Anaplastic astrocytoma post radiotherapy of pineal germinoma

García-Navarro, Victor; Tena-Suck, Martha Lilia; Celis, Miguel Ángel; Vega, Rosalba; Rembao, Daniel; Salinas, Citlaltepetl

doi:10.1590/s0004-282x2009000400028

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Historically, RIGs have been clinically diagnosed as diffuse intrinsic pontine glioma (DIPG), 19 , 40 anaplastic astrocytoma (AA), 24 , 30 , 31 , 36–38 , 41 , 46 , 47 , 63 or GBM 22–25 , 28 , 29 , 34 , 38 , 39 , 41 , 42 , 45 , 46 , 48 , 50 based primarily on histological and/or radiographical characteristics. In very rare cases, the diagnosis of anaplastic ependymoma has also been reported.…”

Section: Discussionmentioning

confidence: 99%

Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

Whitehouse

Howlett

Federico

et al. 2021

Neuro-Oncology Advances

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Background Cranial radiation therapy is essential in treating many pediatric cancers, especially brain tumors, however its use comes with the risk of developing second malignancies. Cranial radiation-induced gliomas (RIGs) are aggressive high-grade tumors with a dismal prognosis, for which no standard therapy exists. A definitive molecular signature for RIGs has not yet been established. We sought to address this gap by performing a systematic review and meta-analysis of the molecular features of cranial RIGs. Methods A systematic review of the literature was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. English language articles and case reports referring to radiation-induced high-grade gliomas located in the human brain that included molecular analyses were identified, evaluated and data extracted for collation. Results Of 1727 records identified, 31 were eligible, containing 102 unique RIGs with molecular data. The most frequent genetic alterations in RIGs included PDGFRA or TP53 mutations, PDGFRA or CDK4 amplifications, and CDKN2A deletion, along with 1q gain, 1p loss and 13q loss. Of note, mutations in ACVR1, EGFR, H3F3A, HIST1H3B, HIST1H3C, IDH2, SMARCB1 or the TERT promoter were not observed. A comparative analysis revealed that RIGs are molecularly distinct from most other astrocytomas and gliomas and instead align most closely with the pedGBM_RTK1 subgroup of pediatric glioblastoma. Conclusions This comprehensive analysis highlights the major molecular features of RIGs, demonstrates their molecular distinction from many other astrocytomas and gliomas, and reveals potential genetic drivers and therapeutic targets for this currently fatal disease.

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Section: Discussionmentioning

confidence: 99%

Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

Whitehouse

Howlett

Federico

et al. 2021

Neuro-Oncology Advances

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Radiation-induced gliomas: a comprehensive review and meta-analysis

2016

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By conducting a systemic search of the PubMed database, we performed a comprehensive literature review to characterize secondary gliomas following radiotherapy treatment and to determine the most appropriate treatment strategy. Our analysis included 296 cases of radiation-induced gliomas. The primary lesion was characterized as a hematological malignancy in 104 cases (35.1 %), pituitary adenoma in 35 (11.8 %), craniopharyngioma in 19 (6.4 %), medulloblastoma in 38 (12.8 %), germ cell tumor in 13 (4.3 %), low-grade glioma in 28 (9.4 %), cancer/sarcoma in 12 (4.0 %), scalp region disease in 15 (5.0 %), meningioma/schwannoma in 13 (4.3 %), metastatic brain tumor in 5 (1.6 %), and other types (e.g., arteriovenous malformations and angiomas) in 14 (4.7 %). The average age of onset for primary lesions was 16.0 ± 15.8 years, and the average radiation dose delivered to the primary lesion was 37.6 ± 20.0 Gy. Secondary gliomas could be divided into grade I (1), grade II (32), grade III (88), and grade IV (173) tumors. The median overall survival for all glioma cases was 11 months (95 % confidence interval [CI], 9-12), with a 2-year survival rate of 20.2 %. On multivariate analysis, combined modality treatment and the latency period from the radiotherapy treatment to the glioma diagnosis were variables associated with the overall survival of patients with grade III/IV secondary gliomas. For patients treated with cranial radiotherapy, the risk of secondary glioma incidence warrants a longer follow-up period beyond the standard time frame typically designated for determining the risk of primary tumor relapse. Moreover, combination therapy is a potential treatment option for radiation-induced gliomas.

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Radiation-Induced Glioma

Yamanaka¹,

Hayano²

2015

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients With a Brain Tumor

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Anaplastic astrocytoma post radiotherapy of pineal germinoma

Cited by 3 publications

References 9 publications

Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

Radiation-induced gliomas: a comprehensive review and meta-analysis

Radiation-Induced Glioma

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