis. There have been numerous studies on the proliferation and apoptosis of T cells in situ. In contrast, research on the proliferation and apoptosis of peripheral blood mononuclear cells (PBMCs) in patients with OLP is rare. The aim of the present study was to investigate the proliferation and apoptosis of PBMCs in patients with OLP. PBMCs were isolated from 20 patients with reticular OLP, 20 patients with atrophic-erosive OLP, and 20 healthy volunteers. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2,5-tetrazolium bromide assays were performed to investigate the proliferation of PBMCs, and caspase-3 colorimetric assays were performed to investigate the apoptosis of PBMCs. The proliferation rate of PBMCs in atrophic-erosive OLP subjects was significantly higher than that in both healthy (P < 0.05) and reticular OLP (P < 0.05) subjects. In contrast, the proliferation rate of PBMCs in reticular OLP subjects was significantly lower than that in healthy subjects (P < 0.05). The apoptosis rates of PBMCs in OLP subjects (P < 0.05) and atrophic-erosive OLP subjects (P < 0.05) were significantly lower than the apoptosis rate in the healthy group. Our findings reinforce the view that T cell-mediated immune responses play a critical role in the pathogenesis of OLP. It can reasonably be concluded that these abnormalities are linked to the presence of inflammatory infiltrates.

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Líquen plano bucal: considerações clínicas e histopatológicas

Cited by 15 publications

References 37 publications

Estudo epidemiológico das doenças dermatológicas imunologicamente mediadas na cavidade oral

Estudo epidemiológico das doenças dermatológicas imunologicamente mediadas na cavidade oral

Clinical Correlation of Oral Candidosis and Oral Lichen Planus

Proliferation and Apoptosis of Peripheral Blood Mononuclear Cells in Patients with Oral Lichen Planus

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