Prevalence of epilepsy in a case series of multiple sclerosis patients

Viveiros, Cynthia Dumas; Alvarenga, Regina Maria Papais

doi:10.1590/s0004-282x2010000500011

Cited by 7 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The characteristics of the 32 included studies are shown in Supplemental Tables 2 and 3. 5 , 7 , 13 – 42 The studies were conducted from 1935 to 2012. Most of the studies were conducted in Europe (central and Western) (16, 50%), followed by Asia (6, 18.7%), North America (5, 15.6%), and South America (2, 6.2%).…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies reported the incidence of epilepsy to range from 0.65% to 5.97% after MS onset in adult-onset MS. 5 , 13 , 15 , 18 , 21 , 22 , 25 , 28 , 30 , 33 – 36 , 38 , 39 , 41 , 42 In pediatric-onset MS the incidence of seizures was 5.98%. 23 Among eight population-based studies the incidence ranged from 0.64% to 7.45% ( Figure 1 , Supplemental Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-four studies reported the prevalence of epilepsy to range from 0.89% to 8.06% (Supplemental Table 2). 5 , 7 , 14 – 17 , 19 – 22 , 24 – 29 , 31 , 32 , 34 – 36 , 38 , 40 , 42 Among the 11 population-based studies the prevalence ranged from 0.89% to 7.48% ( Figure 2 ). Heterogeneity among these studies was substantial ( I 2 = 93.9); the summary estimate of prevalence was 3.09% (95% CI: 2.01–4.16%).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis

et al. 2014

View full text Add to dashboard Cite

Background:Several studies have suggested that comorbid neurologic disorders are more common than expected in multiple sclerosis (MS).Objective:To estimate the incidence and prevalence of comorbid seizure disorders and sleep disorders in persons with MS and to evaluate the quality of studies included.Methods:The PUBMED, EMBASE, Web of Knowledge, and SCOPUS databases, conference proceedings, and reference lists of retrieved articles were searched. Two reviewers independently screened abstracts to identify relevant articles, followed by full-text review of selected articles. We assessed included studies qualitatively and quantitatively (I2 statistic), and conducted meta-analyses among population-based studies.Results:We reviewed 32 studies regarding seizure disorders. Among population-based studies the incidence of seizure disorders was 2.28% (95% CI: 1.11–3.44%), while the prevalence was 3.09% (95% CI: 2.01–4.16%). For sleep disorders we evaluated 18 studies; none were population-based. The prevalence ranged from 0–1.6% for narcolepsy, 14.4–57.5% for restless legs syndrome, 2.22–3.2% for REM behavior disorder, and 7.14–58.1% for obstructive sleep apnea.Conclusion:This review suggests that seizure disorders and sleep disorders are common in MS, but highlights gaps in the epidemiological knowledge of these conditions in MS worldwide. Other than central-western Europe and North America, most regions are understudied.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Such varying results could be due to selection bias and differences in methods, definitions and diagnostic criteria (30, 34). For example, the accuracy of the MS diagnosis as well as the definition of epilepsy and its distinction toward non-epileptogenic, paroxysmal manifestations of MS, such as tonic spasm of the extremities, play a crucial role (36).…”

Section: Discussionmentioning

confidence: 99%

Patients With Epileptic Seizures and Multiple Sclerosis in a Multiple Sclerosis Center in Southern Germany Between 2003–2015

Schorner

Weissert

2019

Front. Neurol.

View full text Add to dashboard Cite

Background: So far, many studies have shown that the risk of developing seizures and epilepsy is higher among patients with multiple sclerosis (MS) than in the general population. However, the causal link between these two diseases is still unclear. In addition, it is not clearly understood whether and to what extent the manifestation of seizures and epilepsy in patients with MS affects the clinical course and the long-term prognosis of the disease. We aimed to retrospectively identify and describe patients with MS and with seizures and epilepsy which were seen at the Department of Neurology of the University of Regensburg in Germany between the years 2003–2015. Methods: With the help of the electronic documentation system of hospital admitted patients followed by scrutinizing medical records of patients with MS for evidence of seizures and epilepsy, we identified patients with MS and seizures or epilepsy. Results: We identified 22 individuals (1.74%) out of 1,267 patients with MS with seizures or epilepsy. 18 of these 22 individuals met criteria for epilepsy (1.42%). Nine MS patients (40.9%) suffered from relapsing-remitting MS (RRMS) whereas 11 MS patients (50.0%) showed a secondary progressive disease course (SPMS). Five of those (45.5%) converted from RRMS to SPMS before they acquired epilepsy. None of the identified patients with MS and seizures or epilepsy suffered from primary progressive MS (PPMS). Moreover, two MS patients (9.1%) had a history of seizures before MS onset. Seizures were of focal onset in 17 patients with MS (77.3%). Fourteen out of these 17 MS patients presented with focal to bilateral tonic-clonic seizures (82.4%). Five MS patients (22.7%) showed tonic clonic seizures of unknown onset. Status epilepticus was reported in three patients with MS (13%), for one patient the data was inconclusive. Conclusion: The occurrence of seizures and epilepsy was higher than in the general population, suggesting a causal relationship between both diseases. In most cases, seizures occurred after the first manifestation of MS. The high frequency of focal seizures supports the concept of cerebral lesions in patients with MS playing an important role in precipitation of seizures and epilepsy.

show abstract

“…One possible explanation is that MS lesions act as epileptogenic sites [88]. Generally, a small fraction (2.5%) of MS patients develop seizures [89]. The study of epilepsy in the elderly among MS patients is inconclusive, but clinicians should be aware of the risk of epilepsy in people with MS [88].…”

Section: Epilepsy In Degenerative Diseasesmentioning

confidence: 99%

Aging and Neurological Diseases

Kowalska¹,

Owecki²,

Prendecki³

et al. 2017

Senescence - Physiology or Pathology

View full text Add to dashboard Cite

Current knowledge indicates that the aging process starts with subclinical changes at the molecular level. These include the accumulation of mutations, telomere attrition, and epigenetic alterations leading to genomic instability. Such defects multiply exponentially over time, resembling a "snowball effect," and eventually leading to morphological and functional deterioration of the brain, including progressive neuronal loss, reduced levels of neurotransmitters, excessive inflammation, and disrupted integrity of vessels, followed by infarction and microbleeds. Additionally, the decreasing efficiency of DNA repair mechanisms increases the susceptibility to reactive oxygen species and spontaneous mutagenesis, resulting in age-related neoplasia. Moreover, the malnutrition and malabsorption seen commonly in the elderly may cause deficiency of vitamin B 12 and folic acid, both necessary for homocysteine metabolism, and lead to vascular damage. Altogether, these lead to brain damage in old age and greatly increase the risk of developing diseases of the central nervous system, such as stroke, epilepsy, Parkinson's disease, Alzheimer's disease, and other dementias.

show abstract

Prevalence of epilepsy in a case series of multiple sclerosis patients

Cited by 7 publications

References 15 publications

A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis

A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis

Patients With Epileptic Seizures and Multiple Sclerosis in a Multiple Sclerosis Center in Southern Germany Between 2003–2015

Aging and Neurological Diseases

Contact Info

Product

Resources

About