Factors for Postoperative Recurrence of Orbital Solitary Fibrous Tumor: An Analysis of Long-Term Clinical Follow-Up Results From a Chinese Tertiary Hospital

Abstract

BackgroundThis study analyzed the clinical features, imaging manifestations, histopathology, immunohistochemistry, and surgical approaches of the orbital solitary fibrous tumor (OSFT), as well as the factors for postoperative recurrence of such disease.MethodsThe clinical data of 16 patients with OSFT treated in our center from 2003 to 2020 were analyzed retrospectively, and the clinical symptoms, treatment methods, and follow-up results were recorded.ResultsOf the 16 patients, 8 were females (50.0%) and 8 were males (50.0%); the average age of treatment was 37 ± 7 years and the median follow-up time was 74 (8, 228) months. Sixteen patients with OSFT underwent a total of 29 operations, of which 12 were transorbital approach operations and 17 were transfronto-orbital approach operations. Ten patients (10/16, 62.5%) had recurrence. The recurrence rate of transorbital approach operations was 83.3% (10/12), and the recurrence rate of transfronto-orbital approach operations was 17.6% (3/17). No patients had treatment-related complications.ConclusionsThe main pathological feature of OSFT is a benign tumor. OSFT has a tendency to grow toward the cranio-orbital junction. The postoperative recurrence rate of OSFT is relatively high, so complete tumor resection is very important for prognosis. Inappropriate surgical approaches can lead to incomplete removal of the tumor and cause recurrence. Choosing the correct operation approach according to the position of the OSFT in the orbit and complete removal of the dura mater and bone affected by the tumor is crucial for the prognosis. Nevertheless, regular long-term follow-up after complete resection is necessary.

Orbital Solitary Fibrous Tumor: Four Case Reports—Clinical and Histopathological Features

“…The fourth case is a patient with a history of craniopharyngioma surgery in pediatric age; the tumor was resected due to a possible recurrence [ 22 ].…”

Clinicopathological Characteristics of Three Cases with Recurrent Orbital Solitary Fibrous Tumors: A Retrospective Study and Literature Review

“…In the present research, clinical, imaging, and pathological features of 3 patients with recurrent orbital SFT were retrospectively compared. We also used the PubMed database to search for recurrent orbital SFT, and 21 related literatures were selected to explore their clinical and pathological features [3,4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”

“…The masses of three cases in the current study were elliptical, all of which were behind the eyeball and con ned by the orbital wall. Yang et al pointed out that although a tumor is mainly benign, it may involve the orbital bone and occasionally penetrate the orbital wall and invade the intracranial structure [23]. During the second surgery on Case #1 and Case #2, surgeons found an adhesion between the masses and the orbital bone.…”