Inclusion body myositis and HIV infection

Freitas, Marcos R. G. de; Neves, Marco Antônio Orsini; Nascimento, Osvaldo Jm; Mello, Mariana Pimentel de; Botelho, John P.; Chimelli, Leila

doi:10.1590/s0004-282x2008000300033

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…Interestingly, despite the relationship described between sIBM and serum positivity for antibodies to hepatitis C virus [ 36 – 38 ], none of the patients in this series had positive serology for hepatitis C. In another Brazilian study with 30 patients with sIBM, one patient had positive serology for hepatitis C and two for HIV [ 29 ]. Freitas et al [ 39 ] reported a coexistence of sIBM with HIV infection, and Cupler et al [ 40 ] reported two cases with this association. In our study, only one patient had viral seropositive for HTLV-I, which was also reported in an American patient [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis

Camargo

Carvalho

Shinjo

et al. 2018

BioMed Research International

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Sporadic inclusion body myositis (sIBM) is considered the most common acquired myopathy aged over 50 years. The disease is characterized by a particular process of muscle degeneration characterized by abnormal deposit of protein aggregates in association with inflammation. The aim of this study was to present clinical and muscle histopathological findings, including immunostaining for LC3B, p62, α-synuclein, and TDP-43, in 18 patients with sIBM. The disease predominated in males (61%) and European descendants, with onset of clinical manifestations around 59 years old. The most common symptoms were muscle weakness, falls, dysphagia, and weight loss. Hypertension was the main comorbidity. Most of the cases presented with paresis predominantly proximal in lower limbs and distal in upper limbs. Immunosuppressive treatment showed to be not effective. Muscle histological findings included dystrophic changes, endomysial inflammation, increased lysosomal activity, and presence of rimmed vacuoles and of beta-amyloid accumulation, in addition to high frequency of mitochondrial changes. There was increased expression of LC3B, p62, α-synuclein, and TDP-43 in muscle biopsies. The sIBM has characteristic clinical and histological findings, and the use of degeneration and autophagic markers can be useful for the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis

Camargo

Carvalho

Shinjo

et al. 2018

BioMed Research International

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“…Another category of viruses, retroviruses, which include HIV and human T-lymphotropic virus 1 (HTLV-1), has been related to development of IIM in case reports [24,27]. Thirteen patients were reported to develop polymyositis after HIV infection, with an average time of 4.3 years from viral infection to disease onset [26] and four patients who developed IBM after exposure to HIV were also studied [25].…”

Section: Viruses and Idiopathic Inflammatory Myopathymentioning

confidence: 99%

State of the art

Gan¹,

Miller²

2011

Current Opinion in Rheumatology

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“…Furthermore, after the introduction of HAART, the patient's quality of life increased. However, chronic complications have arisen in some patients, leading to many motor and sensory disabilities: for instance, mononeuropathies, inflammatory demyelinating polyneuropathies, motor neuron disease, polymyositis, myopathies, diffuse infiltrative lymphocytosis syndrome, mononeuritis multiplex and other clinical manifestations [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Motor Neuron Disease and Acquired Axonal Neuropathy Association in HIV Infection: Case Report and Update

Orsini¹,

Freitas²,

Silva³

et al. 2012

CHR

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Abstract:Background: A possible viral etiology has been documented in the genesis of motor neuron disorders and acquired peripheral neuropathies, mainly due to the vulnerability of peripheral nerves and the anterior horn to certain viruses. In recent years, several reports show association of HIV infection with Amyotrophic Lateral SclerosisSyndrome, Motor Neuron Diseases and peripheral neuropathies.Objective: To report a case of an association between Motor Neuron Disease and Acquired Axonal neuropathy in HIV infection, and describe the findings of neurological examination, cerebrospinal fluid, neuroimaging and electrophysiology. Methods:The patient underwent neurological examination. General medical examinations were performed, including, specific neuromuscular tests, analysis of cerebrospinal fluid, muscle biopsy and imaging studies. Results and Discussion:The initial clinical presentation of our case was marked by cramps and fasciculations with posterior distal paresis and atrophy in the left arm. We found electromyography tracings with deficits in the anterior horn of the spinal cord and peripheral nerves. Dysphagia and release of primitive reflexes were also identified. At the same time, the patient was informed to be HIV positive with high viral load. He received antiretroviral therapy, with load control but with no clinical remission. Conclusion:Motor Neuron disorders and peripheral neuropathy may occur in association with HIV infection. However, a causal relationship remains uncertain. It is noteworthy that the antiretroviral regimen may be implicated in some cases.

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Inclusion body myositis and HIV infection

Cited by 7 publications

References 16 publications

Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis

Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis

State of the art

Motor Neuron Disease and Acquired Axonal Neuropathy Association in HIV Infection: Case Report and Update

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