Análise dos padrões histopatológicos do colesteatoma adquirido da orelha média

Abstract

Mi ddle ear cholesteatomas are characterized by the presence of stratified squamous epithelium in this cavity with highly invasive properties causing bone destruction and it may lead to complications. Aim: To study the histopathological features in acquired cholesteatomas of the middle ear, correlating this data with patient age. Study design:clinical and experimental cross-sectional study. Material and Methods: Samples were obtained from 50 patients submitted to otologic surgery for the removal of middle ear cholesteatomas from 2006 to 2007. Thirty four patients were adults and 16 were children. Samples were studied by histological analysis. Results: we found the presence of epithelial atrophy (78%), epithelial acanthosis (88%), hyperplasia of the basal layer (88%) and formation of epithelial cones (62%). There was a positive and significant correlation between histopathological variables (such as epithelial acanthosis, hyperplasia of the basal layer and formation of epithelial cones). Histopathological variables presented no statistical significant difference in both age groups (p>0,05). Conclusion: Cholesteatomas have hyperproliferating characteristics with epithelial acanthosis, hyperplasia of the basal layer and the presence of epithelial cones in the matrix.

TNF-R2 expression in acquired middle ear cholesteatoma

“…These patterns frequently coexist in the same fragment, as shown in the present study. These histological findings are in agreement with what has been published in the literature 2, 4 .…”

“…These patterns frequently coexist in the same fragment, as shown in the present study. These histological findings are in agreement with what has been published in the literature 2,4 . The evaluation of the peri-matrix from the cholesteatoma fragments reported inflammatory process present in 96.9% of the cases, in different severities.…”

“…Histological analysis of the cholesteatoma matrix may show different patterns: atrophy, acanthosis, basal layer hyperplasia and epithelial cones. It is common to find many of these patterns occurring at the same time in the same patient 2 . Because of its capacity to cause bone erosion, present in 80% of the cases 5 , the cholesteatoma is responsible for extracranial and intracranial complications.…”

“…The middle ear acquired cholesteatoma was first described by, Curveilhier, in 182 9 1 , and it is characterized by tympanic cavity invasion by a keratinized squamous epithelium, which is different from the columnar pseudostratified ciliated epithelium, with goblet cells present near the auditory tube or the simple, cubic or columnar squamous cell epithelium - of the remaining middle ear 2 . Histologically, cholesteatomas may be broken down into matrix (epithelium) and peri-matrix (underlying connective tissue) 3 .…”

“…Histological analysis of the cholesteatoma matrix may show different patterns: atrophy, acanthosis, basal layer hyperplasia and epithelial cones. It is common to find many of these patterns occurring at the same time in the same patient 2 .…”