Auditory processing disorders in twins with perisylvian polymicrogyria

Boscariol, Mirela; Garcia, Vera Lúcia; Guimarães, Catarina Abraão; Hage, Simone Rocha de Vasconcellos; Montenegro, Maria Augusta; Cendes, Fernando; Guerreiro, Marilisa M.

doi:10.1590/s0004-282x2009000300023

Cited by 10 publications

(21 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deficits in processing rapidly-presented verbal and non-verbal acoustic information have been shown in many individuals with dyslexia and other forms of developmental language impairment [12, 15, 39, 64-67]. Moreover, it has been suggested that rapid auditory processing skills underlie in part higher cognitive processes such as phonological processing (which plays an essential role in reading acquisition) in both dyslexic and non-dyslexic populations [68-70].…”

Section: Discussionmentioning

confidence: 99%

Knockdown of the Candidate Dyslexia Susceptibility Gene Homolog Dyx1c1 in Rodents: Effects on Auditory Processing, Visual Attention, and Cortical and Thalamic Anatomy

Szalkowski¹,

Booker

Truong³

et al. 2013

Dev Neurosci

View full text Add to dashboard Cite

The current study investigated the behavioral and neuroanatomical effects of embryonic knockdown of the candidate dyslexia susceptibility gene (CDSG) homolog Dyx1c1 through RNA interference (RNAi) in rats. Specifically, we examined long-term effects on visual attention abilities in male rats, in addition to assessing rapid and complex auditory processing abilities in male and, for the first time, female rats. Our results replicated prior evidence of complex acoustic processing deficits in Dyx1c1 male rats and revealed new evidence of comparable deficits in Dyx1c1 female rats. Moreover, we found new evidence that knocking down Dyx1c1 produced orthogonal impairments in visual attention in the male subgroup. Stereological analyses of male brains from prior RNAi studies revealed that, despite consistent visible evidence of disruptions of neuronal migration (i.e., heterotopia), knockdown of Dyx1c1 did not significantly alter the cortical volume, hippocampal volume, or midsagittal area of the corpus callosum (measured in a separate cohort of like-treated Dyx1c1 male rats). Dyx1c1 transfection did, however, lead to significant changes in medial geniculate nucleus (MGN) anatomy, with a significant shift to smaller MGN neurons in Dyx1c1-transfected animals. Combined results provide important information about the impact of Dyx1c1 on behavioral functions that parallel domains known to be affected in language-impaired populations as well as information about widespread changes to the brain following early disruption of this CDSG.

show abstract

Section: Discussionmentioning

confidence: 99%

Knockdown of the Candidate Dyslexia Susceptibility Gene Homolog Dyx1c1 in Rodents: Effects on Auditory Processing, Visual Attention, and Cortical and Thalamic Anatomy

Szalkowski¹,

Booker

Truong³

et al. 2013

Dev Neurosci

View full text Add to dashboard Cite

show abstract

“…Etiologies ranging from trauma to neurotoxic substances and neurologic disease or insult may cause dysfunction in the central auditory nervous system (CANS), resulting in a CAPD (American Academy of Audiology, 2010). Similarly, in recent years, evidence of atypical neuromorphology in children with CAPD has been presented (e.g., Boscariol et al, 2009Boscariol et al, , 2010Boscariol et al, , 2011Fig. Musiek et al (1985;Musiek and Gollegly, 1988) postulated three primary underlying etiologies of CAPD in children: (1) neuromorphologic disorders, including atypical left/right anatomic asymmetries in planum temporale, ectopic areas, and polymicrogyri (65-70%); (2) neuromaturational delay (25-30%); and (3) neurologic disorder, disease, or insult (<5%).…”

Section: Introductionmentioning

confidence: 90%

Central auditory processing disorders in children and adults

Bellis

2015

The Human Auditory System - Fundamental Organization and Clinical Disorders

View full text Add to dashboard Cite

“…Neocortical migrational anomalies have been associated with learning, language, and other cognitive deficits in humans (Galaburda et al ., 1994; Casanova et al ., 2004; Hage et al ., 2006; Boscariol et al ., 2009). Studies from our lab have shown that rodents with cortical malformations exhibit deficits in rapid auditory processing abilities, which are similar to those observed in humans with language impairment (Peiffer et al ., 2004a; Threlkeld et al ., 2006; 2007).…”

Section: Introductionmentioning

confidence: 99%

Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1

Szalkowski

Hinman

Threlkeld

et al. 2010

Genes, Brain and Behavior

View full text Add to dashboard Cite

Disruptions in the development of the neocortex are associated with cognitive deficits in humans and other mammals. Several genes contribute to neocortical development, and research into the behavioral phenotype associated with specific gene manipulations is advancing rapidly. Findings include evidence that variants in the human gene DYX1C1 may be associated with an increased risk of developmental dyslexia. Concurrent research has shown that the rat homolog for this gene modulates critical parameters of early cortical development, including neuronal migration. Moreover, recent studies have shown auditory processing and spatial learning deficits in rats following in utero transfection of an RNA interference (RNAi) vector of the rat homolog Dyx1c1 gene. The current study examined the effects of in utero RNAi of Dyx1c1 on working memory performance in Sprague-Dawley rats. This task was chosen based on the evidence of short-term memory deficits in dyslexic populations, as well as more recent evidence of an association between memory deficits and DYX1C1 anomalies in humans. Working memory performance was assessed using a novel match-to-place radial water maze task that allows the evaluation of memory for a single brief (∼4-10 seconds) swim to a new goal location each day. A 10-min retention interval was used, followed by a test trial. Histology revealed migrational abnormalities and laminar disruption in Dyx1c1 RNAi-treated rats. Dyx1c1 RNAi-treated rats exhibited a subtle, but significant and persistent impairment in working memory as compared to Shams. These results provide further support for the role of Dyx1c1 in neuronal migration and working memory.

show abstract

Auditory processing disorders in twins with perisylvian polymicrogyria

Cited by 10 publications

References 4 publications

Knockdown of the Candidate Dyslexia Susceptibility Gene Homolog Dyx1c1 in Rodents: Effects on Auditory Processing, Visual Attention, and Cortical and Thalamic Anatomy

Knockdown of the Candidate Dyslexia Susceptibility Gene Homolog Dyx1c1 in Rodents: Effects on Auditory Processing, Visual Attention, and Cortical and Thalamic Anatomy

Central auditory processing disorders in children and adults

Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1

Contact Info

Product

Resources

About