Neurological symptoms and signs in HTLV-1 patients with overactive bladder syndrome

Costa, Davi Tanajura; Santos, André Luiz Muniz Alves dos; Castro, Néviton; Siqueira, Isadora Cristina de; Filho, Edgar Marcelino de Carvalho; Glesby, Marshall J.

doi:10.1590/s0004-282x2012000400005

Cited by 14 publications

(11 citation statements)

References 20 publications

(19 reference statements)

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“…19 The Medical Research Council scale is commonly used to evaluate muscle strength in individuals infected with HTLV-1. 16 In the present study, the patients exhibited muscle weakness, which was most evident in the proximal muscles of the lower limbs. This finding is in agreement with data reported in the literature and confirms the initial onset of muscle weakness in the proximal regions of lower limbs, which subsequently spreads to distal regions.…”

Section: Resultsmentioning

confidence: 46%

“…This disease has no cure yet, only palliative treatment to minimize the clinical symptoms. 1,13 The individuals with HTLV-1 treated at the Epidemiological Clinic of Endemic Diseases of the Tropical Medicine Sector of the Federal 14 who employed these criteria to screen patients, and in studies conducted by Starling et al 15 and Costa et al 16 . In the present investigation, as in the aforementioned studies, the patients were screened using the criteria proposed by De Castro-Costa.…”

Section: Resultsmentioning

confidence: 99%

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Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon

et al. 2015

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Study design: A cross-sectional observational study was conducted. Objective:The aim was to analyze the clinical-functional profile of patients diagnosed with HTLV-1 (human T-lymphotropic virus type 1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in the Amazon region. Setting: Reference center for HTLV in the city of Belém, state of Pará, Brazil. Methods: Muscle strength, muscle tone, balance and the need for gait assistance among patients with HAM/TSP were evaluated. Results: Among the 82 patients infected with HTLV-1, 27 (10 men and 17 women) were diagnosed with HAM/TSP. No statistically significant difference in muscle tone or strength was found between the lower limbs. Muscle weakness and spasticity were predominant in the proximal lower limbs. Patients with HAM/TSP are at a high risk of falls (P = 0.03), and predominantly use either a cane or a crutch on one side as a gait-assistance device (P = 0.02). Conclusion: Patients with HAM/TSP exhibit a similar clinical pattern of muscle weakness and spasticity, with a high risk of falls, requiring gait-assistance devices.

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Section: Resultsmentioning

confidence: 46%

Section: Resultsmentioning

confidence: 99%

Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon

et al. 2015

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“…The expanded disability status scale (EDSS) has been used to evaluate the degree of neurologic dysfunction caused by HTLV-1, and a direct correlation between EDSS scores and urinary dysfunction has been revealed 4 . Moreover, pro-viral load and the production of pro-infl ammatory cytokines that characterize HAM/TSP are also seem increased in patients with OAB without HAM/TSP 7,8 . These data suggest that OAB is a common urologic fi nding of HAM/TSP that may precedes full-blown HAM/TSP.…”

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confidence: 99%

The use of botulinum toxin type A in the treatment of HTLV-1-associated overactive bladder refractory to conventional therapy

Neto

Bittencourt

Oliveira

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Urinary symptoms occur in 19% of human T-cell lymphotropic virus type 1 (HTLV-1)-infected patients who do not fulfi ll criteria for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and in almost 100% of HAM/TSP patients. Few studies have evaluated therapies for overactive bladder (OAB) caused by HTLV-1 infection. This case report describes the effect of onabotulinum toxin A on the urinary manifestations of three patients with HAM/TSP and OAB symptoms. The patients were intravesically administered 200 units of Botox®. Their incontinence episodes improved, and their OAB symptoms scores (OABSS) reduced signifi cantly. These data indicate that Botox® should be a treatment option for OAB associated with HTLV-1 infection.

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“…Human T‐cell lymphotropic virus types 1 and 2 belong to the genus Deltaretrovirus, family Retroviridae, and subfamily Orthoretrovirinae . HTLV‐1 began to be described for the first time around 1980 and was the first pathogenic retrovirus to be discovered …”

Section: Introductionmentioning

confidence: 99%

“…However, cases of ID have been reported in adults as well. It is presented as an exudative eruption involving mainly seborrheic areas such as: scalp, forehead, eyelids, paranasal sinuses, external ear, periauricular region, neck, armpits, and inguinal region . Differential diagnosis should be made with atopic dermatitis and seborrheic dermatitis …”

Section: Introductionmentioning

confidence: 99%

Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

et al. 2019

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Introduction Individuals infected with the human T‐cell lymphotropic virus type 1 (HTLV‐1) commonly present skin lesions, which may be a warning sign for the diagnosis of infection. This study describes the most prevalent skin manifestations in HTLV carriers attended at the clinic of Núcleo de Medicina Tropical (NMT) of the Universidade Federal do Pará (UFPA) in Belém, Pará, Brazil. Methods This is a study of a series of cases of patients infected with human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1/2) treated at NMT UFPA between 1999 and 2016. A descriptive analysis of data was applied. Results Among 788 surveyed medical records in the service, 15.10% (n = 119) were referred to the dermatology clinic. From the series of cases that presented with skin lesions, 66.39% were female and 33.61% were male, and the average age of this group was 48 years. There was a predominance of patients with noninfectious inflammatory manifestations (64.2%), followed by infectious ones (24.6%), and 1.58% with lymphoproliferative diseases. As for the group of lesions, 45.26% of the erythematous‐squamous type were observed, followed by dyschromia (24.21%), and eczematous (14.74%). One patient with a diagnosis of adult T‐cell leukemia/lymphoma, another with parapsoriasis, and four with infective dermatitis are highlighted. Conclusion Skin disorders in the HLTV positive patient are important causes of referral to the dermatologist with etiological and skin lesions groups diversity. In the series of cases studied, lymphoproliferatives diseases and infective dermatitis associated with HTLV‐1 were presented as a challenge for the diagnosis and clinical management of these patients.

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Neurological symptoms and signs in HTLV-1 patients with overactive bladder syndrome

Cited by 14 publications

References 20 publications

Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon

Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon

The use of botulinum toxin type A in the treatment of HTLV-1-associated overactive bladder refractory to conventional therapy

Dermatological manifestations in patients with human T‐cell lymphotropic virus at a reference service in Amazon

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