Localização encefálica da blastomicose sul-americana. Considerações a propósito de 9 casos

Pereira, Walter C.; Raphael, Açucena; Tenuto, Rolando A.; Sallum, Jamil

doi:10.1590/s0004-282x1965000200006

Cited by 23 publications

(6 citation statements)

References 5 publications

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“…The majority of NPCM patients presented the chronic form of PCM, which is in accordance with the literature 17,18 . Moreover, all the cases reported exhibited the parenchymatous form, mainly supratentorial.…”

Section: Discussionsupporting

confidence: 90%

Paracoccidioidomycosis case series with and without central nervous system involvement

Pedroso

Lyon

Araújo

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Paracoccidioidomycosis (PCM) is the most important systemic mycosis in South America. Central nervous system involvement is potentially fatal and can occur in 12.5% of cases. This paper aims to contribute to the literature describing eight cases of neuroparacoccidioidomycosis (NPMC) and compare their characteristics with patients without neurological involvement, to identify unique characteristics of NPCM. Methods: A cohort of 213 PCM cases was evaluated at the Infectious Diseases Clinic of the University Hospital, Federal University of Minas Gerais, Brazil, from October 1976 to August 2008. Epidemiological, clinical, laboratory, therapeutic and follow-up data were registered. Results: Eight patients presented NPCM. The observed NPCM prevalence was 3.8%. One patient presented the subacute form of PCM and the other seven presented the chronic form of the disease. The parenchymatous form of NPCM occurred in all patients. 60% of the patients who proceeded from the north/ northeast region of Minas Gerais State developed NPCM. The neurological involvement of a mother and her son was observed. NPCM patients exhibited demographical and clinical profiles similar to what is described in the literature. When NPCM cases were compared to PCM patients, there were differences in relation to origin and positive PCM family history. Conclusions: The results corroborate the clinical view that the neurological findings are extremely important in the evaluation of PCM patients. Despite the limitations of this study, the differences in relation to patient's origins and family history point to the need of further studies to determine the susceptibility factors involved in the neurological compromise.

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Section: Discussionsupporting

confidence: 90%

Paracoccidioidomycosis case series with and without central nervous system involvement

Pedroso

Lyon

Araújo

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…Desde a primeira descrição de MPCM, feita por Maffei 9-11 em 1943, cerca de dezesseis casos de MPCM foram acrescentados à literatura nacional [8][9][10][11][12][13] até o momento, mostrando a raridade desta forma em relação a sua apresentação pseudotumoral. Estudo realizado por Paniago 4 em 2000, analisou retrospectivamente 422 pacientes com PCM no HU-UFMS no período de 1980 a 1999 e encontrou envolvimento do SNC em apenas 6 (1,4%) dos pacientes (4 de encéfalo e 2 de medula espinhal), evidenciando a raridade do acometimento do SNC pela PCM e tornando este, o primeiro caso de MPCM descrito em nosso hospital e no Mato Grosso do Sul.…”

Section: Discussionunclassified

“…Os dados fornecidos pelo exame de rotina do LCR em casos de MPCM são inespecíficos, podendo apresentar-se normal ou com pleocitose com predomí-nio linfomononuclear, hiperproteinorraquia (com aumento das gama-globulinas) e hipoglicorraquia, sendo que alguns autores também relatam a hipoclororraquia 2,[5][6][7][8]12,13 . O encontro do fungo no LCR e mesmo seu crescimento em culturas nos meios apropriados é raro 2,[5][6][7]12,13 .…”

Section: Discussionunclassified

“…Esta doença sistêmica pode afetar o sistema nervoso central (SNC) em cerca de 10% dos casos 1,[3][4][5][6][7] , variando de 1 a 27,27% nas séries brasileiras [1][2][3][4][5][6][7][8] , geralmente associada a comprometimento de outros órgãos. A apresentação clínica e anátomo-patológica ocorre sob duas formas: 1) a forma meníngea, com inflamação da leptomeninge, predominante na base do crânio, originando uma leptomeningite semelhante àquela da tuberculosa; 2) a forma granulomatosa, também conhecida como forma pseudotumoral, que se apresenta com granulomas intraparenquimatosos, únicos ou múltiplos, de localização habitualmente supratentorial [1][2][3][4][5][6][7] .…”

Section: Dr Paulo José Lorenzoni -Avenida Santa Bernadete 1828 -8103unclassified

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Meningite paracoccidioidomicótica: relato de caso

Lorenzoni

Chang

Paniago

et al. 2002

Arq. Neuro-Psiquiatr.

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RESUMO -O envolvimento do sistema nervoso central na paracoccidioidomicose tem sido pouco descrito na literatura, sendo rara sua apresentação sob a forma meníngea. Descreve-se o caso de um paciente de 23 anos que desenvolveu meningite paracoccidioidomicótica comprovada pela positividade do fungo na pesquisa direta e cultura do líquido cefaloraquidiano. Discute-se a apresentação da forma meníngea da paracoccidioidomicose, seu diagnóstico laboratorial e neurorradiológico. Destaca-se a importância da investigação rotineira do fungo.PALAVRAS-CHAVE: paracoccidioidomicose, sistema nervoso central, meningite. Paracoccidioidomycosis meningitis: case reportABSTRACT -The involvement of the central nervous system in paracoccidioidomycosis and its meningeal form of clinical presentation have rarely been described. This is a case report of a 23 years old man who developed paracoccidioidomycosis meningitis achieved by fungus' presence in direct research and culture of cerebrospinal fluid. The meningeal form of paracoccidioidomycosis, its laboratorial and imaging diagnostic are discussed, and the importance of the routine investigation of the fungus is emphasized.

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“…Fungal pathogens that cause CNS infections can be classified as either primary pathogens or secondary (opportunistic) pathogens. Primary pathogens are C. neoformans [3][4][5][6] C. immitis, 7 Histoplasma capsulatum, [8][9][10][11][12] Blastomyces dermatitidis, 13,14 Paracoccidioides brasiliensis, 15 Sporothrix schenckii [16][17][18] and Pseudoallescheria boydii. [19][20][21][22] However, it is important to note that clinical predilection for the CNS as an infection site is most common for C. neoformans and C. immitis.…”

Section: Microbiologymentioning

confidence: 99%

Fungal Meningitis

Gottfreðsson¹,

Perfect²

2000

Semin Neurol

115

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Fungi provide many benefits to humans. However, some of these fungi have the ability to become human pathogens. All the major fungal pathogens can produce meningitis. From the common cryptococcal meningitis to the rare fungal meningitis caused by a dimorphic or filamentous fungus, medical issues are discussed in this review on a fungus-specific basis. Both primary (Cryptococcus, Blastomyces, Histoplasma, Coccidioides, and other dimorphic fungi) and secondary (Aspergillus, Candida, and a series of molds) fungal pathogens can produce life-threatening central nervous system infections. These infections require immediate and precise diagnosis and carefully selected management strategies to optimize outcomes. In this review, we examine the epidemiology, pathogenesis, clinical manifestations, and treatment for fungal meningitis in all the major fungal groups.

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Localização encefálica da blastomicose sul-americana. Considerações a propósito de 9 casos

Cited by 23 publications

References 5 publications

Paracoccidioidomycosis case series with and without central nervous system involvement

Paracoccidioidomycosis case series with and without central nervous system involvement

Meningite paracoccidioidomicótica: relato de caso

Fungal Meningitis

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