2005
DOI: 10.1590/s0004-282x2005000400009
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Electrophysiologic assessment of regeneration in rat sciatic nerve repair using suture, fibrin glue or a combination of both techniques

Abstract: -We evaluated the repair of seccioned rat sciatic nerve by the comparison of electro p h y s i o l o gic parameters. The repair was effected with suture (group A), fibrin glue (group B) or a combination of both techniques (group C). The amplitude, latency and conduction velocity of the motor and nerve action potentials were assessed before the nerve section and at reoperation after 24 weeks. There was no diff e rence between the groups when the nerve action potential was evaluated. Rats of group B presented be… Show more

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Cited by 34 publications
(28 citation statements)
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“…The study was approved by the Ethics Committee of the University of São Paulo Medical School and all procedures followed national animal welfare guidelines. The data used were part of a previously reported study comparing the nerve regeneration outcome from sciatic nerve repair with suture, fibrin glue or a combination of both techniques 7 . For this study, the data were not separated according to procedure, but rather were treated as independent data points, allowing analysis of correlations between nerve regeneration parameters obtained with the use of three different techniques.…”
Section: Methodsmentioning
confidence: 99%
“…The study was approved by the Ethics Committee of the University of São Paulo Medical School and all procedures followed national animal welfare guidelines. The data used were part of a previously reported study comparing the nerve regeneration outcome from sciatic nerve repair with suture, fibrin glue or a combination of both techniques 7 . For this study, the data were not separated according to procedure, but rather were treated as independent data points, allowing analysis of correlations between nerve regeneration parameters obtained with the use of three different techniques.…”
Section: Methodsmentioning
confidence: 99%
“…The clot formed by the sealant is a physiological compound found in tissue repair, and this makes it different from other types of sealants which present toxicity and high fibrin formation [17]. Fibrin sealant presents its own biological properties, being versatile in different clinical settings, including in combination with conventional suture techniques [16,18].…”
Section: Introductionmentioning
confidence: 99%
“…La aparición de los geles de fibrina ha supuesto una revolución en la sutura nerviosa puesto que carecen de efecto inhibitorio sobre la regeneración axonal (36), alcanzando resultados similares en menos tiempo (37,38), hasta el punto de que consiguen menor fibrosis que las suturas, mejor regeneración axonal (39) y mayor velocidad de conducción y amplitud de onda en los estudios neurofisiológicos (40). Por estas razones utilizamos la sutura epineural con nylon 10-0 de aproximación, junto con el sellado de la anastomosis mediante gel de fibrina en todos los casos.…”
Section: Discussionunclassified