Polimorfismo da apolipoproteína e nos familiares em primeiro grau de pacientes com doença de Alzheimer familial ou esporádica

Cação, João de Castilho; Souza, Dorotéia Rossi Silva; Tognola, Waldir Antônio; Godoy, Maria de Fátima Guerreiro; Pinhel, Marcela Augusta de Souza

doi:10.1590/s0004-282x2007000200020

Cited by 3 publications

(1 citation statement)

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“…This may be explained by the higher life expectancy of women creating a bias in the proportion of women in the elderly population, associated with longer survival of AD women compared to men. 20 …”

Section: Discussionmentioning

confidence: 99%

Cognitive and renal dysfunction in the elderly

Carmo¹,

Pires²,

Gorzoni³

et al. 2013

Dement. neuropsychol.

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Cognitive impairment has been associated with several diseases and organic disturbances but few studies have explored the relationship between renal function and cognition.OBJECTIVEThe aim of this study was to compare the renal function of elderly patients with and without Alzheimer's disease, and to identify potential associated comorbidities, as well as the presence of microalbuminuria.METHODSA group of 60 patients with dementia syndrome and probable Alzheimer's disease, and 20 patients without dementias, followed at the Geriatric outpatient unit of the Santa Casa de São Paulo Hospital, were selected for this study.RESULTSThe results showed that the groups studied differed in terms of age, gender and Mini-Mental State Exam score, but no statistical difference was found for the presence of comorbidities (diabetes mellitus, dyslipidemia and systemic arterial hypertension). A significant difference in estimated creatinine clearance was observed between the two groups, with the Alzheimer's disease patients presenting significantly lower values than control subjects. Similarly, analysis of a portion of the two groups for the presence of microalbuminuria revealed a statistically significant difference between the two groups.CONCLUSIONThe study conclusions were that patients with Alzheimer's disease had lower glomerular filtration and a higher incidence of microalbuminuria, yet without having more classic risk factors for Alzheimer's disease such as systemic arterial hypertension, diabetes mellitus or dyslipidemia.

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Section: Discussionmentioning

confidence: 99%