Co-existing fibrous dysplasia and meningothelial meningioma

Alves, Raphael Vicente; Souza, Anderson Rodrigo; Silva, Alessandra; Cardim, Vera Lúcia Nocchi; Godoy, Roberto

doi:10.1590/s0004-282x2009000400025

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…They commonly demonstrate osteoblastic activity with robust hyperostosis surrounding a central lesion [2]. Meningiomas can also display mixed osteoblastic and osteoclastic activity, or more rarely an osteolytic response [3]. Although sphenoid involvement might be secondary to an extension of a dural meningioma, in our case, the clinical history and tumor configuration on MRI favor a primary intraosseous meningioma with dural extension [4,5].…”

Section: Discussionmentioning

confidence: 66%

“…The clinical and radiologic characteristics of meningioma can be confused with those of fibrous dysplasia [1,2,3,[6][7][8]. Fibrous dysplasia is a congenital, progressive anomaly of bones characterized by the replacement of normal bone structure by fibro-osseous tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Positive staining of cells with EMA on immunohistochemistry further aids in the diagnosis. Although it is possible for fibrous dysplasia and intraosseous meningioma to concomitantly occur [3], it is more likely that the previous surgical specimens only sampled the peripheral hyperostotic fibrotic changes, omitting the meningioma component. This resulted in a delay in the final diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Intraosseous Meningioma Masquerading as Fibrous Dysplasia

Shaftel¹,

Alameddine²,

Oh³

et al. 2016

Diagn Pathol Open

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Intraosseous Meningioma Masquerading as Fibrous Dysplasia

Shaftel¹,

Alameddine²,

Oh³

et al. 2016

Diagn Pathol Open

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Coexistence of meningioma and craniofacial fibrous dysplasia: a case series of clinicopathological study and literature review

Song,

2024

Orphanet J Rare Dis

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Background The co-existence of meningioma and craniofacial fibrous dysplasia (CFD) is rare. Due to the similar radiological characteristics, it is challenging to differentiate such co-existence from solitary hyperostotic meningioma resulting in a dilemma of prompt diagnosis and appropriate intervention. Method We conducted a retrospective review of the data from 21 patients with concomitant meningioma and CFD who were treated at Beijing Tiantan Hospital from 2003 to 2021. We summarized their clinicopathological features and performed a comprehensive literature review. Additionally, we tested the characteristic pathogenic variants in exon 8 and 9 of GNAS gene and the expression of corresponding α-subunit of the stimulatory G protein (Gαs) related to CFD to explore the potential interactions between these two diseases. Results The cohort comprised 4 men and 17 women (mean age, 45.14 years). CFD most commonly involved the sphenoid bone (n = 10) and meningiomas were predominantly located at the skull base (n = 12). Surgical treatment was performed in 4 CFD lesions and 14 meningiomas. Simpson grade I-II resection was achieved in 12 out of the 14 resected meningiomas and almost all of them were classified as WHO I grade (n = 13). The mean follow-up duration was 56.89 months and recurrence was noticed in 2 cases. Genetic study was conducted in 7 tumor specimens and immunohistochemistry was accomplished in 8 samples showing that though GNAS variant was not detected, Gαs protein were positively expressed in different degrees. Conclusions We presented an uncommon case series of co-diagnosed meningioma and CFD and provided a detailed description of its clinicopathological features, treatment strategy and prognosis. Although a definite causative relationship had not been established, possible genetic or environmental interplay between these two diseases could not be excluded. It was challenging to initiate prompt diagnosis and appropriate treatment for concomitant meningioma and CFD because of its similar radiological manifestations to meningioma with reactive hyperostosis. Personalized and multi-disciplinary management strategies should be adopted for the co-existence of meningioma and CFD.

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Abstracts of the 2010 Meeting of the International Neuro-Ophthalmology Society, Lyon, France

2010

Neuro-Ophthalmology

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Co-existing fibrous dysplasia and meningothelial meningioma

Cited by 3 publications

References 7 publications

Intraosseous Meningioma Masquerading as Fibrous Dysplasia

Intraosseous Meningioma Masquerading as Fibrous Dysplasia

Coexistence of meningioma and craniofacial fibrous dysplasia: a case series of clinicopathological study and literature review

Abstracts of the 2010 Meeting of the International Neuro-Ophthalmology Society, Lyon, France

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