Esclerose múltipla: análise clínica e evolutiva de 214 casos

Tilbery, Charles Peter; Felipe, Eduardo; Baldauf, Cristine; Peres, Mário Fernando Prieto

doi:10.1590/s0004-282x1995000200003

Cited by 13 publications

(8 citation statements)

References 17 publications

(10 reference statements)

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“…The pre d o m i n a nce of Caucasians affected by the disease in our group seems to be higher than that reported in other Reference Centers in Brazil [7][8][9][10][11][12][13][14] .…”

Section: Discussioncontrasting

confidence: 76%

Description and characteristics of 81 patients attending the Reference Center for Multiple Sclerosis of the coastal region of the state of São Paulo - Brazil

Fragoso

Fiore

2005

Arq. Neuro-Psiquiatr.

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-O b j e c t i v e :65% of all patients were residents of the city of Santos. The mean age of these patients was 43 years (14 to 74 years), and the Expanded Disability Status Scale (EDSS) was ≤ 5.5 in 76.5% of the cases. 82.7% of the assessed patients presented the re l a p s i n g / remitting form of MS. 81.5% of all patients were underg o i n g t reatment with immunomodulators. Conclusion: Due to their clinical profile, patients seem to come to CEREM Litoral Paulista for prescription of immunomodulators. There is a clear need to identify other cases in the region and to allow other forms of treatment to be put into practice.KEY WORDS: multiple sclerosis, immunomodulators, city of Santos.Descrição e características dos 81 pacientes em seguimento no Centro de Referência em Esclero s e Múltipla do litoral paulista. RESUMO -Objetivo: Registrar os pacientes portadores de esclerose múltipla (EM) residentes na região do litoral paulista (CEREM Litoral Paulista). Método: Entrevistas individuais com casos identificados de EM.Resultados: 81 indivíduos com diagnóstico de EM (62 mulheres [76,5%] e 19 homens [23,5%]) concord a r a m em comparecer para re g i s t ro no centro. 65% do grupo total de pacientes eram residentes da cidade de S a n t o s . A idade média destes pacientes era 43 anos (14 a 74 anos), e o Expanded Disability Status Scale (EDSS) foi < 5,5 em 76,5% dos casos. 82,7% dos pacientes registrados apresentava a forma re m i t e n t e -re c o rrente de E M . 81,5% de todos os pacientes estava recebendo tratamento com imunomoduladore s . Conclusão: Pelo perfil clínico, os pacientes parecem vir ao CEREM Litoral Paulista para prescrição de imunomoduladores. Existe uma clara necessidade de identificar outros casos na região e permitir que outras formas de tratamento sejam implantadas.

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“…The pre d o m i n a nce of Caucasians affected by the disease in our group seems to be higher than that reported in other Reference Centers in Brazil [7][8][9][10][11][12][13][14] .…”

Section: Discussioncontrasting

confidence: 76%

Description and characteristics of 81 patients attending the Reference Center for Multiple Sclerosis of the coastal region of the state of São Paulo - Brazil

Fragoso

Fiore

2005

Arq. Neuro-Psiquiatr.

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“…O predomínio da doença no gênero feminino é relatado por todos autores, havendo apenas diferenças de incidência de uma série para outra (Lana e Lana encontraram 1:2,3; Callegaro 1:1,6; Leite e col. 1:2,1) [13][14][15][16][18][19][20][21] .…”

Section: Discussionunclassified

Esclerose múltipla: estudo descritivo de suas formas clínicas em 302 casos

Moreira

Felipe

Mendes

et al. 2000

Arq. Neuro-Psiquiatr.

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RESUMO -A esclerose múltipla é uma das causas mais comuns de incapacidade neurológica crônica em adultos jovens. Avaliamos, através de estudo retrospectivo, características epidemiológicas, formas de apresentação, manifestações clínicas, evolução e o grau de incapacitação física da esclerose múltipla em 302 pacientes. A média da idade dos pacientes foi 37,7 anos e a relação entre os gêneros foi 3,13F:1M. A média da idade no início da doença foi 29,6 anos. Duzentos e oitenta e três pacientes eram brancos (94%), 15 negros (5%) e 4 amarelos (1%). Duzentos e vinte pacientes (72%) apresentaram forma clínica tipo remitente-recorrente. Oitenta e dois pacientes (28%) apresentaram a forma progressiva (50% forma secundária e 50% forma primariamente progressiva). Os sintomas iniciais mais comuns foram sensitivos (31,7%) e ópticos (26,8%).Em relação aos sintomas evolutivos predominavam os sintomas piramidais (72,5%) e os medulares (64,9%). A média do escore do EDSS final foi 3,37 e a do NRS foi 85,17. O índice anual de surtos foi 0,45. Nossos achados coincidem com os da literatura mundial, e ressaltam que 60 pacientes (19,8%) apresentavam esclerose múltipla de forma benigna de valor prognóstico. PALAVRAS-CHAVES: esclerose múltipla, estudo descritivo, formas evolutivas. Multiple sclerosis: descriptive study of the clinical forms in 302 casesABSTRACT -Multiple sclerosis (MS) is one of the most common causes of chronic neurologic disability in young adults. We evaluate, through retrospective study, the epidemiological characteristics, the manifestations ways, the clinical manifestations, the evolution and the level of physical disability of MS in 302 patients. The average patients age was 37.7 and the relation between genders was 3.13F:1M. The average age at the beginning of MS was 29.6; 283 patients were white (94%), 15 patients were black (5%) and 4 patients were yellow; 220 patients (72%) presented relapsing-remmiting clinical form; 82 patients (28%) presented the progressive form (50% secondary form and 50% primarily progressive form). The most common initial symptoms were sensitive (31.7%) and optical (26.8%). The most common evolutive symptoms were pyramidal (72.5%) and of the spinal cord (64.9%). The average of the final EDSS was 3.37 and final NRS was 85.17. The index of the annual outbreak was 0.45. Our findings coincide to the ones in the worldwide literature, however it is important to point out that 60 patients (19.8%) presented benign MS of prognostic value.KEY WORDS: multiple sclerosis, descriptive study, evolutive forms.A esclerose múltipla (EM) é a desordem desmielinizante mais comum do sistema nervoso central (SNC), caracterizada por episódios repetidos de disfunção neurológica com remissão variável 1 .

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“…14 found brainstem alterations in 28.4% of early MS patients and in 28.5% of patients with progressed MS. Tilbery et al 15 found signs and symptoms of brainstem alteration in 32% of patients with early MS and in 52% of patients with progressed disease.…”

Section: Discussionmentioning

confidence: 98%

Alterações dos potenciais evocados auditivos do tronco encefálico em pacientes com esclerose múltipla

Lima¹,

Crato²,

Mancini³

et al. 2009

Rev. Bras. Otorrinolaringol.

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Al terations in early auditory evoked potentials (EAEP) in individuals with demyelinating disease are suggestive of lesions in the brainstem. Aim: this study aims to evaluate the prevalence of hearing disorders and altered EAEP in multiple sclerosis (MS) patients. Materials and method: sixteen female and nine male patients with a defined diagnosis of multiple sclerosis took part in this study. All individuals underwent hearing and EAEP tests. The wave forms were categorized according to Jerger (1986). Results: fifty EAEP tests were carried out; 70% were classified as type I (normal response) according to Jerger's criteria. Altered EAEP results in at least one ear were classified into types II, III, IV or V according to Jerger. Females accounted for 31.25% of alterations, and males 44.44%, adding up to 36% of all cases. Conclusions: these findings stress the importance of looking at EAEP in cases where there is suspicion of demyelinating disease and in patients with a defined diagnosis for MS.

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Esclerose múltipla: análise clínica e evolutiva de 214 casos

Cited by 13 publications

References 17 publications

Description and characteristics of 81 patients attending the Reference Center for Multiple Sclerosis of the coastal region of the state of São Paulo - Brazil

Description and characteristics of 81 patients attending the Reference Center for Multiple Sclerosis of the coastal region of the state of São Paulo - Brazil

Esclerose múltipla: estudo descritivo de suas formas clínicas em 302 casos

Alterações dos potenciais evocados auditivos do tronco encefálico em pacientes com esclerose múltipla

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