Asma nas etapas iniciais da vida: a hipótese da higiene está correta?

Weiss, Scott T.

doi:10.1590/s0021-75572008000700002

Cited by 11 publications

(1 citation statement)

References 2 publications

(2 reference statements)

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“…In many regions of Latin America asthma is a public health problem affecting children and adolescents in urban areas; wheezing, asthma and allergic rhinitis are very frequent in some regions [3], with rates similar or even higher than in industrialized countries [4,5]. Interestingly, anticipated protective factors, such as low hygienic conditions, do not confer protection in poor and overcrowded communities, where a high prevalence of asthma and early infections concur [6-8]. In addition, there are disparities among some phenotypes, such as allergic sensitization and prevalence of atopic eczema, when compared to those observed in industrialized countries [9,10].…”

Section: Introductionmentioning

confidence: 99%

Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study

et al. 2012

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Background: Early wheezing and asthma are relevant health problems in the tropics. Mite sensitization is an important risk factor, but the roles of others, inherent in poverty, are unknown. We designed a birth-cohort study in Cartagena (Colombia) to investigate genetic and environmental risk factors for asthma and atopy, considering as particular features perennial exposure to mites, parasite infections and poor living conditions. Methods: Pregnant women representative of the low-income suburbs of the city were randomly screened for eligibility at delivery; 326 mother-infant pairs were included at baseline and biological samples were collected from birth to 24 months for immunological testing, molecular genetics and gene expression analysis. Pre and post-natal information was collected using questionnaires.

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Section: Introductionmentioning

confidence: 99%

Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study

et al. 2012

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Maternal Infection in Pregnancy and Risk of Asthma in Offspring

Collier

Risnes

Norwitz

et al. 2013

Matern Child Health J

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This study estimates the effect of maternal infections during pregnancy on childhood asthma. One-thousand four-hundred and twenty-eight pregnant women were prospectively followed using structured interviews and chart review until their child's 6th year of life. Infections were identified from outpatient and hospital visits. Childhood asthma was defined as physician diagnosis with symptoms at age six. Adjusted odds ratios were calculated from multivariable logistic regression models. Six-hundred and thirty-five women experienced an infection during pregnancy. Among antepartum infections, maternal urinary tract infections were significantly associated with childhood asthma (aOR 1.60, 95 % CI 1.12-2.29). Chorioamnionitis and maternal group beta streptococcus colonization were not significantly associated with an increased risk in childhood asthma. This study found an increased risk of asthma in children of women diagnosed with urinary tract infections during pregnancy, while other maternal infections did not increase the risk.

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Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

Arshad

2009

Curr Allergy Asthma Rep

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Common indoor allergens include house dust mite, cockroach, animal dander, and certain molds. In genetically susceptible children, exposure to these indoor allergens during the critical postnatal period may lead to sensitization in early childhood. Consistent evidence indicates that children sensitized to common indoor allergens are at several-fold higher risk of asthma and allergy. Due to conflicting evidence from prospective studies, some doubt remains regarding a direct and dose-response relationship between exposure and development of asthma. However, in recent years, evidence has accumulated that exposure to indoor allergen causes asthma and allergy, but this effect may depend on dose and type of allergen as well as the underlying genetic susceptibility of the child.

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Asma nas etapas iniciais da vida: a hipótese da higiene está correta?

Abstract: 9. Lord C. Follow-up of two-year-olds referred for possible autism.

Cited by 11 publications

References 2 publications

Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study

Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study

Maternal Infection in Pregnancy and Risk of Asthma in Offspring

Does Exposure to Indoor Allergens Contribute to the Development of Asthma and Allergy?

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