Toxoplasma gondii myelitis in a patient with adult T-cell leukemia-lymphoma

Maciel, Edvaldo Vasconcelos Soares; Siqueira, Isadora Cristina de; Queiroz, Adriano; Melo, Aílton

doi:10.1590/s0004-282x2000000600019

Cited by 18 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cancer can also reactivate latent T. gondii infection during antitumor treatment process (Frenkel et al, 1978). A variety of malignancies, including lymphoma, leukemia, and myeloma, can reactivate toxoplasmosis (Maciel et al, 2000; Kojima et al, 2010). Transplantation of an organ from seropositive donor can activate latent infection in a seronegative recipient receiving immunotherapy (Chehrazi-Raffle et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis

Wang¹,

Liu

Ma³

et al. 2017

Front. Microbiol.

167

164

View full text Add to dashboard Cite

Toxoplasma gondii has been suggested as an important opportunistic pathogen in immunocompromised patients. We conducted a global meta-analysis to assess the prevalence and odds ratios (ORs) of T. gondii infection in immunocompromised individuals. Electronic databases were reviewed for T. gondii infection in HIV/AIDS patients, cancer patients, and transplant recipients, and meta-analyses were conducted to calculate overall estimated prevalence and ORs using random or fixed-effects models. Totally, 72 eligible studies were included. The estimated pooled prevalence of T. gondii infection in immunocompromised patients and the control was 35.9 and 24.7% (p < 0.001), with an OR of 2.24, i.e., 42.1 and 32.0% for HIV/AIDS patients and the control (p < 0.05), 26.0 and 12.1% for cancer patients and the control (p < 0.001), and 42.1 and 34.5% for transplant recipients and the control (p > 0.05), whose estimated pooled ORs were 1.92 (95% CI, 1.44–2.55), 2.89 (95% CI, 2.36–3.55), and 1.51 (95% CI, 1.16–1.95), respectively. This study is the first to demonstrate that the immunocompromised patients are associated with higher odds of T. gondii infection, and appropriate prevention and control measures are highly recommended for these susceptible populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis

Wang¹,

Liu

Ma³

et al. 2017

Front. Microbiol.

167

164

View full text Add to dashboard Cite

show abstract

“…Few reports were published describing myelitis in humans infected with T. gondii. Spinal cord pathology becomes clinically manifested mostly in patients with severe immunosuppressive disorders due to CD4 immune cell defi cits, for example, acquired immunodefi ciency syndrome (AIDS) or T-cell leukemia-lymphoma [6,7]. Moreover, Toxoplasma myelitis was reported after peripheral stem cell transplantation [8].…”

Section: Introductionmentioning

confidence: 99%

Spinal cord pathology in chronic experimentalToxoplasma gondiiinfection

Möhle¹,

Parlog²,

Pahnke³

et al. 2014

European Journal of Microbiology and Immunology

View full text Add to dashboard Cite

Infection with the protozoan Toxoplasma (T.) gondii causes chronic infection of the central nervous system and can lead to lifethreatening encephalomyelitis in immunocompromised patients. While infection with T. gondii has long time been considered asymptomatic in immunocompetent hosts, this view is challenged by recent reports describing links between seropositivity and behavioral alterations.However, past and current researches are mainly focused on the brain during Toxoplasma encephalitis, neglecting the spinal cord as a key structure conveying brain signals into motion. Therefore, our study aimed to fill the gap and describes the spinal cord pathology in an experimental murine model of toxoplasmosis.In the spinal cord, we found distinct histopathological changes, inflammatory foci and T. gondii cysts similar to the brain. Furthermore, the recruitment of immune cells from the periphery was detected. Moreover, resident microglia as well as recruited monocytes displayed an increased MHC classes I and II expression. Additionally, the expression of pro-and anti-inflammatory cytokines was enhanced in the brain as well as in the spinal cord. In summary, the pathology observed in the spinal cord was similar to the previously described changes in the brain during the infection.This study provides the first detailed description of histopathological and immunological alterations due to experimental T. gondii induced myelitis in mice. Thus, our comparison raises awareness of the importance of the spinal cord in chronic T. gondii infection.

show abstract

“…Review of the literature [1,2,3,5,6,7,10,11,12,13,14, 15,16,17,18,19,20,23,24,25,26,27,29,30,32,33] shows that virtually all cases of toxoplasmic myelitis or spinal cord lesions occurred either in persons who were immunecompromised by HIV infections or malignancies or their treatments or occasionally in infants with congenital toxoplasmosis at birth [3,23,28]. Herein, we describe our experience in the US National Collaborative Congenital Toxoplasmosis Study, where we have encountered 3 newborn infants with toxoplasmic spinal cord lesions.…”

Section: Discussionmentioning

confidence: 99%

Spinal Cord Lesions in Congenital Toxoplasmosis Demonstrated with Neuroimaging, Including Their Successful Treatment in an Adult

Burrowes

Boyer²,

Swisher³

et al. 2012

J. Neuroparasitol.

View full text Add to dashboard Cite

Neuroimaging studies for persons in the National Collaborative Chicago-Based Congenital Toxoplasmosis Study (NCCCTS) with symptoms and signs referable to the spinal cord were reviewed. Three infants had symptomatic spinal cord lesions, another infant a Chiari malformation, and another infant a symptomatic peri-spinal cord lipoma. One patient had an unusual history of prolonged spinal cord symptoms presenting in middle age. Neuroimaging was used to establish her diagnosis and response to treatment. This 43 year-old woman with congenital toxoplasmosis developed progressive leg spasticity, weakness, numbness, difficulty walking, and decreased visual acuity and color vision without documented re-activation of her chorioretinal disease. At 52 years of age, spinal cord lesions in locations correlating with her symptoms and optic atrophy were diagnosed with 3 Tesla MRI scan. Treatment with pyrimethamine and sulfadiazine decreased her neurologic symptoms, improved her neurologic examination, and resolved her enhancing spinal cord lesions seen on MRI.

show abstract

Toxoplasma gondii myelitis in a patient with adult T-cell leukemia-lymphoma

Cited by 18 publications

References 10 publications

Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis

Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis

Spinal cord pathology in chronic experimentalToxoplasma gondiiinfection

Spinal Cord Lesions in Congenital Toxoplasmosis Demonstrated with Neuroimaging, Including Their Successful Treatment in an Adult

Contact Info

Product

Resources

About