Effect of hyperthermia on experimental acute pancreatitis

Abstract

-Background -Recent studies indicate that hyperthermia can change infl ammatory mechanisms and protect experimental animals from deleterious effects of secretagogue-induced acute pancreatitis. Aim -To evaluate the effects of hyperthermia posttreatment on cerulein-induced acute pancreatitis in rats. Methods -Twenty animals were divided in two groups: group I (n = 10), rats with cerulein-induced acute pancreatitis undergone hyperthermia, and group II (n = 10), animals with cerulein-induced acute pancreatitis that were kept normothermic. In all groups, amylase serum levels, histologic damage, vascular permeability and pancreatic water content were assessed. Acute pancreatitis was induced by administration of two cerulein injections (20 mcg/kg). A single dose of Evans' blue dye was administered along with the second dose of cerulein. All animals also received a subcutaneous injection of saline solution. After this process, animals undergone hyperthermia were heated in a cage with two 100 W lamps. Body temperature was increased to 39.5ºC and maintained at that level for 45 minutes. Normothermia rats were kept at room temperature in a second cage. Results -Control animals had typical edema, serum amylase activity and morphologic changes of this acute pancreatitis model. Hyperthermia post-treatment ameliorated the pancreatic edema, whereas the histologic damage and the serum amylase level remained unchanged. Conclusions -The fi ndings suggest a benefi cial effect of the thermal stress on infl ammatory edema in experimental acute pancreatitis.

Hyperthermia Induced by Near-Infrared Laser-Irradiated CsWO3 Nanoparticles Disintegrates Preformed Lysozyme Amyloid Fibrils

“…Since the early nineteenth century, when sources of electromagnetic waves were first discovered [28], medical hyperthermia has been useful in the treatment of a handful of diseases such as cancer, inflammatory disorders, Peyronie's diseases, and fibromyalgia syndrome [29][30][31]. From somatic point of view, thermal treatment allows the healing of wound and relief of pain and stress through a number of means including, but not limited to, accelerated bio-metabolism and an increase in the velocities of nerve conduction and blood flow [30].…”