State of the art

Gan, Lu; Miller, Frederick W.

doi:10.1097/bor.0b013e32834b5457

Cited by 35 publications

(14 citation statements)

References 80 publications

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“…In follow-up examinations, we found that myositis can persist for a long time, even when the patient responds well to steroid and immunosuppressive therapy. Because viral agents can cause idiopathic inflammatory myopathies, infection with the chikungunya virus might also trigger this type of condition in the long term (38) . Inflammatory involvement secondary to infection is a subject that has been discussed for some time, and the chikungunya virus has been associated with such involvement (34) .…”

Section: Discussionmentioning

confidence: 99%

Ultrasound of ankles in the diagnosis of complications of chikungunya fever

et al. 2017

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ObjectiveTo describe the main ultrasound findings of chikungunya fever in the ankle.Materials and MethodsThis was a cross-sectional observational study involving 52 patients referred to the Hospital Universitário Pedro Ernesto and presenting with clinical and biochemical evidence of chikungunya fever. The examinations were performed by a radiologist with more than 20 years of experience in ultrasound.ResultsThe predominant gender was female (in 88.5%), and the mean age was 58.4 years. The majority (61.5%) of the patients came from the northern part of the city of Rio de Janeiro, and 46.2% were using corticosteroids to treat inflammatory symptoms. The most common alterations observed by ultrasound were joint effusion (in 69.2%), tenosynovitis (in 59.6%), cellulitis (in 46.2%), Kager's fat pad thickening (in 29.9%), myositis (of the soleus or flexor hallucis longus muscle) (in 17.3%), retrocalcaneal bursitis (in 5.8%), tendon ruptures (in 3.8%), and increased vascular flow on power Doppler (in 3.8%).ConclusionSigns of synovitis and tenosynovitis were the main ultrasound findings in a predominantly female population with a mean age of 58.4 years. Further studies are needed in order to define the role of ultrasound in the follow-up of such patients.

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Section: Discussionmentioning

confidence: 99%

Ultrasound of ankles in the diagnosis of complications of chikungunya fever

et al. 2017

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“…This is a substantial limitation given that empirical approaches emphasize the importance of appropriate evidence being applicable to the specific patient or problem at hand (Gillam & Siriwardena, 2014). Nevertheless, failing to fully engage with clients who intend to use wearables as part of their treatment might lead to those clients seeking help elsewhere, or worse still, not at all (Coffey & Coffey, 2016). If nothing else, the use of wearables as an adjunct to therapy may potentially help through expectancy effects and increased engagement.…”

Section: Discussionmentioning

confidence: 99%

“…Practice with calming technologies might therefore help to increase self-efficacy, reduce aversive interpretations of somatic arousal (Meuret, Wilhelm, & Roth, 2004), or even lead to lasting physiological changes (e.g., improved baroreflex function; Lehrer et al, 2003). Relaxation techniques already have an established place in the treatment of anxiety disorders (Manzoni, Pagnini, Castelnuovo, & Molinari, 2008), but given the rapid development and commercialization of wearables, little knowledge has been generated thus far about whether they could facilitate this approach to treatment (Coffey & Coffey, 2016). Nonetheless, despite the lack of existing evidence, numerous online reviews and opinion pieces offer enthusiastic endorsement for the use of these devices in improving well-being and addressing clinical disorders such as anxiety.…”

Section: Introductionmentioning

confidence: 99%

Wearable devices as adjuncts in the treatment of anxiety‐related symptoms: A narrative review of five device modalities and implications for clinical practice.

Hunkin

King

Zajac

2019

Clinical Psychology: Science and Practice

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Anxiety disorders are a major public health problem, and a range of wearable technological devices for addressing the somatic symptoms of anxiety are increasingly available. This narrative review summarizes five distinct modalities underlying wearable devices and investigates clinical implications for managing clients using such devices. The literature suggests potential benefits of heart rate variability (HRV) biofeedback devices, while other modalities (aided meditation, false physiological feedback, electrodermal biofeedback, and respiration biofeedback) are less supported. High‐quality research on the efficacy of such devices is also lacking, particularly in clinical populations. Wearables could offer potential benefits, but may be contraindicated in some cases. Collaborative use of clinical evaluation tools, such as the American Psychiatric Association's application evaluation model, can aid in shared decision‐making about device use.

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“…Furthermore, arbovirus infections associated with skeletal muscle involvement and often subsequent neurological complications pose a particularly escalating threat in children (32–35). Myositis disorders in humans are thought to be multifactorial diseases involving genetic factors and environmental triggers such as virus infections, yet these disorders remain poorly characterized with few treatment options available (83–88). Thus, there is an urgent need to define better animal models to study virus-induced myositis.…”

Section: Discussionmentioning

confidence: 99%

SHP-1–Dependent Macrophage Differentiation Exacerbates Virus-Induced Myositis

Watson

Schneider

Massa

2015

The Journal of Immunology

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Virus-induced myositis is an emerging global affliction that remains poorly characterized with few treatment options. Moreover, muscle-tropic viruses often spread to the central nervous system causing dramatically increased morbidity. Therefore, there is an urgent need to explore genetic factors involved in this class of human disease. This report investigates critical innate immune pathways affecting murine virus-induced myositis. Of particular importance, the key immune regulator SHP-1, which normally suppresses macrophage-mediated inflammation, is a major factor in promoting clinical disease in muscle. We show that Theiler’s murine encephalomyelitis virus infection of skeletal myofibers induces inflammation and subsequent dystrophic calcification with loss of ambulation in wild type mice. Surprisingly, although similar extensive myofiber infection and inflammation is observed in SHP-1-deficient (SHP-1−/−) mice, these mice neither accumulate dead calcified myofibers nor lose ambulation. Macrophages were the predominant effector cells infiltrating WT and SHP-1−/− muscle, and an increased infiltration of immature monocytes/macrophages correlated with absence of clinical disease in SHP-1−/− mice, while mature M1-like macrophages corresponded with increased myofiber degeneration in WT mice. Furthermore, blocking SHP-1 activation in WT macrophages blocked virus-induced myofiber degeneration, and pharmacologic ablation of macrophages inhibited muscle calcification in TMEV-infected WT animals. These data suggest that following TMEV infection of muscle, SHP-1 promotes M1 differentiation of infiltrating macrophages, and these inflammatory macrophages are likely involved in damaging muscle fibers. These findings reveal a pathological role for SHP-1 in promoting inflammatory macrophage differentiation and myofiber damage in virus-infected skeletal muscle, thus identifying SHP-1 and M1 macrophages as essential mediators of virus-induced myopathy.

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State of the art

Cited by 35 publications

References 80 publications

Ultrasound of ankles in the diagnosis of complications of chikungunya fever

Ultrasound of ankles in the diagnosis of complications of chikungunya fever

Wearable devices as adjuncts in the treatment of anxiety‐related symptoms: A narrative review of five device modalities and implications for clinical practice.

SHP-1–Dependent Macrophage Differentiation Exacerbates Virus-Induced Myositis

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