Vasculite cerebral e doença de Basedow-Graves: relato de dois casos

Rocha, Maria Sheila Guimarães; Brucki, Sônia Maria Dozzi; Ferraz, Ana Cláudia

doi:10.1590/s0004-282x2001000600021

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…18 We considered central nervous system vasculitis an etiology for our patient's multiple cerebrovascular stenoses and infarctions. Associations between thyroid disease and cerebral vasculitis 19 and between thyroid disease and temporal arteritis 20,21 have been described; however, the angiographic pattern in our patient was more consistent with moyamoya vasculopathy, and her cerebrospinal fluid had no white cells or elevated protein to suggest ongoing vasculitis.…”

Section: A B C Dcontrasting

confidence: 69%

A 10-Year-Old Girl With Coexistent Moyamoya Disease and Graves' Disease

et al. 2005

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There are rare reports of young women with moyamoya disease associated with Graves' disease; we are unaware of any previous reports of this association in prepubescent girls. We report a 10-year-old girl who presented with multiple bilateral strokes. Cerebral angiography demonstrated moderate to severe stenosis of her bilateral distal internal carotid arteries and proximal anterior and middle cerebral arteries, which was greater on the right. Thyroid function tests demonstrated suppressed thyroid-stimulating hormone and elevated thyroid hormone levels. Serum antiphospholipid antibody screen demonstrated mild elevations of antiocardiolipin IgG. Possible mechanisms predisposing individuals to concurrent moyamoya and Graves' disease are discussed.

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Section: A B C Dcontrasting

confidence: 69%

A 10-Year-Old Girl With Coexistent Moyamoya Disease and Graves' Disease

et al. 2005

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“…In the cases detected, the diagnosis of GD and EAATD were done according to the current criteria. Features compatible with EAATD without a defined diagnosis of the disease were disclosed in three GD patients [25,26]. Language limitations (Japanese, Slovak) and availability of the abstract only did not allow the proper data collection for confirming GD diagnosis and reporting exhaustively the clinical and biological features of two patients [27,28].…”

Section: Methodsmentioning

confidence: 99%

Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes

et al. 2010

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BackgroundThe encephalopathy associated with autoimmune thyroid disease (EAATD) is characterized by neurological/psychiatric symptoms, high levels of anti-thyroid antibodies, increased cerebrospinal fluid protein concentration, non-specific electroencephalogram abnormalities, and responsiveness to the corticosteroid treatment in patients with an autoimmune thyroid disease. Almost all EAATD patients are affected by Hashimoto's thyroiditis (HT), although fourteen EAATD patients with Graves' disease (GD) have been also reported.MethodsWe have recorded and analyzed the clinical, biological, radiological, and electrophysiological findings and the data on the therapeutic management of all GD patients with EAATD reported so far as well as the clinical outcomes in those followed-up in the long term.ResultsTwelve of the fourteen patients with EAATD and GD were women. The majority of GD patients with EAATD presented with mild hyperthyroidism at EAATD onset or shortly before it. Active anti-thyroid autoimmunity was detected in all cases. Most of the patients dramatically responded to corticosteroids. The long term clinical outcome was benign but EAATD can relapse, especially at the time of corticosteroid dose tapering or withdrawal. GD and HT patients with EAATD present with a similar clinical, biological, radiological, and electrophysiological picture and require an unaffected EAATD management.ConclusionsGD and HT equally represent the possible background condition for the development of EAATD, which should be considered in the differential diagnosis of all patients with encephalopathy of unknown origin and an autoimmune thyroid disease, regardless of the nature of the underlying autoimmune thyroid disease.

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“…The association with GD was first published by Kushima et al's study on two young Asian women [ 5 ]. Most reports come from Asia, three cases have been reported in Latin America so far (all of them female patients): two in Brazil [ 6 ] and one in Colombia [ 7 ]. To the best of our knowledge, this is the first report of a Peruvian patient with concomitant MMS and GD.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Ischemic Strokes Secondary to Moyamoya Syndrome Associated With Graves Thyrotoxicosis in a Patient of Amerindian Descent From Peru: A Case Report

Ramírez-Quiñones¹,

Wahlster²,

Barrientos-Imán³

et al. 2022

Cureus

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Moyamoya disease (MMD) is characterized by progressive stenosis of the distal portion of the internal carotid artery and its two main branches, the middle cerebral artery, and the anterior cerebral artery. Clinically, MMD can present with ischemic or hemorrhagic cerebrovascular events. The term Moyamoya syndrome (MMS) is used when the characteristic Moyamoya vasculopathy presents in association with other conditions such as Graves' disease (GD). We report a case of a 34-year-old, right-handed male patient of Amerindian descent. He presented to the emergency room with a two-month history of palpitation, fatigue, and weight loss associated with sudden-onset left hemiparesis, facial asymmetry, and dysarthria. His workup was remarkable for elevated levels of thyroid hormones with the presence of autoantibodies and radiological findings typical of MMS. Moyamoya syndrome in association with Graves' disease has increasingly been noted in Latin American patients and should be considered in the differential diagnosis in the appropriate clinical context.

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Vasculite cerebral e doença de Basedow-Graves: relato de dois casos

Cited by 8 publications

References 16 publications

A 10-Year-Old Girl With Coexistent Moyamoya Disease and Graves' Disease

A 10-Year-Old Girl With Coexistent Moyamoya Disease and Graves' Disease

Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes

Bilateral Ischemic Strokes Secondary to Moyamoya Syndrome Associated With Graves Thyrotoxicosis in a Patient of Amerindian Descent From Peru: A Case Report

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