Neurological manifestations of dengue infection: clinical characteristics and cerebrospinal fluid analysis

Abstract

Introduction. Neurological manifestation is considered a rare complication of dengue infection. Encephalitis, myelitis, Guillain Barré syndrome (GBS), cranial nerve palsies have been recognized as clinical consequences of dengue infection. Objective. To determine and correlate the neuro l o g ical and cere b rospinal fluid (CSF) characteristics of patients with dengue infection and to evaluate the use of two dengue enzyme-linked immunosorbent assays (ELISA) kits in the CSF. Method. We report 17 IgM seropositive patients for dengue who presented diff e rent neurological manifestations in the course of the acute infection. With these manifestations, patients were divided in four groups: headache, encephalitis, myelitis and GBS. Total and diff e rential cytology count, protein and glucose levels and ELISA for IgM and IgG dengue antibodies were examined in the CSF samples from all 17 patients. In six of them (myelitis and GBS patients), the albumin and IgG concentrations were determined in serum and CSF. CSF and serum from Brazilian and German patients with other neurological diseases were used as controls for IgG and IgM dengue tests. Result. We had seven patients with encephalitis, two with myelitis, four with GBS and four with headache associated with acute dengue infection. The CSF was nor

Post‐Dengue New Daily Persistent Headache

“…In 97.6% of the patients, with confirmed dengue, headache was reported, which usually lasts 2 to 7 days. Soares reported that CSF was normal in all patients with headache only and in 42.8% of the subjects with encephalitis when she evaluated 17 patients with neurological manifestations and IgM seropositive for dengue, in the course of the acute infection.…”