Association of cytokines, neurological disability, and disease duration in HAM/TSP patients

Abstract

-Objective: To identify clinical and immunological markers associated with HTLV-I associated m y e l o p a t h y / t ropical spastic paraparesis (HAM/TSP). Method: 237 HTLV-I infected individuals were clinically assessed. They were classified according to the Expanded Disability Status Scale (EDSS) and Osame's Motor Disability Score (OMDS). Cytokine levels were determined in HTLV-I seropositive individuals. R e s u l t s : 37 patients had HAM/TSP. There was a correlation between the degrees of disability assessed by both scales. T h e re was also a correlation between the duration of HAM/TSP and the severity of disability assessed by either EDSS or OMDS. Higher levels of IFN-γ w e re detected in unstimulated peripheral blood mononuclear cells (PBMC) from HAM/TSP patients as compared with HTLV-I carriers. Conclusion: This study shows the validity of the neurological scales to classify the degree of neurological disability in HTLV-I carriers and suggests a pro g ressive behavior of HAM/TSP. This study also shows that IFN-γ in PBMC supernatants are markers of HAM/TSP. KEY WORDS: human T-lymphotropic virus 1, nervous system diseases, cytokines, neurological disability. PA L AV R A S -C H AVE: v í rus 1 linfotrópico T humano, doenças do sistema nervoso, citocinas, incapacidade neurológica. Associação de citocinas, incapacidade neurológica e duração da doença em pacientes com mielopatia associada ao HTLV-I/paraparesia espástica tropical (MAH/PET) RESUMO -O b j e t i v o: Identificar marc a d o res clínicos e imunológicos associados com a mielopatia associada ao HTLV-I / p a r a p a resia espástica tropical (MAH/PET

An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta-analysis

“…In HAM/TSP disease, PSMB8 in associated with PSMB8, JAK2, STAT1, IFI35, IRF1, GBP2, IFITM1, HLA-B, ISG20, GBP5, SOCS1, BST2, IFNG, and UBE2L6 activate the Interferon Signaling pathway and Cytokine Signaling in Immune system. The importance of cytokines especially IFN-γ for the HAM ⁄TSP pathogenesis were previously reported [50, 51].…”

Pain in tropical spastic paraparesis/HTLV-I associated myelopathy patients

“…It is known that in TSP/HAM the key pathological event is an inflammatory demyelinating lesion in the spinal cord consequent upon immune mechanisms involving cytokines, such as IFN-γ and TNF-α 39,40 , and this may be expressed mainly in the beginning of the neurological symptoms, but also along the disease, declining, however, with the disease duration 41 . It is also clear that in inflammatory nociceptive and neuropathic pain, cytokines such as TNF-α, IL-1, IL-6 and IL-8 [16][17][18][19] are mainly implicated.…”

Avaliação De Conhecimento Em Proteção Radiológica Na Comunidade Acadêmica: Um Estudo Transversal

“…Dentre os aspectos imunopatológicos da HAM/TSP, a exacerbação inflamatória e intensa ativação da resposta imune com elevada carga proviral refletem um perfil desregulado e propício à disseminação do HTLV-1. Na infecção pelo vírus, as proteínas virais TAX e HBZ modulam a expressão de genes do hospedeiro em células infectadas causando proliferação espontânea de linfócitos T CD4+, aumento da produção de citocinas pro-inflamatórias (IFN-γ e TNF-α), além de desencadear um estado de imortalização nestas células, refletindo em um estado inflamatório crônico, persistente e desregulado (ASQUITH et al, 2007;MUNIZ et al, 2006;ROBEK;RATNER et al, 1999). Logo, supõe-se que a presença da infecção pelo HTLV-1 pode prejudicar o funcionamento normal dos linfócitos T regulatórios (Treg).…”