Esquistossomose medular: Granulomas produzidos por ovos de Schistosoma Mansoni comprimindo a medula, epicone, cone e cauda eqüina

Gama, C; Sá, João Marques de

doi:10.1590/s0004-282x1945000400002

Cited by 27 publications

(15 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first report of SCS in Brazil was made by Gama and Sá in 1945 13 and to date no more than 200 cases have been described, it is believed that this is an under-diagnosed condition. As a rule, most of the series show prevalence in adults ranging from 24 to 40 years 14 .…”

mentioning

confidence: 99%

Spinal cord schistosomiasis in children: analysis of seven cases

Paz

Valente

Casella

et al. 2002

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-We describe seven cases of children (ages 2 to 14 years) with myeloradiculopathy caused by infection with S. mansoni. None of them presented hepatosplenic involvement and one presented an intestinal picture. The myeloradicular and pseudotumoral forms were observed in four and three patients, respectively. Comparing the reports in the literature, we found that the pseudotumoral form is more similary frequent among children than in adults, while the myelitic and myeloradicular forms are the most frequent and distributed across all age groups. Diagnosis is based on clinical and epidemiological findings in association with laboratory tests. The diagnosis was confirmed by the presence of S. mansoni eggs in feces (5 cases) and / or the positivity in specific immunological tests (5 cases) associated with a cerebrospinal fluid inflammatory pattern with presence of eosinophils (between 1 and 24%). Magnetic resonance image, although it does not enable an etiological diagnosis, helped to confirm the form and spinal cord level of the lesion.KEY WORDS: schistosoma mansoni, spinal cord schistosomiasis, schistosomal myelopathy, myelitis, spinalcord pseudotumor, child. Esquistossomose medular em crianças: análise de sete casosRESUMO -Relatamos sete crianças com mielorradiculopatia devida a infecção pelo S. mansoni, com idade entre 2 e 14 anos. Nenhuma apresentou acometimento hepatoesplênico e uma apresentou quadro intestinal. A forma mielorradicular foi observada em quatro pacientes e a pseudotumoral em três. Revendo os achados da literatura, encontramos que a forma pseudotumoral é mais frequente nas crianças que nos adultos, apesar das formas mielíticas e mielorradiculares serem ainda as mais frequentes em todas as idades. O diagnóstico baseou-se nos achados clínicos e epidemiológicos, associados aos laboratoriais. A presença de ovos de S. mansoni nas fezes (5 casos) e/ou a positividade de testes imunológicos específicos no liquido cefalorraquidiano (5 casos), com padrão inflamatório e eosinofilorraquia (entre 1 e 24%) confirmou o diagnóstico. O estudo da imagem de ressonância magnética, apesar de não permitir o diagnóstico etiológico, ajudou a confirmar a forma e o nível medular da lesão. PALAVRAS-CHAVE: esquistosomose mansoni, esquistossomose medular, mielopatia esquistossomótica, mielite, pseudotumor medular, criança. . The prevalence of oviposition in the central nervous system (CNS) varies among studies from 0.3 to 30 percent of infected individuals [3][4][5] . It is generally myeloradicular and occasionally encephalitic, as opposed to Schistosomiasis japonica in which encephalitic involvement is more frequent. Many patients remain asymptomatic. Spinal cord schistosomiasis (SCS) is one of the most frequent causes of non-traumatic myelopathies, responsible for 6% of these in endemic areas 6 . Vascular lesions caused by SM appear to be responsible for the neurological sequels. Vascular obstruction in the spinal cord (SC) is secondary to the formation of a granuloma, with an intense inflammatory reaction and ischem...

show abstract

mentioning

confidence: 99%

Spinal cord schistosomiasis in children: analysis of seven cases

Paz

Valente

Casella

et al. 2002

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…His patient who died fifty days after the acute development of thoracolumbar myelitis was aged 30 years and at P. M., ova of S. mansoni were found in the corresponding segment of the cord. The third report which presented the first case to be diagnosed at operation (during life) was presented by Gama and Sa (1945). Their patient developed rapid paraplegia and myelography disclosed a complete block in the upper lumbar region.…”

Section: Discussionmentioning

confidence: 98%

Schistosomiasis of the Spinal Cord, Conus and Cauda

El-Banhawy

1971

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

“…The difference among those levels (Table 6) is based on the analysis of the CSF abnormal findings intensity that may represent different probabilities of SCS. The specific treatment to SCS must be considered at any of those levels (Table 6) because the prognosis is extremely favorable, if the disease is diagnosed and treated at an early stage [12][13][14][15][16][17] . It is important to emphasize that two negative immunologic reactions do not necessarily exclude the diagnosis of NS.…”

Section: Discussionmentioning

confidence: 99%

“…Some of these difficulties are the scarce knowledge about this illness among physicians, the incomplete or oligosymptomatic or transient evolution of some cases with little functional disturbances, and the operational difficulties at the health institutions regarding investigation and diagnosis 11 . It is important to highlight the necessity of thinking about SCS when any patient reporting contact with schistosome-infected water with non-traumatic myelopathy looks for health assistance 10 , because the treatment is highly composed by oral medication and the prognosis is extremely favorable, if the disease is diagnosed and treated at an early stage [12][13][14][15][16][17] . The purposes of the present investigation are to describe the clinical and CSF findings among patients with presumptive SCS and to suggest a classification for the CSF diagnosis of presumptive SCS.…”

mentioning

confidence: 99%

Clinical and cerebrospinal fluid (CSF) profile and CSF criteria for the diagnosis of spinal cord schistosomiasis

Moreno-Carvalho¹,

Nascimento‐Carvalho

Bacelar

et al. 2003

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Objectives: To describe the clinical and CSF findings among patients with presumptive neuroschistosomiasis (NS) and to suggest a classification for the CSF diagnosis of presumptive NS. Method: The charts of all patients whose CSF exam was performed at the CSF Lab, José Silveira Foundation, Salvador, Brazil, from 1988 Aspectos clínicos e liquóricos e critérios para o diagnóstico liquórico de esquistossomose medular Aspectos clínicos e liquóricos e critérios para o diagnóstico liquórico de esquistossomose medular Aspectos clínicos e liquóricos e critérios para o diagnóstico liquórico de esquistossomose medular Aspectos clínicos e liquóricos e critérios para o diagnóstico liquórico de esquistossomose medular Aspectos clínicos e liquóricos e critérios para o diagnóstico liquórico de esquistossomose medular RESUMO -Objetivos: descrever aspectos clínicos e liquóricos de pacientes com diagnóstico presuntivo de neuroesquistossomose (NE) e sugerir uma classificação para o diagnóstico liquórico presuntivo da NE. Método: as fichas de todos os pacientes cujo exame de líquor (LCR) foi realizado no Laboratório de Líquor, Fundação José Silveira, Salvador, Brazil, entre 1988 e 2002, foram revistas. Aqueles com suspeita clínica de NE e teste de imunofluorescência indireta (IFI) e ou inibição da hemaglutinação (IHA) positivos para S. mansoni foram identificados. Resultados: dos 377 pacientes, 67,9% eram do sexo masculino, a mediana da idade foi 36 anos (média 37 + 16 anos, variação 3-82 anos). As queixas mais freqüentes foram paraparesia (59,9%), retenção urinária (36,2%), dor em membros inferiores (22,8%). A celularidade do LCR (células/mm 3 ) foi > 4 em 66,0% (média 83 + 124, mediana 40, variação 4,3 -1.100), a proteína (mg/dl) foi > 40 em 84,6% (média 185 + 519, mediana 81, variação 41-6.800) e eosinófilos estavam presentes em 46,9%. IFI e IHA foram positivas em 75,3%. Celularidade > 4 e presença de eosinófilos estiveram associadas com IFI e IHA positivas (67,3% versus 51,4%, p 0,014; 49,1% versus 23,0%, p 0,0001, respectivamente) e proteína > 40 não foi (85,4% versus 77,0%, p 0,09). Celularidade > 4, proteína > 40 e eosinófilos estiveram associados com IFI e IHA positivos (71,6% versus 38,2%, p 0,0003) mas a presença de eosinófilos e qualquer outra combinação de celularidade e proteína não estiveram. Conclusão: NE deve ser considerada uma possibilidade diagnóstica em pacientes que tiveram epidemiologia positiva para S. mansoni e desenvolveram uma mielopatia. A presença de IFI e IHA positivos para S. mansoni, celularidade > 4, proteína > 40 e presença de eosinófilos no líquor pode ser considerado critério de alta probabilidade para o diagnóstico presuntivo da NE. PALAVRAS-CHAVE: neuroesquistossomose, líquor, diagnóstico liquórico, mielite, mielorradiculite, Schistosoma mansoni.This investigation was conducted at the CSF Lab -José Silveira Foundation,

show abstract

Esquistossomose medular: Granulomas produzidos por ovos de Schistosoma Mansoni comprimindo a medula, epicone, cone e cauda eqüina

Cited by 27 publications

References 1 publication

Spinal cord schistosomiasis in children: analysis of seven cases

Spinal cord schistosomiasis in children: analysis of seven cases

Schistosomiasis of the Spinal Cord, Conus and Cauda

Clinical and cerebrospinal fluid (CSF) profile and CSF criteria for the diagnosis of spinal cord schistosomiasis

Contact Info

Product

Resources

About