Comparação da eficácia de doses iguais de acetaminofeno retal e oral em crianças

Abstract

Objective: To compare a dose of oral and rectal acetaminophen and to evaluate acceptability of rectal acetaminophen, since oral and rectal acetaminophen is widely used as an antipyretic agent in febrile children and the comparative effectiveness of these two preparations is not well established. Methods:In this prospective parallel group designed study, 60 children who presented to the emergency department or outpatient pediatric clinic at a tertiary hospital and aged from 6 months to 6 years with rectal temperature over 39 °C were enrolled. Patients were randomly assigned to two equal-sized groups. Group 1 received 15 mg/kg acetaminophen rectally and group 2 received the same dose orally. Temperature was recorded at baseline and 1 and 3 hours after drug administration. Results:In the first group, mean decrease in temperature, 1 and 3 hours after administration of acetaminophen was 1.07±0.16 (p < 0.001) and 1.74±0.25 °C (p < 0.001), respectively, and in the second group it was 1.98±0.19 (p < 0.001) and 1.70±0.14 °C (p < 0.001), respectively (p > 0.05). Conclusion:Rectal and oral acetaminophen preparations have equal antipyretic effectiveness in children. The rectal route proved to be as acceptable as the oral one among parents. J Pediatr (Rio J). 2010;86(3):228-232:Oral acetaminophen, rectal acetaminophen, fever.

Rectal Diclofenac Versus Rectal Paracetamol: Comparison of Antipyretic Effectiveness in Children

“…These differences are hard to explain as the same drugs, dose and methods had been used. However the initial body temperature (39°C in the study of Karbasi et al ( 17 ) and 38°C in our study) could be the cause of these differences.…”

“…Oral and rectal forms of Paracetamol are among the most popular and widely used over-the-counter drugs for the treatment of pain and fever, especially in the pediatric population ( 13 , 14 ). In previous studies, the antipyretic effect of rectal paracetamol has been well established, yet the antipyretic effect after one hour of administration has not been clarified ( 15 - 17 ). To best of our knowledge, only one study has reported a decrease in body temperature one hour following the administration of Paracetamol with an average of 1.07 ± 0.16°C, which is significantly more than what we detected in our survey (0.65 ± 0.17 °C) ( 17 ).…”

“…In previous studies, the antipyretic effect of rectal paracetamol has been well established, yet the antipyretic effect after one hour of administration has not been clarified ( 15 - 17 ). To best of our knowledge, only one study has reported a decrease in body temperature one hour following the administration of Paracetamol with an average of 1.07 ± 0.16°C, which is significantly more than what we detected in our survey (0.65 ± 0.17 °C) ( 17 ). These differences are hard to explain as the same drugs, dose and methods had been used.…”

Antipyretics in the emergency department - intravenous paracetamol versus intramuscular diclofenac: a comparative study

“…Fever is a common problem in adults visiting the emergency department (ED) [1]. Although it is important to treat the cause of fever, symptomatic management of fever is also necessary.…”

“…Although it is important to treat the cause of fever, symptomatic management of fever is also necessary. Multiple studies are available on the efficacy of various antipyretics in children, but very little has been done in adults [1],[2]. Hence we aimed to compare the antipyretic efficacy of intravenous (i.v.)…”