Proteína C reativa como indicador de inflamação de baixa intensidade em crianças e adolescentes com e sem obesidade

OBJECTIVE: To investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents. METHODS: Cross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive C-reactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%. RESULTS: Altered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005). CONCLUSION: High prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.

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“…Norton et al 20 in a study with 131 obese or overweight children and adolescents showed similar results (26.7%) of us-CRP >3 mg/dL.…”

Section: Discussionmentioning

confidence: 53%

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cardoso

Carvalho

et al. 2014

Rev. Nutr.

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“…The detection limit of this assay was 0.20 mg/L with measuring range of 0.18 to 1150 mg/L with intra-assay and inter-assay coefficients of variance of 2.65% and 3.6%, respectively. The hs-CRP values >10 mg/L were excluded to avoid influence of acute infection [29]. Hemoglobin A 1c (HbA 1c ) level was determined by the Bayer DCA (Bayer Diagnostics Inc, Tarrytown, NY) 2000 instrument (non-diabetic range of 4.5% to 5.7%).…”

Section: Introductionmentioning

confidence: 99%

Gender differences in the association of insulin resistance and high-sensitivity c-reactive protein in obese adolescents

Alemzadeh

Kichler

2014

J Diabetes Metab Disord

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BackgroundLow-grade vascular inflammation is believed to initiate early atherosclerotic process by inducing insulin resistance (IR), with significant gender differences in adults. We evaluated the relationship between surrogate measures of inflammation and IR in obese adolescents.MethodsThe association among markers of inflammation [high-sensitivity c-reactive protein (hs-CRP)] and IR, cardiometabolic risk factors and body composition was retrospectively examined in 199 obese adolescents [(111 F/88 M), aged 15.5 ± 1.2 years]. Insulin resistance was assessed using homeostatic model assessment for insulin resistance (HOMA-IR).ResultsMales had higher body mass index SD-score (BMI-SDS), fat mass (FM), glucose, insulin, HOMA-IR, HbA1c, hs-CRP, triglycerides: HDL-C (TG:HDL-C) ratio than females (p < 0.05), whereas females had higher c-peptide: insulin ratio than males (p < 0.05). Also, 50.8% of subjects were identified with metabolic syndrome with similar gender distribution (M: 57.9% vs. F: 45.1%, p = 0.32). Hs-CRP was correlated with HOMA-IR in the cohort, even when controlling for FM (r = 0.26; p < 0.0001). However, hs-CRP and HOMA-IR displayed a significant correlation only in females (r = 0.37; p < 0.0001) when adjusting for FM and pubertal status. Also, c-peptide: insulin ratio was inversely correlated with hs-CRP (r = −0.32; p < 0.001) and HOMA-IR (r = −0.62; p < 0.0001) and partially mediated the relationship between these biomarkers only among females (β = 0.36, p < 0.001 to β = 0.18, p < 0.05; Sobel Test: p < 0.01).ConclusionsA positive association between hs-CRP and HOMA-IR was observed only in adolescent girls which was influenced by altered hepatic insulin clearance. This implies that obese adolescent girls may be at greatest risk of developing early atherosclerosis and diabetes.

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“…In children, the presence of obesity has been associated with increased levels of high sensitivity CRP (hsCRP) [4], as well as other inflammatory mediators [5-9], all of which promote the development of endothelial and metabolic dysfunction [10-14]. However, substantial variability is found among obese children as to the presence of metabolic dysfunction or increased inflammatory markers, suggesting that individual genomic variance may account for such discrepancies.…”

Section: Introductionmentioning

confidence: 99%

Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels

et al. 2010

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IntroductionObesity increases the risk for insulin resistance and metabolic syndrome in both adults and children. FABP4 is a member of the intracellular lipid-binding protein family that is predominantly expressed in adipose tissue, and plays an important role in maintaining glucose and lipid homeostasis. The purpose of this study was to measure FABP4 plasma levels, assess FABP4 allelic variants, and explore potential associations with fasting glucose and insulin levels in young school-age children with and without obesity.MethodsA total of 309 consecutive children ages 5-7 years were recruited. Children were divided based on BMI z score into Obese (OB; BMI z score >1.65) and non-obese (NOB). Fasting plasma glucose, lipids, insulin, hsCRP, and FABP4 levels were measured. HOMA was used as correlate of insulin sensitivity. Four SNPs of the human FABP4 gene (rs1051231, rs2303519, rs16909233 and rs1054135), corresponding to several critical regions of the encoding FABP4 gene sequence were genotyped.ResultsCompared to NOB, circulating FABP4 levels were increased in OB, as were LDL, hsCRP and HOMA. FABP4 levels correlated with BMI, and also contributed to the variance of HOMA and hsCRP, but not serum lipids. The frequency of rs1054135 allelic variant was increased in OB, and was associated with increased FABP4 levels, while the presence of rs16909233 variant allele, although similar in OB and NOB, was associated with increased HOMA values.ConclusionsChildhood obesity is associated with higher FABP4 levels that may promote cardiometabolic risk. The presence of selective SNPs in the FABP4 gene may account for increased risk for insulin resistance or systemic inflammation in the context of obesity.

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Proteína C reativa como indicador de inflamação de baixa intensidade em crianças e adolescentes com e sem obesidade

Cited by 29 publications

References 11 publications

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Gender differences in the association of insulin resistance and high-sensitivity c-reactive protein in obese adolescents

Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels

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