Extremely delayed cerebral vasospasm after subarachnoid hemorrhage

Cecon, Angelo Daros; Figueiredo, Eberval Gadelha; Bor-Seng-Shu, Edson; Scaff, Milberto; Teixeira, Manoel Jacobsen

doi:10.1590/s0004-282x2008000400024

Cited by 7 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, IL-1, which has been implicated in the pathogenesis of cerebral vasospasm, also represents a strong stimulus for CRP synthesis [1][2][3][4][5]. So, elevated concentrations of CRP may well be associated with an increased possibility of developing cerebral vasospasm and subsequently a DIND [1,3,[22][23][24][25]28].…”

Section: Discussionmentioning

confidence: 99%

Predicting vasospasm after aneurismal subarachnoid hemorrhage with C reactive protein levels

Romero¹,

Ducati²,

Zanini³

et al. 2013

Health

View full text Add to dashboard Cite

Aim: The interest of inflammatory marker increased in the last years, even in preventing clinical outcome after subarachnoid hemorrhage (SAH). Our objective was to study the relationships between C-reactive protein levels and clinical outcome and the development of cerebral vasospasm after aneurismal SAH. Methods: One hundred adult patients with aneurismal SAH were prospectively evaluated. Glasgow Coma Scale (GCS) score, Hunt and Hess grade, Fisher grade, CT scans, digital subtraction angiography studies, transcranial doppler (TCD) and daily neurological examinations were recorded. Serial serum CRP measurements were obtained on daily between admission and 10th days. Glasgow Outcome Scale (GOS) and the modified Rankin Scale (mRS) were used to predict outcome. Results: A progressive increase in the CRP levels from the admission to the 3rd postictal day was observed, followed by a slow decrease until the 9th day. Hemodynamic changes in TCD were associated with higher serum CRP levels. Patients with lower GCS scores presented with increased CRP levels. Patients with higher Hunt and Hess grades on admission developed significantly higher CRP serum levels. Patients with higher admission Fisher grades showed increased levels of CRP. A statistically significant inverse correlation was established in our series between CRP serum levels and GOS and mRS scores on discharge and CRP levels. Conclusion: Increased CRP levels were strongly associated with poor clinical outcome. CRP levels can predict cerebral vasospasm and delayed ischemic deficits with higher statistic significance. There are relationships between hemodynamic chances in TCD and higher CRP levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Predicting vasospasm after aneurismal subarachnoid hemorrhage with C reactive protein levels

Romero¹,

Ducati²,

Zanini³

et al. 2013

Health

View full text Add to dashboard Cite

show abstract

“…Additionally, IL-1, which has been implicated in the pathogenesis of cerebral vasospasm, also provides a strong stimulus for CRP synthesis 1,[3][4][5] . Therefore, elevated CRP concentrations may well be associated with an increased possibility of developing cerebral vasospasm and subsequently a delayed ischemic neurological deficit (DIND) 1,3,[24][25][26][27][28][29] .…”

Section: Discussionmentioning

confidence: 99%

Serum C-reactive protein levels predict neurological outcome after aneurysmal subarachnoid hemorrhage

Romero

Bertolini²,

Figueiredo

et al. 2012

Arq. Neuro-Psiquiatr.

Self Cite

View full text Add to dashboard Cite

OBJECTIVES: Our aim was to evaluate the relationship between serum C-reactive protein (CRP) levels and the neurological prognosis and development of vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). METHODS: Eighty-two adult patients with aSAH diagnoses were prospectively evaluated. Glasgow Coma Scale (GCS) score, Hunt and Hess grade, Fisher grade, cranial CT scans, digital subtraction angiography studies and daily neurological examinations were recorded. Serial serum CRP measurements were obtained daily between admission and the tenth day. Glasgow Outcome Scale (GOS) and the modified Rankin Scale (mRS) were used to assess the prognosis. RESULTS: Serum CRP levels were related to severity of aSAH. Patients with lower GCS scores and higher Hunt and Hess and Fisher grades presented statistically significant higher serum CRP levels. Patients with higher serum CRP levels had a less favorable prognosis. CONCLUSIONS: Increased serum CRP levels were strongly associated with worse clinical prognosis in this study.

show abstract

“…Accumulating evidence suggested that the inflammatory response is crucial in the development of DCVS. Several morphological studies (4–6) have demonstrated that there are a large number of inflammatory cells infiltrating the spastic vessel wall and its surrounding tissues in the development of DCVS. The study by Handa et al (7) has also indicated that the elevated expression of intercellular adhesion molecule-1 (ICAM-1) may contribute to the development of DCVS.…”

Section: Introductionmentioning

confidence: 99%

Potential role of poly (ADP‑ribose) polymerase in delayed cerebral vasospasm following subarachnoid hemorrhage in rats

Fan

Liu

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

Poly (ADP-ribose) polymerase (PARP) serves a key role in several neurological disorders, however, the specific role of PARP in delayed cerebral vasospasm (DCVS) following subarachnoid hemorrhage (SAH) remains unclear. The present study was conducted to clarify the possible mechanism of PARP in DCVS with the treatment of 3-aminobenzamide (3-AB), a PARP inhibitor. In the preliminary experiment, an internal carotid artery puncture SAH model, a cisterna magna double injection SAH model and prechiasmatic cistern single injection SAH model were compared with respect to mortality and neurobehavioral test results. The prechiasmatic cistern single injection SAH model was chosen to induce DCVS in the formal experiment. In the formal experiment, a total of 96 Sprague Dawley rats were randomly allocated into the sham group, the SAH group and the SAH+3-AB group and then each group was further subdivided into days 3, 5, 7 and 14 post-SAH subgroups (n=8 for each subgroup). The prechiasmatic cistern single injection SAH model was established to induce DCVS. Neurobehavioral testing and HE staining were conducted to evaluate the degree of cerebral vasospasm. PARP activity was assessed by ELISA and immunohistochemistry. An electrophoretic mobility shift assay was used to detect nuclear factor (NF)-κB DNA-binding activity. The expression of monocyte chemotactic protein 1 (MCP-1) and C-reactive protein (CRP) were measured by western blotting. Cerebral vasospasm occurred following SAH and became most severe on around day 7 post-SAH. NF-κB activity, PARP activity, the expression of MCP-1 and CRP exhibited a similar time course to cerebral vasospasm. Treatment with 3-AB alleviated the degree of cerebral vasospasm. NF-κB activity, PARP activity and the expression of MCP-1 and CRP were also suppressed by 3-AB treatment. In conclusion, PARP may serve an important role in regulating the inflammatory response and ultimately contribute to DCVS. Therefore 3-AB may be a potential therapeutic agent for DCVS.

show abstract

Extremely delayed cerebral vasospasm after subarachnoid hemorrhage

Cited by 7 publications

References 14 publications

Predicting vasospasm after aneurismal subarachnoid hemorrhage with C reactive protein levels

Predicting vasospasm after aneurismal subarachnoid hemorrhage with C reactive protein levels

Serum C-reactive protein levels predict neurological outcome after aneurysmal subarachnoid hemorrhage

Potential role of poly (ADP‑ribose) polymerase in delayed cerebral vasospasm following subarachnoid hemorrhage in rats

Contact Info

Product

Resources

About