Chronic insomnia in workers poisoned by inorganic mercury: psychological and adaptive aspects

Rossini, Sueli; Reimão, Rubens; Lefèvre, Beatriz Helena

doi:10.1590/s0004-282x2000000100005

Cited by 12 publications

(7 citation statements)

References 17 publications

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“…Gonzalez-Ramirez et al 30 (1998) 65 A análise da avaliação médica desses trabalhadores será objeto de futura publicação. Constatou-se que os problemas surgiram ora na vigência da exposição, ora muito tempo depois da exposição.…”

Section: Tratamento Com Agentes Quelantesunclassified

Mercuralismo metálico crônico ocupacional

Faria

2003

Rev. Saúde Pública

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ResumoRevisão que analisa os conhecimento atuais das manifestações do mercuralismo crônico ocupacional. Avaliaram-se os principais estudos e revisões científicas concernentes às formas clínicas e fisiopatogenia desta intoxicação. Foram pesquisadas, entre outras fontes, as bases de dados Medline e Lilacs. O eretismo ou a síndrome neuropsíquica caracterizada por sintomas de irritabilidade, ansiedade, mudanças de comportamento, apatia, perda da auto-estima e de memória, depressão, insônia, delírio, cefaléia, dores musculares e tremores é observada após a exposição ao mercúrio metálico. Manifestações de hipertensão arterial, renais, imunológicas e alérgicas são freqüentes. A falta de medidas preventivas aumenta o risco da doença em indústrias, no garimpo e consultórios odontológicos. A legislação brasileira assinala 16 manifestações clínicas determinadas pela intoxicação, todavia ocorre subdiagnóstico. O diagnóstico clínico é importante e as novas tecnologias médicas podem detectar alterações do sistema nervoso central, renal e imunológico, proporcionando avanços no conhecimento neuroimuno-toxicológico e nas medidas de prevenção do mercuralismo. Abstract

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Section: Tratamento Com Agentes Quelantesunclassified

Mercuralismo metálico crônico ocupacional

Faria

2003

Rev. Saúde Pública

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“…Insomnia and other sleep disorders have been reported subsequent to mercury exposure in worker in fluorescent light bulb plants (Rossini et al, 2000), among sport-fishers in Wisconsin (Knobeloch et al, 2006), among dental assistants exposed to mercury-containing amalgam used in fillings (Moen et al, 2008), among gold miners in Indonesia (Bose-O’Reilly et al, 2016), and among Iranian workers gilding a shrine (Vahabzadeh and Balali-Mood, 2016). Additional research is needed to address the mechanism underlying these sleep disruptions observed with mercury exposure.…”

Section: Introductionmentioning

confidence: 99%

Metals and Circadian Rhythms

Parmalee

Aschner

2017

Advances in Neurotoxicology

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Circadian rhythms describe the behavioral and physiological changes that occur in living organisms in order to attune to a 24 hour cycle of day and night. The most striking aspect of circadian function is the sleep-wake cycle, however many other physiological processes are regulated in 24 hour oscillations, including blood pressure, body temperature, appetite, urine production, and the transcription and translation of thousands of circadian dependent genes. Circadian disruption and sleep disorders are strongly connected to neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease as well as others. Metal exposures have been implicated in neurodegenerative diseases, in some cases involving metals that are essential micronutrients but are toxic at high levels of exposure (such as manganese, copper, and zinc), and in other cases involving metals that have no biological role but are toxic to living systems (such as lead, mercury, and aluminum). In this review, we examine the evidence for circadian and sleep disorders with exposures to these metals and review the literature for possible mechanisms. We suggest that giving the aging population, the prevalence of environmental exposures to metals, and the increasing prevalence of neurodegenerative disease in the aged, more research into the mechanisms of circadian disruption subsequent to metal exposures is warranted.

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“…Urban workers may become Hg-contaminated through the use of agro-toxic substances containing chlorine-alkalis, the industrial production of Hg-lamps and medical equipment, and the sterilisation of surgical equipments with mercury tensiometres and the handling of dental mixtures containing Hg [5]. Mercury is a potent enzyme inhibitor, with high affinity for -SH groups, highmolecular-weight proteins with membrane structural function [6].…”

Section: Introductionmentioning

confidence: 99%

High-Dilutions as Mercury’s Chelating Agent

Paschalicchio¹

2017

IJCAM

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Background: Mercury (Hg) is one of most relevant toxic metals. High Hg concentrations in professional environments are detected. During years they have been searching forms to decrease heavy metals toxicity in vivo using chelating agents or other competitive substances. The same toxic metal high-dilutions, shows its effectiveness, even pre or post treated poisonings. Homeopathy can act controlling metal poisoning levels in leaving organism.Objectives: This work proposal was to evaluate the homeopathic medication action during Hg contaminated patients' treatment, observing mercury concentration in different tissues.Methods: 52 patients were evaluated clinical and laboratorial. They had been selected and distributed blindly and at random in 2 groups Placebo and Mercurius solubilis. The choice of the homeopathic medication was made from the similitude homeopathic principle. Those patients had been submitted to the Hg blood, urine and in the hair analyses and life quality questionnaire (SF36) before the beginning of the treatment, in 30 and 60 days also.Results: By the end of the treatment it had a significant Hg hair level reduction in those individuals treated with homeopathic medication, beyond the presence of indications of the increase Hg urinary elimination and improvement of aspects of the quality of life as functional capacity, vitality and reduction of painful sensation. Conclusion:This study showed that Hg high-dilution was effective in treating mercury contamination, without collateral effects as chemical agents. Further studies with a bigger population are necessary to a greater comprehension about the effectiveness of the homeopathic treatment.

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Chronic insomnia in workers poisoned by inorganic mercury: psychological and adaptive aspects

Cited by 12 publications

References 17 publications

Mercuralismo metálico crônico ocupacional

Mercuralismo metálico crônico ocupacional

Metals and Circadian Rhythms

High-Dilutions as Mercury’s Chelating Agent

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