Radiation-induced gliomas: a comprehensive review and meta-analysis

Yamanaka, Ryuya; Hayano, Azusa; Kanayama, Tomohiko

doi:10.1007/s10143-016-0786-8

Cited by 67 publications

(71 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with neuroepithelial tumors treated with radiotherapy exhibited a non-significant positive trend with longer overall survival. Retrospective data supports the need for combined modality treatment in patients with secondary gliomas as reported [9]. The most effective treatment for radiation-induced meningiomas is surgical management, although radiosurgery could also be considered.…”

Section: Discussionsupporting

confidence: 57%

“…Spontaneous high-grade gliomas typically affect adults and are preferentially located in the cerebral hemispheres. However, the age of onset of radiation-induced gliomas is lower than that of spontaneous high grade gliomas [9]. In radiation-induced gliomas after pituitary irradiation, onset age is rather older (53 year) compared to radiation-induced gliomas in general (27 year), owing to the fact that the age of pituitary irradiation is rather older.…”

Section: Discussionmentioning

confidence: 99%

“…Radiation-induced intracranial tumors might occur within the brain, the dura mater, leptomeninges, optic sheath, vascular adventitia, or the choroid plexus within the central nervous system (CNS), although it is rare. Tumors such as meningiomas, sarcomas, and gliomas are the most frequently reported secondary neoplasms [7,8,9,10,11]. Cahan et al [12] established the diagnostic criteria for radiation-induced tumors.…”

Section: Introductionmentioning

confidence: 99%

“…These criteria were modified by Schrantz and Araoz [13] as follows: (1) the tumor must occur within the irradiated field; (2) the tumor must not be present prior to the radiotherapy; (3) a sufficient latency period must elapse between irradiation and tumor incidence; and (4) the radiation-induced tumor must be proven to be of a different histological type compared to the original neoplasm treated by radiotherapy. We have reported the results of a systematic review of radiation-induced gliomas, meningiomas, and sarcomas in 728 patients [9,10,11]. Of these, 104 (14.3%) patients were derived from pituitary irradiation, and this is one of the major etiologies of radiation-induced brain tumor.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review

Yamanaka

Abe

Toshihiko³

et al. 2017

Cancers

Self Cite

View full text Add to dashboard Cite

Pituitary adenomas are often treated with radiotherapy for the management of tumor progression or recurrence. Despite the improvement in cure rates, patients treated by radiotherapy are at risk of development of secondary malignancies. We conducted a comprehensive literature review of the secondary intracranial tumors that occurred following radiotherapy to pituitary adenomas to obtain clinicopathological characteristics. The analysis included 48 neuroepithelial tumors, 37 meningiomas, and 52 sarcomas which were published between 1959–2017, although data is missing regarding overall survival and type of irradiation in a significant proportion of the reports. The average onset age for the pituitary adenoma was 37.2 ± 14.4 years and the average latency period before the diagnosis of the secondary tumor was 15.2 ± 8.7 years. Radiotherapy was administered in pituitary adenomas at an average dose of 52.0 ± 19.5 Gy. The distribution of pituitary adenomas according to their function was prolactinoma in 10 (7.2%) cases, acromegaly in 37 (27.0%) cases, Cushing disease in 4 (2.9%) cases, PRL+GH in 1 (0.7%) case, non-functioning adenoma in 57 (41.6%) cases. Irradiation technique delivered was lateral opposing field in 23 (16.7%) cases, 3 or 4 field technique in 27 (19.6%) cases, rotation technique in 10 (7.2%) cases, radio surgery in 6 (4.3%) cases. Most of the glioma or sarcoma had been generated after lateral opposing field or 3/4 field technique. Fibrosarcomas were predominant before 1979 (p < 0.0001). The median overall survival time for all neuroepithelial tumors was 11 months (95% confidence intervals (CI), 3–14). Patients with gliomas treated with radiotherapy exhibited a non-significant positive trend with longer overall survival. The median overall survival time for sarcoma cases was 6 months (95% CI, 1.5–9). The median survival time in patients with radiation and/or chemotherapy for sarcomas exhibited a non-significant positive trend with longer overall survival. In patients treated with radiotherapy for pituitary adenomas, the risk of secondary tumor incidence warrants a longer follow up period. Moreover, radiation and/or chemotherapy should be considered in cases of secondary glioma or sarcoma following radiotherapy to the pituitary adenomas.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review

Yamanaka

Abe

Toshihiko³

et al. 2017

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…Within the brain, the most common secondary neoplasms arising after radiation therapy are meningiomas, gliomas, and sarcomas [11, 31]. Such radiation-induced gliomas are typically high-grade infiltrative astrocytomas associated with poor outcomes [11, 29, 31, 33]. …”

Section: Introductionmentioning

confidence: 99%

The genetic landscape of gliomas arising after therapeutic radiation

et al. 2018

View full text Add to dashboard Cite

Radiotherapy improves survival for common childhood cancers such as medulloblastoma, leukemia, and germ cell tumors. Unfortunately, long-term survivors suffer sequelae that can include secondary neoplasia. Gliomas are common secondary neoplasms after cranial or craniospinal radiation, most often manifesting as high-grade astrocytomas with poor clinical outcomes. Here, we performed genetic profiling on a cohort of 12 gliomas arising after therapeutic radiation to determine their molecular pathogenesis and assess for differences in genomic signature compared to their spontaneous counterparts. We identified a high frequency of TP53 mutations, CDK4 amplification or CDKN2A homozygous deletion, and amplifications or rearrangements involving receptor tyrosine kinase and Ras-Raf-MAP kinase pathway genes including PDGFRA, MET, BRAF, and RRAS2. Notably, all tumors lacked alterations in IDH1, IDH2, H3F3A, HIST1H3B, HIST1H3C, TERT (including promoter region), and PTEN, which genetically define the major subtypes of diffuse gliomas in children and adults. All gliomas in this cohort had very low somatic mutation burden (less than three somatic single nucleotide variants or small indels per Mb). The ten high-grade gliomas demonstrated markedly aneuploid genomes, with significantly increased quantity of intrachromosomal copy number breakpoints and focal amplifications/homozygous deletions compared to spontaneous high-grade gliomas, likely as a result of DNA double-strand breaks induced by gamma radiation. Together, these findings demonstrate a distinct molecular pathogenesis of secondary gliomas arising after radiation therapy and identify a genomic signature that may aid in differentiating these tumors from their spontaneous counterparts.

show abstract

The role of diffusion tensor imaging metrics in the discrimination between cerebellar medulloblastoma and brainstem glioma

Duc

2020

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Background Differentiation between cerebellar medulloblastoma and brainstem glioma is necessary for certain clinical circumstances. We aimed to evaluate the function of diffusion tensor imaging (DTI) metrics in the differentiation between cerebellar medulloblastomas and brainstem gliomas in children. Procedure The institutional review board approved this prospective study. Brain magnetic resonance imaging (MRI), including DTI, was assessed in 40 patients, who were divided into two groups: a medulloblastoma group (group 1, n = 25) and a brainstem glioma group (group 2, n = 15). The Mann‐Whitney U test was utilized to compare tumoral fractional anisotropy (FA) and diffusivity (MD) values and tumor‐to‐parenchyma ratios for these values (rFA and rMD, respectively) between the two groups. Receiver‐operating characteristic (ROC) curve analysis and the Youden index were exploited to calculate the cutoff value, along with the area under the curve (AUC), sensitivity, and specificity. Results The FA value for medulloblastomas was significantly higher than that for brainstem gliomas (P < 0.05). In contrast, the MD and rMD values for medulloblastoma were significantly lower than those for brainstem gliomas (P < 0.05). A cutoff MD value of 0.97 was identified as the most effective factor for the differential diagnosis between medulloblastomas and brainstem gliomas, which reached a sensitivity of 96%, a specificity of 100%, and an AUC of 99.5%. Conclusion DTI metrics play a significant role in the differentiation between medulloblastoma and brainstem glioma in pediatric patients.

show abstract

Radiation-induced gliomas: a comprehensive review and meta-analysis

Cited by 67 publications

References 165 publications

Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review

Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review

The genetic landscape of gliomas arising after therapeutic radiation

The role of diffusion tensor imaging metrics in the discrimination between cerebellar medulloblastoma and brainstem glioma

Contact Info

Product

Resources

About