Intracranial saccular aneurysm

Background and PurposeThe familial occurrence of intracranial aneurysms suggests the presence of a genetically determined underlying arteriopathy. The pattern of inheritance in these families usually is not known.Methods A family with seven members with intracranial aneurysms is described and, from the literature before 1994, a total of 238 families with 560 affected members (56% female and 44% male) with intracranial aneurysms not associated with a known heritable disease are reviewed. A segregation analysis was performed on 73 of these families.Results Two members were affected in the great majority of families (79%); five or more members were reported in only eight families (3%). The most common affected kinship was among siblings. Angiographic screening in 12 families detected an intracranial aneurysm in 29% of 51 asymptomatic relatives. Segregation analysis revealed several patterns of inheritance

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On the inheritance of intracranial aneurysms.

Schievink

Schaid

Rogers

et al. 1994

Stroke

115

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Intracranial saccular aneurysm

Cited by 1 publication

References 26 publications

On the inheritance of intracranial aneurysms.

On the inheritance of intracranial aneurysms.

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