Epileptic seizures and EEG features in juvenile systemic lupus erythematosus

Abstract

-Introduction: Juvenile systemic lupus erythematosus is more incident in female affecting different systems including the central nervous system. The aim of this study was to check the incidence of seizures and electroencephalographic features in these patients. Method: It was analyzed all patients with juvenile systemic lupus erythematosus referred to the Pequeno Príncipe Hospital in Curitiba, PR, Brazil, in the year of 2007. The patients were submitted to EEG and subdivided into two groups according to the presence or absence of epileptic seizures. Mann-Whitney statistical test was used. Results: Forty-nine cases were included, there were 73.45% female, with an age between 3 and 28 years (m=17.00 years; s=5.01 years). Seizures (13/26.50%) were the most frequent manifestation followed by headache (13/26.50%) and ischemic stroke (6/12.25%). Cerebral vasculites were the most frequent alteration in neuroimage. The abnormalities of EEG were characterized by asymmetry of the electric cerebral activity, diffuse disorganized background activity, focal epileptiform discharges in the right central-temporal region, generalized paroxysmal of 3 Hz spike-waves, and bursts of theta-delta slowness activity in the right parietal-occiptal region. The statistic analysis showed no significantly difference between age of onset of symptoms and the risk of seizures (p 0.675) as well as between time of the disease and the risk of seizures (p 0.436). Conclusion: Neurologic manifestations, in special epileptic seizures, are frequent in systemic lupus erythematosus. Age of onset of symptoms and the time of disease did not increase the risk of epileptic seizures in this disease.KEy WoRdS: juvenile systemic lupus erythematosus, epileptic seizures, neurologic manifestation.crises epilépticas e características do EEG em pacientes com lúpus eritematoso sistêmico juvenil Resumo -Introdução: Lupus eritematoso sistêmico juvenil é doença mais freqüente no sexo feminino afetando múltiplos sistemas, incluindo o sistema nervoso central. o objetivo deste estudo foi avaliar a incidência de crises epilépticas e de alterações eletrencefalográficas nestes pacientes. Método: Foram avaliados todos os pacientes com lupus eritematoso sistêmico juvenil encaminhados para o Hospital Pequeno Príncipe em Curitiba, PR, Brasil, no ano de 2007. os pacientes foram submetidos a EEG e subdivididos em 2 grupos conforme a presença ou não de crises epilépticas. A análise foi realizada através do teste estatístico de Mann-Whitney. Resultados: 49 casos foram incluídos, sendo 73,45% do sexo feminino, com idade variando entre 3 e 28 anos (m=17,00 anos; s=5,01 anos). Crises epilépticas (13/26,50%) foram a manifestação neurológica mais freqüente, seguidas de cefaléia (13/26,50%) e acidente vascular cerebral isquêmico (6/12,25%). Vasculite cerebral foi a alteração de imagem mais freqüente. As alterações no EEG foram caracterizadas por assimetria da atividade elétrica cerebral, desorganização difusa da atividade de base, descargas epileptiformes na região centro-tempora...

Super refractory status epilepticus of neuropsychiatric systemic lupus erythematosis: a rare case

“…Anormal olan hastalarda da sıklıkla asimetrik serebral aktivite, yaygın organizasyon bozukluğu gibi nonspesifik bulgular izlenmektedir. [12] Anti-fosfolipid antikoru pozitif olan hastaların EEG'lerinin patolojik olma ihtimali daha fazladır. [13] Anti-fosfolipid antikoru pozitif olan olgumuzun EEG monitörizasyonunda her iki frontotemporal bölgelerde keskin-yavaş dalgalardan oluşan sürekli epileptiform deşarjlar izlendi.…”

Electroencephalography Findings in Autoimmune and Neuroinflammation-Related Epilepsies

“…[72][73][74] Systemic lupus erythematosus (SLE) is an autoimmune condition that affects multiple body systems, including the central nervous system in up to 75% of patients. 75 Seizures occur in 15 to 20% of patients with SLE. 76 Both focal and generalized seizure types have been reported, with focal seizures occurring occasionally in association with other SLE-related complications, such as strokes.…”

“…76 Other findings have been nonspecific including focal slowing, background disorganization, generalized epileptiform abnormalities, and interictal focal epileptiform abnormalities. 75 Specific EEG features in the other systemic autoimmune conditions have not been identified outside of case reports.…”

Headache Research and Medical Practice in Brazil: An Historical Overview

“…A number of the early articles on headache disorders were published by Farias da Silva and coworkers in the scientific journal Neurobiologia (Recife), which is one of the oldest journals in the area of neurology in Latin America, founded in 1943 by Ulysses Pernambucano. Another important journal containing articles on headache written by Brazilians is Arquivos de Neuropsiquiatria , which was founded in 1945 …”