Composição do liquido cefalorrraqueano do recem-nascido normal: citometria, proteinorraquia e bilirrubinorraquia em 79 casos

Luz, Berta R.

doi:10.1590/s0004-282x1975000300002

Arq. Neuro-Psiquiatr.

1975

DOI: 10.1590/s0004-282x1975000300002

|View full text |Cite

Composição do liquido cefalorrraqueano do recem-nascido normal: citometria, proteinorraquia e bilirrubinorraquia em 79 casos

Berta R. Luz¹

Abstract: Estudo do LCR de recém-nascidos a termo e de parto normal, sem intercorrências perinatais, para verificar o quanto a xantocromia é devida à bilirrubinorraquia. Foi verificado que a bilirrubinorraquia é constante na primeira semana de vida e que sua concentração: não guarda relação com a concentração proteica total do LCR e/ou com os níveis de bilirrubina no soro; não sofre influência do número de hemácias e/ou de leucócitos presente na amostra. Os valores encontrados no LCR quanto ao número de leucócitos e de … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1977

2023

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Diagnostic Utility of Cerebrospinal Fluid White Blood Cell Components for the Identification of Bacterial Meningitis in Infants

Lamb,

Rent,

Brannon

et al. 2023

Journal of the Pediatric Infectious Diseases Society

View full text Add to dashboard Cite

Background To evaluate the diagnostic and predictive utility of cerebrospinal fluid (CSF) white blood cell (WBC) components in the diagnosis of bacterial meningitis in infants discharged from the neonatal intensive care unit (NICU). Methods We identified a cohort of infants discharged from a Pediatrix NICU between 1997 and 2020 who did not have an immunodeficiency, had at least 1 CSF culture collected within the first 120 days of life, and at least 1 CSF laboratory specimen obtained on the day of culture collection. We only included an infant’s first CSF culture and excluded cultures from CSF reservoirs and those growing contaminants or nonbacterial organisms. We examined the utility of CSF WBC components to diagnose or predict bacterial meningitis by calculating sensitivity, specificity, positive and negative predictive values, likelihood ratios, and area under the receiver operating curve (AUC) at different cutoff values for each parameter. We performed subgroup analysis excluding infants treated with antibiotics the day before CSF culture collection. Results Of the 20 756 infants that met the study inclusion criteria, 320 (2%) were diagnosed with bacterial meningitis. We found (AUC [95% CI]) CSF WBC count (0.76 [0.73–0.79]), CSF neutrophil count (0.74 [0.70–0.78]), and CSF neutrophil percent (0.71 [0.67–0.75]) had the highest predictive values for bacterial meningitis, even when excluding infants with early antibiotic administration. Conclusions No single clinical prediction rule had the optimal discriminatory power for predicting culture-proven bacterial meningitis, and clinicians should be cautious when interpreting CSF WBC parameters in infants with suspected meningitis.

show abstract

Diagnostic Utility of Cerebrospinal Fluid White Blood Cell Components for the Identification of Bacterial Meningitis in Infants

Lamb,

Rent,

Brannon

et al. 2023

Journal of the Pediatric Infectious Diseases Society

View full text Add to dashboard Cite

show abstract

Normal Values for Cerebrospinal Fluid in Neonates: A Systematic Review

Zimmermann

Curtis

2021

Neonatology

View full text Add to dashboard Cite

Background: The diagnosis of neonatal meningitis often rests on microscopic and biochemical findings in the cerebrospinal fluid (CSF). There is ongoing uncertainty about age-related normal values for CSF findings in neonates, and many previous studies have included infants in whom antibiotics were administered before lumbar puncture or in whom viral meningitis was not excluded. Methods: A systematic search was done using MEDLINE and EMBASE to identify original studies which investigated CSF normal values in either healthy neonates or febrile neonates in whom bacterial and viral meningitis were reliably excluded. Results: We identified seven studies investigating 270 term and 96 preterm neonates. There were minimal differences between preterm and term neonates in the CSF white blood cell (WBC) count and glucose concentration. In contrast, the CSF neutrophil count and protein concentration were influenced by gestational and chronological age. In the four studies that reported individual patient data, in 95% of cases the CSF WBC count was <12 cells/μL in preterm and <10 cells/μL in term neonates, the neutrophil count was <16 and 8 cells/μL, and the protein concentration was <210 and 110 mg/dL, respectively. Conclusion: The normal range for CSF parameters in neonates is different to that in older infants, and some parameters are influenced by gestational and chronological age. CSF parameters alone are not sufficiently reliable to exclude meningitis.

show abstract

Liquido cefalorraqueano no récem-nascido pré-termo sadio

Vaz

Livramento

Spina-França

1977

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

CASUÍSTICA Ε MÉTODOSForam estudados 54 RN-PT normais, sem intercorrências perinatais. A idade gestacional era inferior a 37 semanas em todos os casos (média de 33,8 semanas: desvio padrão 2,34). O parto foi não-traumático, sendo normal em 26 casos, pélvico em 8, mediante forceps em 6 e mediante cesárea em 14. Todos os RN obtiveram notas de 6 a 9 no 5"? minuto de vida, segundo a avaliação de Apgar ι (6 em dois RN: 7 em 4; 8 em 11 e 9 em 37).O exame clínico e o exame neurológico dos RN foram efetuados conforme as normas estabelecidas por Dubowitz & col. 4 e por Farr 5. Eles foram normais em todos os casos não tendo sido observada qualquer anormalidade durante a primeira semana de vida.Eram do sexo masculino 23 dos RN-PT e 31, do sexo feminino; 27 eram de cor branca e 27. não-brancos. O peso foi inferior a 2.700 g em todos (média de 2.129 g;

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Composição do liquido cefalorrraqueano do recem-nascido normal: citometria, proteinorraquia e bilirrubinorraquia em 79 casos

Cited by 5 publications

References 11 publications

Diagnostic Utility of Cerebrospinal Fluid White Blood Cell Components for the Identification of Bacterial Meningitis in Infants

Diagnostic Utility of Cerebrospinal Fluid White Blood Cell Components for the Identification of Bacterial Meningitis in Infants

Normal Values for Cerebrospinal Fluid in Neonates: A Systematic Review

Liquido cefalorraqueano no récem-nascido pré-termo sadio

Contact Info

Product

Resources

About