Manifestações neurológicas em crianças e adolecentes infectados e expostos ao HIV-1

Rocha, Cristiane; Gouvea, Aïda de Fátima Barbosa; Machado, Daisy Maria; Cunegundes, Kelly Simone Almeida; Beltrão, Suênia Cordeiro de Vasconcelos; Bononi, Fabiana; Succi, Regina Célia

doi:10.1590/s0004-282x2005000500020

Cited by 13 publications

(16 citation statements)

References 10 publications

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“…The negative environmental factors and other adverse comorbidities are equally important in this context (16). Seropositive children living in foster care had a worse performance on the fine motor PDMS-II scale, when compared to children living in family homes, which confirms the influence of the external environment on motor acquisition (35).…”

Section: Resultsmentioning

confidence: 71%

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Motor performance of HIV-positive children

et al. 2016

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Introduction: Evidence indicates that HIV-positive children have a lower motor performance compared to uninfected children. The analysis of the factors that determine these changes is very important for the implementation of rehabilitation strategies. Objective: To analyze the motor development of seropositive children and compare it to the performance of healthy children with normal neuropsycomotor development. Materials and Methods: Eight children were evaluated, aged between four and six years, divided into two groups: Group I (n = 4) composed of HIV-positive children without any secondary disease and Group II (n = 4) composed of healthy children, matched to Group I by sex and age. The Peabody Developmental Motor Scales (PDMS-2) for gross motor function and fine motor function were used to evaluate motor performance. Results: In both groups, most of the children presented an average or above average motor performance, according to normal data of PDMS-2. The analysis indicated no inter-group differences in the gross scores (p > 0,05, Mann-Whitney test) or motor quotients (p> 0.05, Mann-Whitney test). However, intra-group analysis indicated a marginally significant difference between motor quotients (p = 0,07, Wilcoxon test), with higher fine motor quotient in both

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Section: Resultsmentioning

confidence: 71%

“…A study performed with 173 children with HIV indicated the occurrence of some type of neurological impairment in 67% of the sample, with NPMD along with language delay, intellectual disability, pyramidal syndrome and hyporeflexia observed more frequently (16).…”

Section: Methodsmentioning

confidence: 99%

Motor performance of HIV-positive children

et al. 2016

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“…Dysarthria might have not been observed, once central nervous system alterations may only be evident after years of the HIV infection, not being observed at early stages. The presence of microcephaly, cognitive impairment, signs of pyramidal tract dysfunction, mood and behavioral disorders, and complications due to the use of antiretroviral therapy are common (9) .…”

Section: Introductionmentioning

confidence: 99%

Análises perceptivo-auditiva e acústica das vozes de crianças infectadas pelo HIV

Pereira

Rodrigues

Silvério

et al. 2017

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RESUMO Objetivo Comparar parâmetros vocais e acústicos de crianças infectadas e não infectadas pelo HIV (Vírus da Imunodeficiência Humana). Método Amostras vocais foram submetidas às análises perceptivo-auditiva e acústica. Foram analisadas amostras da vogal sustentada /ε/ e da fala encadeada de 74 crianças entre seis e 12 anos incompletos, divididas em dois grupos: 37 crianças infectadas pelo HIV (GHIV) e 37 crianças não infectadas pelo HIV (Grupo Controle=GC), pareadas por idade e gênero, e sem avaliação vocal prévia; todas as crianças eram pré-púberes, pelos Critérios de Tanner (MS, 2014). As crianças tiveram suas vozes gravadas e analisadas pelo programa VoxMetria 5.1, no período de 2014 a 2015. A análise perceptivo-auditiva avaliou o grau geral da qualidade vocal e foi realizada utilizando-se a escala analógico-visual (EAV) de 100 pontos, transformada em escala numérica de 4 pontos (0- ausência de desvio e 4- desvio intenso). A avaliação acústica constou da análise da distribuição da amostra vocal no Diagrama de Desvio Fonatório (DDF). A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa em Seres Humanos, sob o número 122.746. Resultados Na análise perceptivo-auditiva, a maioria das crianças de ambos os grupos foi avaliada como apresentando vozes sem desvio, grau 0 na escala numérica. Na análise acústica, não houve diferença entre os grupos na distribuição das amostras no DDF, com a maioria das amostras na área de normalidade, no primeiro quadrante, com distribuição de densidade ampliada e forma vertical. Conclusão Crianças infectadas pelo HIV apresentaram vozes semelhantes às de crianças sem a doença, tanto do ponto de vista auditivo quanto acústico.

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“…The action of HIV in the organism of a child ranges from a decrease in immunity due to the destruction of CD4 cells, which makes an individual susceptible to opportunistic infection, to neurological alterations caused by the neurotropism of HIV in a developing brain (6) . The most common neurological alterations are retarded neuropsychomotor development, delayed language acquisition, mental deficiency, hyporeflexia, and pyramidal syndrome (7) . The incidence of these disorders ranges from 30% to 90% in pediatric patients, considering age, intensity and immunological involvement as important factors.…”

Section: Introductionmentioning

confidence: 99%