Eficácia da N-butilescopolamina e dipirona sódica associadas ao cetoprofeno no alívio da dor pós-operatória de pacientes submetidas a duas técnicas diferentes de laqueadura por laparoscopia

Ganem, Eliana Marisa; Salem, Isabel C F; Fukushima, Fernanda Bono; Nakamura, Giane; Dias, Rogério; Fontana, André L; Leite, Nilton José

doi:10.1590/s0034-70942005000400004

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…During a laparoscopy, phrenic neuritis occurs from the compression of the diaphragm as a result of CO 2 pneumoperitoneum, peritoneal fluid acidosis, and mechanoreceptors of the visceral smooth muscles (Aδ and C) responsible for the tension applied to the peritoneum (Lamont & Tranquili, 2000). Additionally, direct trauma to vessels, traction on nerves, and inadvertent sudden peritoneal distention may cause pain during laparotomies (Ganem et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

“…Sodium dipyrone, or metamizol, reduces pain by inhibiting prostaglandin synthesis in the peripheral and central nervous system (Chandrasekharan, Dai, Roos, & Evanson, 2002). N-butylscopolamine bromide treats colic by acting on smooth abdominal and pelvic muscles and affecting their intramural parasympathetic ganglia (Ganem et al, 2005). Meloxicam is a predominantly COX-2 selective NSAID.…”

Section: Introductionmentioning

confidence: 99%

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Dipyrone, scopolamine, and meloxicam for conventional or two-port laparoscopic-assisted ovariohysterectomy in female dogs

Dalmolin

Oliveira

Filho

et al. 2020

SCA

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For ethical and organic reasons, surgical and analgesic techniques that minimize and adequately control pain should be studied. Ovariohysterectomy is the most common surgical technique in veterinary medicine and is performed in female dogs for elective or therapeutic purposes. Both conventional and minimally invasive surgical techniques are used in veterinary medicine; however, the minimally invasive laparoscopic technique is considered superior to the conventional technique because it is associated with a less painful and faster post-operative recovery. However, for various reasons, the laparoscopic technique is not yet widely used in veterinary medicine, and the conventional ovariohysterectomy is still the most common. The aim of this study, therefore, was to validate the efficacy of the combination of dipyrone, scopolamine, and meloxicam after conventional or two-port laparoscopic-assisted ovariohysterectomies in female dogs. Additionally, this study sought to assess recovery after the two surgical modalities while receiving the same analgesic protocol. Fourteen healthy adult female dogs were spayed and then evaluated using the Visual Analogue Scale, the Melbourne Scale, and the short form of the Glasgow Composite Measure Pain Scale for 72 hours after surgery. The analgesic protocol was efficient for pain control after both techniques, with minimal differences between the groups.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dipyrone, scopolamine, and meloxicam for conventional or two-port laparoscopic-assisted ovariohysterectomy in female dogs

Dalmolin

Oliveira

Filho

et al. 2020

SCA

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“…N-butylscopolamine bromide treat pain from colic in humans, because it acts in smooth abdominal and pelvic muscles by affect the intramural parasympathetic ganglion of smooth abdominal and pelvic muscle [9]. There is a lack of information about the use of metamizol and scopolamine combination in dogs, although in Brazilian routine, the commercial combination of these drugs is used in veterinary routine in order to control post operatory pain.…”

Section: Introductionmentioning

confidence: 99%

Metamizol and Scopolamine for Conventional or Two-Port Laparoscopic-Assisted Ovariohysterectomy in Dogs

Dalmolin

Oliveira

Filho

et al. 2020

Acta Scientiae. Vet.

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Background: Ovariohysterectomy (OVH) is one of the most appliedtechniques in Veterinary Medicine. Although some analgesic protocols are used after this procedure in order to control post operatory pain, there is a lack of knowledge of the efficacy after conventional and two port laparoscopic-assisted techniques in dog female. Although the combined formulation of metamizol and scopolamine is used, there is no knowledge about the efficacy and collateral effects in a 6 h regimen after OVH. The aim of this research was to evaluate the efficacy of metamizol and scopolamine to analgesia after two techniques of OVH in dog female.Materials, Methods & Results: Fifteen adults and healthy dog female were submitted to OVH, being eight to the conventional procedure and seven to video assisted technic with two ports. The patients received a combination of metamizol and scopolamine, 6-6 h during 48 h and were evaluated before surgery, 60 min after extubation and on 1 h interval during the first 8 h, and at 12, 18, 24, 36, 48 and 72 h after surgery. For this, the University of Melbourne Pain Scale (UMPS) and the short-form of the Glasgow Composite Measure Pain Scale (CMPS-SF) were applied by three evaluators blinded to surgical technic. Glucoses measurement was realized at 1, 6, 12, 24, 48 and 72 h after surgery. Analgesic rescue was not necessary for any animal. Punctuation of UMPS in GC decreases at 8 h and at 5 h, and to GV at 12 and 24 h. Difference between groups happened at 3 h with larger average to GV; at 48 h the punctuation in GC was lager. Considering CMPS-SF to CG, higher average was observed at 1 h and decreased at 2, 3, 8 and 18. At GV highest average points was verified at 1, 2 and 3 h and decreased at 5, 8 and 18 h. Correlation was strong and positive between each two evaluators. Animals of both groups had increased average glucose concentrations from baseline to after surgery and the values reduced to baseline after 24 h; difference between groups were observed at 1 h after surgery, with bigger average to GC. Three animals from the GC had postoperative emesis and one patient vomited after 3 h; other at 6 h and another at 36 and 48 h and owners related no vomiting or changes following hospital discharge. The time to first spontaneous food intake was earlier to GV and time to first defecation was no different between groups. Discussion: For the evaluation it was used the UMPS and CMPS-SF since it is know that pain assessment is better performed when multidimensional or composite scales are used. Considering the UMPS, 27 points is considered the most painful condition. In our study it was observed bigger average to GC at 1 h (4,5) and to GV at 2 and 3 h (5,0). According to CMPS-SF, higher punctuation to GC (7.0) was observed than GV (6,0) in a maximum of 24 points. Considering both scales, it could be suggested that the combination of metamizol and scopolamine promote good analgesic effect. The glucoses measurements and the first spontaneous food intake suggested that laparoscopic approaches results in less stress than the traditional procedures, as observed in other studies. Three animals of GC had postoperative emesis, and it signal can be associated to abdominal pain, as well nausea, vomiting, diarrhea and abdominal distention, probably because it is accepted that video surgery promotes less pain and stress than open procedures. The protocol was efficient to control pain after elective conventional and laparoscopic assisted OHV technique in dog female.

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Eficácia da N-butilescopolamina e dipirona sódica associadas ao cetoprofeno no alívio da dor pós-operatória de pacientes submetidas a duas técnicas diferentes de laqueadura por laparoscopia

Abstract: JUSTIFICATIVA E OBJETIVOS: A laqueadura laparoscópica (LL) é um dos procedimentos mais dolorosos e a intensidade da dor varia com a técnica selecionada, sendo mais intensa com a técnica de oclusão das tubas uterinas com anel. As pacientes submetidas à LL referem dor em

Cited by 2 publications

References 18 publications

Dipyrone, scopolamine, and meloxicam for conventional or two-port laparoscopic-assisted ovariohysterectomy in female dogs

Dipyrone, scopolamine, and meloxicam for conventional or two-port laparoscopic-assisted ovariohysterectomy in female dogs

Metamizol and Scopolamine for Conventional or Two-Port Laparoscopic-Assisted Ovariohysterectomy in Dogs

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