Solitary fibrous tumor with intracranial invasion

Welling, Leonardo C.; Lynch, José Carlos; Ferreira, Leandro Alcy Sales; Corrêa, Juliano; Sapunaru, Mendel; Cortezzi, Wladimir; Schulz, Renata

doi:10.1590/s0004-282x2009000400026

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…A few of the orbital SFT cases reported have displayed malignant histological features, defined by hypercellularity, pleomorphism, increased tumor size (≥5 cm), mitotic counts >4 per 10 high-power fields, and necrosis. 29 , 38 , 44 – 47 Immunohistochemically, the expression of CD34 may be lost in tumors that undergo malignant transformation in cases of orbital SFTs. 40 , 45 However, these pathologic factors do not always correlate with the clinical behavior of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Orbital solitary fibrous tumor: a clinicopathologic study from a Chinese tertiary hospital with a literature review

Shen¹,

Li²,

Feng

et al. 2018

CMAR

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PurposeTo report the clinical features, imaging manifestations, histopathology, and immunohistochemical features of several cases of orbital solitary fibrous tumors (SFTs) in a Chinese tertiary hospital, and to undertake a literature review of this rare disease.MethodsA non-comparative retrospective review of clinical presentations, imaging manifestations, histopathology, and immunohistochemical features as well as the management and disease outcomes of patients with orbital SFT was conducted along with a review of orbital SFT cases in the literature.ResultsThis study includes two male and two female patients, with an average age of 53 years. Common presentations among these patients included a palpable subcutaneous mass, swelling of the eyelid, proptosis, diplopia, and vision disturbance. Three patients (cases 2–4) underwent imaging scans. All patients had complete surgical excisions and the tissue was subjected to pathological analysis. One patient (Case 4) experienced a recurrence with malignant transformation and received a re-excision surgery and postoperative radiotherapy. All patients remain alive and well after a minimum follow-up of 12 months (range 12–34 months).ConclusionDespite its rare occurrence, we suggest that the possibility of orbital SFTs needs to be considered when a painless, slowly growing orbital mass is identified. Typical characteristic magnetic resonance imaging features of orbital SFTs are iso- or hypointense signals on T1 and T2-weighted images, with marked enhancement. A positive cluster of differentiation 34 (CD34) staining is an important diagnostic clue favoring SFT. Some orbital SFTs are infiltrating, aggressive, or recur with malignant transformation. Therefore, regular long-term follow-up after complete excision is mandatory.

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Section: Discussionmentioning

confidence: 99%

Orbital solitary fibrous tumor: a clinicopathologic study from a Chinese tertiary hospital with a literature review

Shen¹,

Li²,

Feng

et al. 2018

CMAR

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“…SFTs in the CNS are most often dura-based neoplasms and can occur in any location, with reports in the supratentorium,[666771] parenchyma,[13] sella,[23] ventricle,[616376975] cerebellopontine angle,[5] orbit/paranasal sinuses,[7880] tentorium,[65] posterior fossa meninges,[2764] along cranial nerves V[48] and VI,[77] at the foramen of Monroi,[35] and in the infratemporal fossa. [6268] There is a tendency to manifest in the posterior fossa and spine as well as along spinal nerve rootlets.…”

Section: Epidemiologymentioning

confidence: 99%

"Hitting all the right markers to save a life" Solitary fibrous tumors of the central nervous system: Case series and review of the literature

Kasper

Boruchow²,

Lam³

et al. 2012

Surg Neurol Int

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Background:Solitary fibrous tumors (SFTs) of the central nervous system are uncommon. Their biological features remain largely unknown; hence, the clinical management and prognosis is often challenging due to the lack of comprehensive data. For this reason, we present two cases of large SFTs to illustrate a comprehensive review.Methods:This was a retrospective analysis of two patients: a 65-year-old male with a left parietooccipital lesion and a 70-year-old female with a right parietal convexity mass.Results:Gross total resection was performed in the male patient with no recurrence 30 months after resection. The second patient received stereotactic radiosurgery for what was initially thought to be a parafalcine meningioma; however, continued growth 1 year later prompted an open resection, with pathology indicative of an SFT. The tumor recurred the following year requiring repeat resection. Unfortunately, due to the aggressive nature of the lesion, the patient eventually succumbed to tumor burden a year later.Conclusion:Based on the literature review, the sometimes observed aggressive growth pattern, and also, the potential for malignant transformation, we recommend complete resection of SFTs with close sequential follow-up.

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“…Intra-orbital OSFT is extremely rare, and cranio-orbital OSFT is even rarer. [9][10][11] There are a few related reports in many literatures. In recent years,…”

Section: Introductionmentioning

confidence: 99%

Factors for Postoperative Recurrence of Orbital Solitary Fibrous Tumor: An Analysis of Long-Term Clinical Follow-Up Results From a Chinese Tertiary Hospital

Yang

Liu

Qiu

et al. 2020

Preprint

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BackgroundThis study analyzed the clinical features, imaging manifestations, histopathology, immunohistochemistry, and surgical approaches of the orbital solitary fibrous tumor (OSFT), as well as the factors for postoperative recurrence of such disease.MethodsThe clinical data of 16 patients with OSFT treated in our center from 2003 to 2020 were analyzed retrospectively, and the clinical symptoms, treatment methods, and follow-up results were recorded.ResultsOf the 16 patients, 8 were females (50.0%) and 8 were males (50.0%); the average age of treatment was 37 ± 7 years and the median follow-up time was 74 (8, 228) months. Sixteen patients with OSFT underwent a total of 29 operations, of which 12 were transorbital approach operations and 17 were transfronto-orbital approach operations. Ten patients (10/16, 62.5%) had recurrence. The recurrence rate of transorbital approach operations was 83.3% (10/12), and the recurrence rate of transfronto-orbital approach operations was 17.6% (3/17). No patients had treatment-related complications.ConclusionsThe main pathological feature of OSFT is a benign tumor. OSFT has a tendency to grow toward the cranio-orbital junction. The postoperative recurrence rate of OSFT is relatively high, so complete tumor resection is very important for prognosis. Inappropriate surgical approaches can lead to incomplete removal of the tumor and cause recurrence. Choosing the correct operation approach according to the position of the OSFT in the orbit and complete removal of the dura mater and bone affected by the tumor is crucial for the prognosis. Nevertheless, regular long-term follow-up after complete resection is necessary.

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Solitary fibrous tumor with intracranial invasion

Cited by 8 publications

References 13 publications

Orbital solitary fibrous tumor: a clinicopathologic study from a Chinese tertiary hospital with a literature review

Orbital solitary fibrous tumor: a clinicopathologic study from a Chinese tertiary hospital with a literature review

"Hitting all the right markers to save a life" Solitary fibrous tumors of the central nervous system: Case series and review of the literature

Factors for Postoperative Recurrence of Orbital Solitary Fibrous Tumor: An Analysis of Long-Term Clinical Follow-Up Results From a Chinese Tertiary Hospital

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