Serum C-reactive protein levels predict neurological outcome after aneurysmal subarachnoid hemorrhage

Romero, Flávio Ramalho; Bertolini, Eduardo de Freitas; Figueiredo, Eberval Gadelha; Teixeira, Manoel Jacobsen

doi:10.1590/s0004-282x2012000300009

Cited by 24 publications

(32 citation statements)

References 28 publications

(27 reference statements)

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“…Kubo et al (2008) additionally demonstrated that elevated hsCRP, at day 0 and day 7, was associated with delayed ischemic neurological deficits. Romero et al (2012) demonstrated that elevated blood levels of CRP were associated with less favorable prognosis on discharge and that CRP blood levels were related to severity of SAH. Frontera et al (2012) concurred showing that CRP blood levels were significantly higher in poorer grade patients over time and correlated with severity of SAH on admission.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers as outcome predictors in subarachnoid hemorrhage – a systematic review

Hong¹,

Tosun²,

Kurland³

et al. 2014

Biomarkers

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Context Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome. Objective The aim of this review was to summarize biomarkers of SAH associated with outcome. Methods An electronic database query was completed, including an additional review of reference lists to include all potential human studies. Results A total of 298 articles were identified; 112 were reviewed; 55 studies were included. Conclusion This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.

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Section: Discussionmentioning

confidence: 99%

Biomarkers as outcome predictors in subarachnoid hemorrhage – a systematic review

Hong¹,

Tosun²,

Kurland³

et al. 2014

Biomarkers

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“…Inflammation is an important mechanism underlying hemorrhagic brain injury (Badjatia et al., ; Ma, Zhou, Yan, Qu, & Bu, ). Some inflammation‐related biomarkers have shown high prognostic value for aSAH (Kim et al., ; Pan, Yan, Hassan, Fang, & Chen, ; Romero, Bertolini Ede, Figueiredo, & Teixeira, ). Galectin‐3 (Gal‐3) belongs to the galectin family and is characterized by a conserved sequence within the carbohydrate recognition domain that has an affinity for β‐galactoside residues (Dumic, Dabelic, & Flögel, ; Nangia‐Makker, Nakahara, Hogan, & Raz, ; Pricci et al., ).…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of plasma galectin‐3 levels after aneurysmal subarachnoid hemorrhage

Liu

Zhao

et al. 2016

Brain and Behavior

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BackgroundInflammatory responses are correlated with secondary brain injury after aneurysmal subarachnoid hemorrhage (aSAH). Galectin‐3 (Gal‐3) is a novel biomarker reflecting inflammation status, and its elevated circulating levels are associated with poor prognosis of some inflammatory diseases. The aim of this study was to evaluate the relationship between Gal‐3 plasma levels and prognosis in a group of aSAH patients.Materials and MethodsWe assessed plasma Gal‐3 levels in 120 patients and 120 healthy individuals. 6‐month clinical outcomes included mortality and unfavorable outcome (Glasgow Outcome Scale score of 1–3). Associations of plasma Gal‐3 levels with clinical outcomes were investigated using multivariate analysis.ResultsPatients showed significantly higher Gal‐3 levels as compared to controls. Circulating Gal‐3 was significantly and independently associated with 6‐month clinical outcomes in the logistic regression analysis. Moreover, we observed a significant correlation between circulating Gal‐3 and World Federation of Neurological Surgeons scores and modified Fisher scores. Furthermore, Gal‐3 possessed high area under receiver operating characteristic curve for prognostic assessment.ConclusionOur findings indicate the associations between Gal‐3 levels and the severity and poor prognosis following aSAH. This suggests the possible role of Gal‐3 in the prognostic prediction after aSAH.

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“…Cerebral vasospasm is a prolonged, sometimes severe narrowing of cerebral arteries following a subarachnoid hemorrhage (SAH), consisting the major cause of morbidity in this disease [1][2][3][4] . Angiographic vasospasm is common after rupture of an aneurysm, with overall incidence of 50% to 90%, but only 20% to 30% of patients develop clinical vasospasm, as a result of ischemia and delayed ischemic neurological deficits [5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein and vasospasm after aneurysmal subarachnoid hemorrhage1

Romero

Catâneo

2014

Acta Cir. Bras.

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PURPOSE: To evaluate the relationship between C reactive protein levels and clinical and radiological parameters with delayed ischemic neurological deficits and outcome after aneurysmal subarachnoid hemorrhage. METHODS:One hundred adult patients with aneurismal SAH were prospectively evaluated. Besides the baseline characteristics, daily C-reactive protein levels were prospectively measured until day 10 after subarachnoid hemorrhage. The primary end point was outcome assessed by Glasgow Outcome Scale, the secondary was the occurrence of delayed ischemic neurological deficits (DINDs). RESULTS:A progressive increase in the CRP levels from the admission to 3rd postictal day was observed, followed by a slow decrease until the 9th day. Hemodynamic changes in TCD were associated with higher serum CRP levels. Patients with lower GCS scores presented with increased CRP levels. Patients with higher Hunt and Hess grades on admission developed significantly higher CRP serum levels. Patients with higher admission Fisher grades showed increased levels of CRP. A statistically significant inverse correlation was established in our series between CRP serum levels and GOS on discharge and CRP levels. CONCLUSIONS:Higher C-reactive protein serum levels are associated with worse clinical outcome and the occurrence of delayed ischemic neurological deficits. Because C-reactive protein levels were significantly elevated in the early phase, they might be a useful parameter to monitor.

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Serum C-reactive protein levels predict neurological outcome after aneurysmal subarachnoid hemorrhage

Cited by 24 publications

References 28 publications

Biomarkers as outcome predictors in subarachnoid hemorrhage – a systematic review

Biomarkers as outcome predictors in subarachnoid hemorrhage – a systematic review

Prognostic value of plasma galectin‐3 levels after aneurysmal subarachnoid hemorrhage

C-reactive protein and vasospasm after aneurysmal subarachnoid hemorrhage1

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