1995
DOI: 10.1590/s0004-282x1995000400005
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Esthesioneuroblastomas with intracranial extension: proliferative potential and management

Abstract: SUMMARY -A total of 15 patients with esthesioneuroblastomas were treated between 1978 and 1992 at the Neurosurgery Department, Nordstadt Hospital, Hannover. In 9 cases, the tumors invaded the anterior cranial fossa. One patient died before any surgical intervention. Eight tumors were operated by a combined paranasal and subfrontal approach. Gross total tumor removal was achieved in all cases. Apart from anosmia, the only postoperative complication was transient mental changes in one case. Immunohistochemical a… Show more

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Cited by 18 publications
(18 citation statements)
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“…The 26 studies 2,[4][5][6]8,43,[54][55][56][57][58][60][61][62][63][64][65][66][68][69][70][71][72][73]77,78 reported on 390 patients with ENB. Overall survival at 5 years could be extracted from 25 studies; the mean was 45% (SD 22), with extremes of 86% 58 and zero.…”
Section: Resultsmentioning
confidence: 99%
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“…The 26 studies 2,[4][5][6]8,43,[54][55][56][57][58][60][61][62][63][64][65][66][68][69][70][71][72][73]77,78 reported on 390 patients with ENB. Overall survival at 5 years could be extracted from 25 studies; the mean was 45% (SD 22), with extremes of 86% 58 and zero.…”
Section: Resultsmentioning
confidence: 99%
“…Overall survival at 5 years could be extracted from 25 studies; the mean was 45% (SD 22), with extremes of 86% 58 and zero. 57 Disease-free survival at 2 years was found in 17 studies, 2,43,[54][55][56][57][58]60,62,65,66,[68][69][70][71]73,78 that at 3 years in 20 reports 4,6,8,43,[54][55][56][57][58]60,62,65,66,[68][69][70][71][72][73]78 and that at 5 years in 24 publications. 2,4,6,8,43,[54][55][56][57][58][60][61]…”
Section: Resultsmentioning
confidence: 99%
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“…The behaviour of a brain neoplasm is not predictable by routine pathological diagnosis. Many parameters are involved in order to analize the biological behaviour of a brain tumor, however the proliferative index evaluated by MIB-1 has been applied to different types of brain neoplasm with important prognostic correlation [1][2][3][4][5][6][7] . MIB -1 is a monoclonal antibody (ma) which binds to a nucleolar proteins in the proliferative cell receptors, in all steps of the celular cycle, except in Go phase 8 .…”
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confidence: 99%