“…The potent analgesic effect of dipyrone in dogs is well-known and it is mainly related to the inhibition of the cyclooxygenase (COX) enzyme, and consequent decrease in prostaglandin synthesis, resulting in the reduced sensitivity of nerve endings to inflammatory mediators such as bradykinin. Several studies have found that dipyrone is effective as an analgesic in postoperative pain in dogs undergoing removal of tumors, ovarian hysterectomy, and splenic torsion (Caulkett et al, 2003;Imagawa et al, 2011;Zanuzzo et al, 2015;Guerrero et al, 2015;Bellio et al, 2015;Souza et al, 2016;Ortiz et al, 2016;Ferrigno et al, 2016;Sembenelli et al, 2016;Dalmolin et al, 2020). For Ripplinger et al (2018), the association of metamizole and morphine or metamizole and methadone did not result in an increase in adverse effects in dogs when compared to animals treated with morphine or methadone alone.…”