O papel dos probióticos e prebióticos na prática pediátrica

Abstract

Objective: To review the effects of probiotics and prebiotics in clinical pediatric practice.Sources: MEDLINE was searched, especially for articles that addressed their practical application, in the form of reviews, clinical trials and meta-analyses. Articles that had already been analyzed by the authors were also included.Summary of the findings: Scientific literature on probiotics and prebiotics has remarkably increased in the last 10 years. Their mechanisms of action have been experimentally investigated. Studies indicate that probiotics can act by competing with pathogens, modifying the intestinal environment by reduction in pH, as a result of fermentation products, interacting and modulating local and systemic inflammatory and immune response, among others. Clinical trials and meta-analyses show that probiotics seem to contribute towards the prevention of acute diarrhea and of antibioticassociated diarrhea, in addition to shortening the duration of acute diarrhea. However, the data are inconsistent and there are no studies confirming their efficacy in terms of cost-benefit ratio. Preliminary studies show that probiotics in early life can reduce the occurrence of atopic dermatitis. The addition of prebiotics to infant formulas is associated with the change in the profile of the intestinal microbiota compared to infants fed milk formulas without prebiotics. Conclusions:Evidence indicates that new studies should be carried out about probiotics, prebiotics and symbiotics. The specific clinical effects that each probiotic or prebiotic may cause must be considered.J Pediatr (Rio J). 2006;82(5 Suppl):S189-97: Prebiotics, probiotics, symbiotics, lactobacillus, bifidobacteria, diarrhea. REVIEW ARTICLE

Sensory Analysis: Relevance for Prebiotic, Probiotic, and Synbiotic Product Development

“…According to Morais and Jacobs (2006), prebiotics, probiotics, and synbiotics will be the motive of many studies in years to come. The wide range of preventative and therapeutic possibilities is, on one hand, a motive for great enthusiasm, but, on the other hand, the principle that probably exists for each desired effect on the specificity of a determined group of effective agents, should be emphasized.…”

Probióticos e prebiótios na prevenção e tratamentos de doenças

“…Alguns critérios são utilizados para definição de um microrganismo como probiótico: -origem humana; não patogênico; resistência a processamento; estabilidade à secreção ácida e biliar; adesão à célula epitelial; capacidade de persistir no trato gastrintestinal; capacidade de influenciar atividade metabólica local JACOB, 2006).…”

Óleo de aroeira vermelha e de suplementação de vitamina E em substituição aos promotores de crescimento sobre a microbiota intestinal de frangos de corte

“…produzem várias substâncias antimicrobianas, como ácidos orgânicos (como ácido láctico), peróxido de hidrogênio, dióxido de carbono, diacetil, acetaldeído e bacteriocinas (NAIDU et al, 1999), eles também podem ter colaborado na inibição microrganismos patogênicos, conforme descrito por MORAIS & JACOB (2006).…”