Matriz Metaloproteinase 2: um importante marcador genético para colesteatomas

Morales, Douglas Salmazo Rocha; Penido, Norma de Oliveira; Silva, Ismael Dale Coltrin Guerreiro da; Stávale, João Norberto; Guilherme, Arnaldo; Fukuda, Yotaka

doi:10.1590/s0034-72992007000100009

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Both collagenase activity and the pressures applied on the bone walls of the middle ear are factors that may explain the bone erosion that accompanies cholesteatomas 1,4 ,. Collagenases are currently referred to as metalloproteinases and are present in middle ear cholesteatoma perimatrix 14 .…”

Section: Discussionmentioning

confidence: 99%

Análise dos padrões histopatológicos do colesteatoma adquirido da orelha média

Alves¹,

Pereira²,

Ribeiro

et al. 2008

Rev. Bras. Otorrinolaringol.

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Mi ddle ear cholesteatomas are characterized by the presence of stratified squamous epithelium in this cavity with highly invasive properties causing bone destruction and it may lead to complications. Aim: To study the histopathological features in acquired cholesteatomas of the middle ear, correlating this data with patient age. Study design:clinical and experimental cross-sectional study. Material and Methods: Samples were obtained from 50 patients submitted to otologic surgery for the removal of middle ear cholesteatomas from 2006 to 2007. Thirty four patients were adults and 16 were children. Samples were studied by histological analysis. Results: we found the presence of epithelial atrophy (78%), epithelial acanthosis (88%), hyperplasia of the basal layer (88%) and formation of epithelial cones (62%). There was a positive and significant correlation between histopathological variables (such as epithelial acanthosis, hyperplasia of the basal layer and formation of epithelial cones). Histopathological variables presented no statistical significant difference in both age groups (p>0,05). Conclusion: Cholesteatomas have hyperproliferating characteristics with epithelial acanthosis, hyperplasia of the basal layer and the presence of epithelial cones in the matrix.

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Section: Discussionmentioning

confidence: 99%

Análise dos padrões histopatológicos do colesteatoma adquirido da orelha média

Alves¹,

Pereira²,

Ribeiro

et al. 2008

Rev. Bras. Otorrinolaringol.

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“…In people with acute myocardial infarction, an increase of 39% in the probability of ventricular remodeling was reported for each elevation of one unit in MMP 2 level (Cogni et al 2013). This substance behaves in a similar fashion when other tissues undergo either pathological or physiological remodeling (Navarro et al 2006, Morales et al 2007.…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy

et al. 2018

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RESUMO.-[Metaloproteinases de matriz 2 e 9 em coelhos com cardiomiopatia induzida pela doxorrubicina.] Alguns estudos já demonstraram o papel exercido pelas metaloproteinases de matriz e seus inibidores na cardiotoxicidade promovida pela doxorrubicina. Assim, este estudo teve como objetivo investigar o comportamento das MMPs 2 e 9 plasmáticas e miocárdicas em coelhos com cardiomiopatia induzida pela doxorrubicina, buscando determinar se há correlação entre a atividade dessas colagenases e o remodelamento cardíaco. A cardiomiopatia foi induzida pela doxorrubicina aplicada por via intravenosa duas vezes por semana ao longo de seis semanas consecutivas. A atividade plasmática das MMPs e o ecocardiograma foram avaliados no momento basal e aos 15 e 45 dias após a primeira aplicação da doxorrubicina. A atividade miocárdica dessas enzimas foi quantificada em apenas nove coelhos aos 45 dias e os resultados comparados Some studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with doxorubicin-induced cardiomyopathy, searching for a correlation between the activity of these collagenases and cardiac remodeling. Cardiomyopathy was induced by doxorubicin given intravenously twice a week for six consecutive weeks. Plasma MMP activity and the echocardiogram were assessed at baseline, and at 15 and 45 days after first injection of doxorubicin. The myocardial activity of these enzymes was solely evaluated in nine rabbits at 45 days, and results were compared with nine healthy controls. We only identified the full-length forms of both MMP 2 and 9 throughout the study. The plasma pro-MMP 2 reduced along the deterioration of cardiac function, while the pro-MMP 9 increased significantly at T45 as compared to baseline and T15. A negative significant correlation was found to exist between the plasma activity of pro-MMP 2 and mitral E-to-mitral septal annular early diastolic velocity ratio, which is an estimate of mean left atrial pressure and congestion. Only pro-MMP 2 was found in myocardial samples, and mean activity of such enzyme was statistically lower than that recorded for healthy controls. Although no active form was documented for either collagenase, the duration of the treatment with doxorubicin played a role in the alteration of plasma pro-forms activity. However, these changes could not be associated with most echocardiographic parameters that are supportive of cardiac remodeling. Matrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy com outros nove controles saudáveis. Foram identificadas apenas as formas inativas das MMPs 2 e 9 durante todo o estudo. A pro-MMP 2 plasmática reduziu à medida que a função cardiaca se deteriorou, enquanto a pro-MMP 9 aumentou significativamente em T45 quando comparada aos momentos basal e T15. Houve correlação negativa significativa entre a atividade plasmática da pro-MMP 2 e a relação entre E mitral e a ...

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“…Both collagenase activity and the pressures applied on the bone walls of the middle ear are factors that may explain the bone erosion that accompanies cholesteatomas 1 , 4 ,. Collagenases are currently referred to as metalloproteinases and are present in middle ear cholesteatoma perimatrix 14 .…”

Section: Discussionmentioning

confidence: 99%