Controvérsias a respeito da sepse fúngica no pré-termo extremo: profilaxia e esquemas terapêuticos

Background: Cryptococcus neoformans is the etiologic agent of opportunistic systemic fungal infection cryptococcosis, which affects individuals with compromised immune systems. Thus, natural products research has become important, since monoterpenes such as carvacrol, a promising molecule in the search antifungal agents, have shown significant biological activity. Objective: The study aimed to investigate the antifungal activity and mode of action of carvacrol against strains of C. neoformans. Methods: The minimum inhibitory concentration (MIC) was determined by microdilution method. Minimum fungicidal concentration (MFC) was performed by seeding technique on solid media. Studying the mode of action was performed using broth microdilution. Results: The MIC ranged from 25 to 81 lg/mL and the MFC ranged from 25 to 102 lg/mL. Carvacrol bonded to exogenous ergosterol and cholesterol. Discussion: The results suggest that carvacrol has antifungal activity against C. neoformans and its mode of action is related to fungal membrane instability. Conclusions: The phytoconstituent carvacrol may eventually become a drug; however, further studies are needed to elucidate its mechanism.

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“…This drug acts by binding to ergosterol, leading to increased permeability and ultimately, to cell death (Moreira 2005). Table 1.…”

Section: Resultsmentioning

confidence: 99%

Investigation of the antifungal activity of carvacrol against strains ofCryptococcus neoformans

Nóbrega¹,

Teixeira

Oliveira

et al. 2016

Pharmaceutical Biology

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“…However, there is a new therapeutic class of antifungal drugs for invasive candidiasis. This class is known as the echinocandins, which are showing to be more safe and effective and with fewer side effects than the other drugs; they can be used as an excellent therapeutic option, especially in cases of recent history of exposure to an azole, moderately severe to severe illness (i.e., hemodynamically unstable), and allergy or intolerance to azoles [66][67][68][69][70][71] . Although amphotericin B remains a therapeutic option because of its broad spectrum and low cost, it produces side effects related to infusion and nephrotoxicity [71][72][73] .…”

Section: Discussionmentioning

confidence: 99%

Candida spp. isolated from inpatients, the environment, and health practitioners in the pediatric unit at the Universitary Hospital of the Jundiaí Medical College, state of São Paulo, Brazil

Storti

Pasquale

Scomparim

et al. 2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: This study aimed to isolate and identify Candida spp. from the environment, health practitioners, and patients with the presumptive diagnosis of candidiasis in the Pediatric Unit at the Universitary Hospital of the Jundiaí Medical College, to verify the production of enzymes regarded as virulence factors, and to determine how susceptible the isolated samples from patients with candidiasis are to antifungal agents. METHODS: Between March and November of 2008 a total of 283 samples were taken randomly from the environment and from the hands of health staff, and samples of all the suspected cases of Candida spp. hospital-acquired infection were collected and selected by the Infection Control Committee. The material was processed and the yeast genus Candida was isolated and identified by physiological, microscopic, and macroscopic attributes. RESULTS: The incidence of Candida spp. in the environment and employees was 19.2%. The most frequent species were C. parapsilosis and C. tropicalis among the workers, C. guilliermondii and C. tropicalis in the air, C. lusitanae on the contact surfaces, and C. tropicalis and C. guilliermondii in the climate control equipment. The college hospital had 320 admissions, of which 13 (4%) presented Candida spp. infections; three of them died, two being victims of a C. tropicalis infection and the remaining one of C. albicans. All the Candida spp. in the isolates evidenced sensitivity to amphotericin B, nystatin, and fluconazole. CONCLUSIONS: The increase in the rate of hospital-acquired infections caused by Candida spp. indicates the need to take larger measures regarding recurrent control of the environment.

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“…na região inguinal tem sido realizada, principalmente, com o intuito de se detectar a presença de sinais da doença superficial: piedra branca, especialmente em homens, nos quais se acredita a doença ser prevalente (STENDERUP et al, 1986;HERBRECHT et al, 1993). Trérizol-Ferly et al (1994) (CROCCO et al, 2004;FERRAZZA et al, 2005;ABIA-BASSEY;UTSALO, 2006 (MOREIRA, 2005;PASQUALOTTO et al, 2006).…”

Section: Discussionunclassified

“…A colonização é o mais importante, pois coloca o susceptível em contato direto com o agente infeccioso (MOREIRA, 2005;PAULINO et al, 2006). Candida albicans é a espécie mais conhecida e associada a dermatomicoses em cães e gatos e foi a única espécie isolada na população pesquisada.…”

Section: Discussionunclassified

Leveduras do gênero Trichosporon: aspectos ecológicos, caracterização laboratorial, fatores associados à virulência e suscetibilidade a antifúngicos.

Bentubo¹

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Controvérsias a respeito da sepse fúngica no pré-termo extremo: profilaxia e esquemas terapêuticos

Cited by 7 publications

References 27 publications

Investigation of the antifungal activity of carvacrol against strains ofCryptococcus neoformans

Investigation of the antifungal activity of carvacrol against strains ofCryptococcus neoformans

Candida spp. isolated from inpatients, the environment, and health practitioners in the pediatric unit at the Universitary Hospital of the Jundiaí Medical College, state of São Paulo, Brazil

Leveduras do gênero Trichosporon: aspectos ecológicos, caracterização laboratorial, fatores associados à virulência e suscetibilidade a antifúngicos.

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