Slowly progressive aphasia followed by Alzheimer' s dementia: a case report

Abstract

Slowly progressive aphasia has been found in 8 published cases, 2 of whom progressed over a period of years to generalized dementia. Positron emission tomography demonstrated decreased glucose metabolism in the left perisylvian region in 2 cases. We describe a patient who had slowly progressive aphasia and developed generalized Alzheimer's dementia 7 years after presentation. There was no clinical or laboratory evidence of concomitant disease. Computerized tomography showed generalized atrophy more marked on the left perisylvian region late in the disease, when EEG showed generalized slowing more marked on the same area. Slowly progressive aphasia of old age should be considered a separate entity until further studies elucidate its relation to Alzheimer's dementia.

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

“…In 1989, Oliveira et al reported a patient with difficulties in comprehension of written texts that were followed by other language disturbances and dementia ( 17 ).…”

“…The authors suggested that motor perseveration was an important sign for early diagnosis and a key element for the clinical characterization of PSP. In 1989, Oliveira et al reported a patient with difficulties in comprehension of written texts that were followed by other language disturbances and dementia (17).…”

Focal Cortical Atrophy Syndromes

“…Associated symptoms and the question of dementia. Although most case studies of PPA have concentrated on the primary language characteristics and performance on standardized neuropsychological tests, a few studies have looked more closely at deficits that could be expected to be associated with aphasia based on the study of focal lesions, including verbal and limb Kirshner, Tanridag, & Whetsell, 1987;Chawluk, Mesulam, Hurtig, Kushner, Weintraub, Saykin, Ruby, Alavi, & Reivich, 1986; Case Records of the Massachusetts General Hospital, 1986;Hamanaka & Yamagishi, 1986;Mehler, Horoupian, Davies, & Dickson, 1987;Basso, Capitani, & Laiacona, 1988;Poeck & Luzzatti, 1988;Cummings, Darkins, Mendez, Hill, & Benson, 1988;Goulding, Northern, Snowden, MacDermott, & Neary, 1989;DeOliveira & De O Castro, 1989;Kushner, 1989;Yamamoto, Tanabe, Kashiwagi, et al, 1989;Graff-Radford, Damasio, Hyman, 1990;Bondi, Monsch, Galasko, Butter, Salmon, & Delis, 1994;Northern, Hopcutt, & Griffiths, 1990;Scheltens, Hazenberg, Lindeboom, Valk, & Wolters, 1990;Weintraub, Rubin, & Mesulam, 1990;Kempler, Metter, Riege, Jackson, Benson, & Hanson, 1990;Tyrrell, Warrington, Frackowiak, & Rossor, 1990;Delecluse, Andersen, Waldemar, Thomsen, Kjaer, Lassen, & Postiglione, 1990;Kartsounis, Crellin, Crewes, & Toone, 1991;Tyrrell, Kartsounis, Frackowiak, Findley, & Rossor, 1991;Benson & Zaias, 1991;McDaniel, Wagner, & Greenspan, 1991;Blin, Vidailhet, Pillon, Dubois, Feve, & Agid, 1992;McKeith, Fairbairn, Bothwell, Moore, Ferrier, Thompson, & Perry, 1994;).…”

Demência semântica

“…Quanto à primeira questão, devemos dizer que o excelente artigo de Oliveira et al 1 foi pioneiro na caracterização de um caso brasileiro de afasia lentamente prog ressiva (provavelmente da forma não-fluente), mas não de demência semântica. Os conceitos de demência semântica (nosso caso) e afasia lentamente progressiva (caso do Dr. Paulo Bittencourt) são diferentes, ainda que guardem algumas semelhanças clínicas e possam, em alguns casos, compartilhar a mesma histopatologia.…”