Polimiosite associada a infecção por HTLV-I: relato de caso

Oliveira, Herbet Alves de; Macieira, José Caetano; Fakhouri, Ricardo

doi:10.1590/s0004-282x2000000500025

Cited by 3 publications

(1 citation statement)

References 8 publications

(10 reference statements)

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“…Some studies implicate viral and bacterial infections as possible triggering factor of the pathogenic process 9,15,16 . Others enroll immune disturbances and genetic profiles as causative determinants for the onset of PM and DM.…”

Section: Levels Of Serum Aldolase (Ui/l)mentioning

confidence: 99%

Polymyositis: clinical investigation in two sisters

Karnikowski

Costa

Osella

et al. 2002

Arq. Neuro-Psiquiatr.

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-We present an investigation of a case of polymyositis affecting two sisters of one same parenthood. Their cases have been documented for almost two decades, being investigated by means of a diagnostic protocol which combined clinical findings as well as laboratorial, histopathological and image tests. In both cases, clinical manifestations started in childhood, without signs of involvement of the central and peripheral nervous system. Both patients proved to respond to a therapeutics based on corticosteroids. The degree of relatedness between their parents corroborate the notion that genetic factors may contribute to the development of the disease.KEY WORDS: polymyositis, inflammatory myopathy.

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Section: Levels Of Serum Aldolase (Ui/l)mentioning

confidence: 99%

Polymyositis: clinical investigation in two sisters

Karnikowski

Costa

Osella

et al. 2002

Arq. Neuro-Psiquiatr.

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Muscle Wasting Induced by HTLV-1 Tax-1 Protein

Ozden

Mouly

Prévost

et al. 2005

The American Journal of Pathology

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Besides tropical spastic paraparesis/human T-cell leukemia virus type-1 (HTLV-1)-associated myelopathy, the human retrovirus HTLV-1 causes inflammatory disorders such as myositis. Although the pathogenesis of HTLV-1-associated myositis is primarily unknown, a direct effect of cytokines or viral proteins in myocytotoxicity is suspected. We have developed an in vitro cell culture model to study the interactions between primary human muscle cells and HTLV-1 chronically infected cells. When HTLV-1-infected cell lines were added to differentiated muscle cultures, cytopathic changes such as fiber shrinking were observed as early as 1 day after contact. This was accompanied by alterations in desmin and vimentin organization, occurring in the absence of muscle cell infection but with Tax-1 present in myotubes. Cytopathic changes were also observed when infected culture supernatants were added to the muscle cells. Fiber atrophy and cytoskeletal disorganization were confirmed in muscle biopsies from two HTLV-1-infected patients with myositis. Transduction of cultured muscle cells with a lentiviral vector containing the HTLV-1 Tax gene reproduced such effects in vitro. The present data indicate that the myocytotoxicity that is observed in HTLV-1-associated myopathies can be due to a direct effect of the Tax-1 protein expressed in infected inflammatory cells, in the absence of muscle cell infection.

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Immunopathogenesis and neurological manifestations associated to HTLV-1 infection

Souza¹,

Tanajura

Toledo-Cornell

et al. 2012

Rev. Soc. Bras. Med. Trop.

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The human T lymphotropic virus type-1 (HTLV-1) was the first human retrovirus identified. The virus is transmitted through sexual intercourse, blood transfusion, sharing of contaminated needles or syringes and from mother to child, mainly through breastfeeding. In addition to the well-known association between HTLV-1 and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), several diseases and neurologic manifestations have been associated with the virus. This review was conducted through a PubMed search of the terms HTLV-1, immune response and neurological diseases. Emphasis was given to the most recent data regarding pathogenesis and clinical manifestations of HTLV-1 infection. The aim of the review is to analyze the immune response and the variety of neurological manifestations associated to HTLV-1 infection. A total of 102 articles were reviewed. The literature shows that a large percentage of HTLV-1 infected individuals have others neurological symptoms than HAM/TSP. Increased understanding of these numerous others clinical manifestations associated to the virus than adult T cell leukemia/lymphoma (ATLL) and HAM/TSP has challenged the view that HTLV-1 is a low morbidity infection.

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Polimiosite associada a infecção por HTLV-I: relato de caso

Cited by 3 publications

References 8 publications

Polymyositis: clinical investigation in two sisters

Polymyositis: clinical investigation in two sisters

Muscle Wasting Induced by HTLV-1 Tax-1 Protein

Immunopathogenesis and neurological manifestations associated to HTLV-1 infection

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