Correlação entre concentração liquórica e efeitos colaterais após injeção de morfina por via subaracnóidea em ratos

Silva, Neuzimar de Souza Freire; Sakata, Rioko Kimiko; Issy, Adriana Machado

doi:10.1590/s0034-70942004000100007

Cited by 2 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Respiratory variables have been shown to be greatly altered by morphine (Valadão et al, 2002;Silva et al, 2004;Pereira and Marques, 2009), however, our results showed stability of the studied parameters (f R , SpO 2 , FiO 2 e P E´C O 2 ). Yaksh et al (2000) corroborates these results for having observed minimal changes in respiratory variables after epidural administration of morphine at 5mg in 0.9% sodium chloride.…”

Section: Discussioncontrasting

confidence: 42%

“…The morphine and levobupivacaine curves behaved similarly to one another. Levels decreased along with the duration of local anesthesia as described by Silva et al (2004), who observed gradual reduction of morphine levels after subarachnoid administration of 0.1, 0.3, 0.5 and 1.µg in rats. The authors found serum morphine concentrations of 7.38, 114.26, 151.18 and 561.37 pg 100µL -1 respectively, 60 minutes after injection.…”

Section: Discussionmentioning

confidence: 56%

“…However, Silva et al (2004) have observed different results, with severe bradycardia after epidural morphine at 0.1mg kg -1 . Leone et al (2009) have reported that local anesthetics of longer duration, such as levobupivacaine and bupivacaine, may cause a dose-dependent prolongation of cardiac conduction, which leads to increased PR and QRS intervals at the electrocardiogram.…”

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Albuquerque¹,

Araújo²,

Ferreira³

et al. 2015

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

The aim of this study was to assess the cardiopulmonary, analgesic, adverse effects, serum concentration of cortisol and plasma levels of levobupivacaine and morphine in bitches undergoing propofol anesthesia and epidural analgesia with levobupivacaine alone or combined with morphine. This was a randomized 'blinded' prospective clinical study using 32 adult bitches weighing 9.8±4.1kg that were admitted for elective ovariohysterectomy. Twenty minutes after administration of acepromazine and midazolam, anesthesia was induced with propofol (4mg kg -1 ) and maintained by a continuous rate infusion (CRI). Each animal was randomly assigned to one of four epidural groups: GL = levobupivacaine alone (0.33mg kg -1 ); GLM0.1 = levobupivacaine and morphine (0.1mg kg -1 ); GLM0.15 = levobupivacaine and morphine (0.15mg kg -1 ); and GLM0.2 = levobupivacaine and morphine (0.2mg kg -1 ). Variables obtained during anesthesia were heart rate, respiratory rate, systolic, mean and diastolic arterial blood pressures, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, blood gases, serum cortisol, and plasma levels of levobupivacaine and morphine. The onset and duration times of the blockade were recorded. Arterial pressures were significantly increased in all groups at the times of ovarian pedicle clamping. There was a decrease in pH, together with an increase in both PaO 2 and PaCO 2 over time. Serum cortisol levels were increased in TESu compared to TB, T30 and TR. Limb spasticity, muscle tremors, opisthotonos and diarrhea were observed in some animals during propofol infusion and ceased with the end of CRI. Reactions happened at different moments and lasted for different periods of time in each individual. Epidural with levobupivacaine alone or combined with morphine allowed for ovariohysterectomy to be performed under low propofol infusion rates, with minimal changes in cardiovascular variables and in serum cortisol levels. Adverse effects were observed in very few animals in each group. Keywords: dog, opioid, ovariohysterectomy, blood gas, regional anaesthesia (0,33mg/kg); GLM0,1 = levobupivacaína + morfina (0,1mg/kg); GLM0,15 = levobupivacaína + morfina (0,15mg/kg) e GLM0,2 = levobupivacaína + morfina (0,2mg/kg RESUMO Objetivou-se avaliar os efeitos cardiovasculares, analgésico, adversos, a concentração sérica de cortisol e os níveis plasmáticos de levobupivacaína e morfina em cadelas submetidas à infusão contínua de propofol e analgesia peridural com levobupivacaína isolada ou associada à morfina. Para tanto, realizou-se um estudo clínico prospectivo randomizado com 32 cadelas adultas pesando 9,8 ± 4,1kg, que foram submetidas à ovário-histerectomia eletiva. Vinte minutos após a administração de acepromazina e midazolam, os animais foram induzidos com propofol (4mg/kg) e mantidos por uma infusão contínua (CRI) do mesmo fármaco. Cada animal foi alocado aleatoriamente em um dos quatro grupos: GL = levobupivacaína isolada

show abstract

Section: Discussioncontrasting

confidence: 42%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Albuquerque¹,

Araújo²,

Ferreira³

et al. 2015

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

show abstract

“…The lower numbers in this study could be ascribed to the opioid added to ropivacaine, which has also been observed by Albuquerque et al 5 this study 5 . The hydrophilic property of morphine can be a reason for longer duration of effect 15 .…”

Section: Resultsmentioning

confidence: 99%

Effects of ropivacaine combined with morphine at 0.15 and 0.2 mg kg-1 in bitches undergoing epidural anesthesia

Albuquerque

Araújo²,

Ferreira

et al. 2015

Acta Cir. Bras.

View full text Add to dashboard Cite

Conception, design, intellectual and scientific content of the study, critical revision. ABSTRACT PURPOSE:To investigate cardiorespiratory effects and serum concentration of ropivacaine combined with morphine at different doses. METHODS:Sixteen healthy adult female dogs weighting 9.8±4.1 kg were included in the study. Twenty minutes after being premedicated with acepromazine and midazolam, the animals were randomly assigned to receive an epidural injection according to each group: RM0.15 = ropivacaine + morphine (0.15 mg kg -1 ) and RM0.2 = ropivacaine + morphine (0.2 mg kg -1 ). Variables recorded consisted of: heart rate and cardiac rhythm, respiratory rate, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, systolic, mean and diastolic arterial pressures, serum cortisol, plasma ropivacaine and morphine.RESULTS: SAP, MAP and DAP were significantly increased at TPR in RM0.15 but returned to normal values at the end of the procedure. Arterial pH was decreased in T30 and TESu in both groups and also returned to acceptable ranges at TR. Both PaO 2 and PaCO 2 were increased along the duration period of the epidural blockade (T30 and TESu) and returned to acceptable values at TR.Serum cortisol was lower at TB, T30 and TR when compared to TESu. CONCLUSION:The procedures were performed safely and minimal changes in cardiovascular and respiratory variables.

show abstract

Correlação entre concentração liquórica e efeitos colaterais após injeção de morfina por via subaracnóidea em ratos

Abstract: There has been no correlation between CSF morphine concentration and side effects.

Cited by 2 publications

References 4 publications

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Effects of ropivacaine combined with morphine at 0.15 and 0.2 mg kg-1 in bitches undergoing epidural anesthesia

Contact Info

Product

Resources

About