Clinical outcome of neonatal bacterial meningitis according to birth weight

Krebs, Vera Lúcia Jornada; Costa, Gleise Aparecida Moraes

doi:10.1590/s0004-282x2007000700011

Cited by 24 publications

(24 citation statements)

References 16 publications

(24 reference statements)

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“…En cambio, para la tardía se asocian factores relacionados con terapia intensiva como procedimientos invasivos y técnicas neuroquirúrgicas (2,3,8,9) . La frecuencia de aislamiento del patógeno es variable, 14% hasta 78%, y usualmente se describen Streptococcus del grupo B (GBS), Escherichia coli y Listeria monocytogenes (2,3,(10)(11)(12) .…”

Section: Introductionunclassified

Meningitis neonatal en un hospital general de Lima, Perú, 2008 al 2015

Lewis

Schweig

Guillén–Pinto

et al. 2017

Rev Peru Med Exp Salud Publica

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NEONATAL MENINGITIS IN A GENERAL HOSPITAL IN LIMA, PERU, 2008 TO 2015 ABSTRACTAiming at describing the incidence, clinical characteristics and factors associated with neonatal meningitis (NM), a case series study was conducted from 2008 to 2015, where 53 neonates, 10 with early onset NM and 43 with late onset were included. An incidence of 1.5 per thousand live births and a lethality of 3.8% were found. The associated factors were peripartum fever, urinary tract infection and chorioamnionitis (P < 0.05). Frequent symptoms were fever (84.9%), hypotonia (77.4%) and hypoactivity (73.6%). In the cerebrospinal fluid (CSF), the cases of early NM presented a median of 330 leukocytes/µl and 29 mg/dl of glucose, and the cases of late NM presented 170 leukocytes/µl and 32 mg/dl of glucose. The most common bacteria were Listeria monocytogenes (16.9%) and negative coagulase staphylococcus (11.3%). In conclusion, the incidence was high compared to other studies and the associated factors were the expected.

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Section: Introductionunclassified

Meningitis neonatal en un hospital general de Lima, Perú, 2008 al 2015

Lewis

Schweig

Guillén–Pinto

et al. 2017

Rev Peru Med Exp Salud Publica

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“…The authors pointed out that meningitis frequently occurs in the absence of bacteremia and, for that reason, lumbar puncture is an important part of the diagnostic investigation in cases of suspected sepsis, since it may be the only positive test 11 . Another study conducted in São Paulo on 87 newborns with meningitis diagnosed by cytological and biochemical alterations reported that 39% of the cases had positive CSF cultures and only 17% showed positive blood cultures 24 . Hematological tests have not been shown to be useful for differentiating between the agents and are unspecific in relation to infection and meningitis diagnosis 22 .…”

Section: Discussionmentioning

confidence: 98%

“…In agreement with data in the literature, complications such as ventriculitis, hydrocephaly and abscesses were more frequent in Gram-negative meningitis. Ventriculitis may occur in 40 to 90% of the cases, particularly when bacteria persist in the CSF, while hydrocephaly is usually associated with ventriculitis and hemorrhage 24 . The frequency of abscesses was rather high (15%) in comparison with the rates of 1% to 3.4% reported in the literature 24,26 .…”

Section: Discussionmentioning

confidence: 99%

“…Ventriculitis may occur in 40 to 90% of the cases, particularly when bacteria persist in the CSF, while hydrocephaly is usually associated with ventriculitis and hemorrhage 24 . The frequency of abscesses was rather high (15%) in comparison with the rates of 1% to 3.4% reported in the literature 24,26 . Abscesses may develop slowly, and they are not always easily seen, which hinders diagnosis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neonatal meningitis according to the microbiological diagnosis: a decade of experience in a tertiary center

Bentlin¹,

Ferreira²,

Rugolo³

et al. 2010

Arq. Neuro-Psiquiatr.

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The aim of this study was to evaluate the incidence of and mortality due to meningitis and compare data according to microbiological diagnosis. This was a ten-year retrospective study conducted at a neonatal intensive care unit (NICU). Newborns with meningitis confirmed by positive CSF culture were included; those with congenital infection or malformations that made lumbar puncture impossible were excluded. The variables investigated were birth weight, gestational and postnatal age, procedures, hematological and CSF parameters, and complications. Parametric and non-parametric tests were used (statistical value p<0.05). The incidence of meningitis was 0.6% and mortality was 27%. Of the 22 cases, 59% involved Gram-negative bacteria; 36% Gram-positive and 5% fungi. The groups did not differ in relation to birth weight, gestational and postnatal age, procedures or hematological and CSF parameters. Sepsis, convulsions and deaths were frequent in both groups, without statistical difference. Gram-negative cases showed abscesses and higher frequency of ventriculitis and hydrocephaly. Meningitis was infrequent, but presented high mortality and frequent complications. Key words: meningitis, newborn, central nervous system, sepsis.Meningite neonatal de acordo com diagnóstico microbiológico: uma década de experiência em centro terciário RESUMO O objetivo do estudo foi avaliar incidência e mortalidade da meningite e comparar dados de acordo com o diagnóstico microbiológico. Estudo retrospectivo, de 10 anos, em UTI Neonatal. Incluídos RNs com meningite confirmada por cultura de líquor positiva; RN com infecção congênita ou malformações que impedem punção lombar foram excluídos. Variáveis: peso ao nascimento, idades gestacional e pós natal, procedimentos, parâmetros hematológicos e liquóricos, complicações. Testes paramétricos e não paramétricos foram utilizados (valor estatístico p<0,05). A incidência de meningite foi de 0,6% e mortalidade de 27%. Dos 22 casos, 59% foram por bactérias Gram-negativas; 36% por bactérias Grampositivas e 5% por fungos. Grupos não diferiram quanto ao peso ao nascimento, idades gestacional e pós-natal, procedimentos e por parâmetros hematológicos e liquóricos. Sepse, convulsões e óbitos foram frequentes e não diferiram entre os grupos. Gramnegativos causaram abscessos e mais frequentemente ventriculite e hidrocefalia. Meningite não foi freqüente, mas apresentou alta mortalidade e complicações. Palavras-chave: meningite, recém-nascido, sistema nervoso central, sepse.

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“…(Volpe, 2008a(Volpe, ,2008b. Inefficiency in the neonates alternative complement pathway compromises their defense against encapsulated bacteria (Krebs et al, 2007) T-cell defense and mediation of B-cell activity also are compromised. Finally, deficient migration and phagocytosis by neutrophils contribute to neonatal vulnerability to pathogens of even low virulence.…”

Section: Introductionmentioning

confidence: 99%