Abstract:The previously described anti-spastic effect of oxcarbazepine and 10,11-dihydro-10-hydroxycarbamazepine was found accidentally in 2 patients undergoing a double-blind comparative study for evaluation of antiepileptic effect. In this study oxcarbazepine was given orally in doses of 300-2700 mg daily to one patient with transverse myelitis and to two patients with multiple sclerosis, all of whom had clinically disabling spasticity in the form of difficulty in walking, lower limb rigidity, spastic contractions of… Show more
“…Successful treatment of tonic spasms has been achieved using carbamazepine (from 100 mg three times daily), oxcarbazepine (300 mg twice daily) or acetazolamide (250 twice daily). 189 Additionally, botulinum toxin treatment has more recently been used with good results. 190 …”
“…Successful treatment of tonic spasms has been achieved using carbamazepine (from 100 mg three times daily), oxcarbazepine (300 mg twice daily) or acetazolamide (250 twice daily). 189 Additionally, botulinum toxin treatment has more recently been used with good results. 190 …”
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